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An incremental bundle method for portfolio selection problem under second-order stochastic dominance
Numerical Algorithms - We propose a preconditioner to accelerate the convergence of the GMRES iterative method for solving the system of linear equations obtained from discretize-then-optimize... 相似文献
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Nonlinear Dynamics - The active disturbance rejection control (AD RC), first proposed by Jingqing Han in late 1980s, is a powerful control technology being able to deal with external disturbances... 相似文献
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Xin-Xin Peng Hang Zhang Ruijing Zhang Ze-Hao Li Zi-Shu Yang Jing Zhang Song Gao Jun-Long Zhang 《Angewandte Chemie (International ed. in English)》2023,62(36):e202307838
The gallium ion (Ga3+) has long been believed to disrupt ferric homeostasis in the body by competing with iron cofactors in metalloproteins, ultimately leading to cell death. This study revealed that through an indirect pathway, gallium can trigger ferroptosis, a type of non-apoptotic cell death regulated by iron. This is exemplified by the gallium complex of the salen ligand ( Ga-1 ); we found that Ga-1 acts as an effective anion transporter that can affect the pH gradient and change membrane permeability, leading to mitochondrial dysfunction and the release of ferrous iron from the electron transfer chain (ETC). In addition, Ga-1 also targeted protein disulfide isomerases (PDIs) located in the endoplasmic reticulum (ER) membrane, preventing the repair of the antioxidant glutathione (GSH) system and thus enforcing ferroptosis. Finally, a combination treatment of Ga-1 and dietary polyunsaturated fatty acids (PUFAs), which enhances lipid peroxidation during ferroptosis, showed a synergistic therapeutic effect both in vitro and in vivo. This study provided us with a strategy to synergistically induce Ferroptosis in tumor cells, thereby enhancing the anti-neoplastic effect. 相似文献
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A prototype of the ME readout electronics onboard the Hard X-ray Modulate Telescope (HXMT) satellite is developed. Application Specific Integrated Chip (ASIC) is used to construct the front end electronics due to a large number of detectors. Field Programmable Gate Array (FPGA) is connected to the ASIC as a state machine controller and data FIFO in the DAQ system. A USB board is designed to communicate between the DAQ system and the computer. The design goals and features, the operation of the system and the preliminary performance of the prototype are described. The testing results show that the design goals of the prototype system have been achieved. 相似文献
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Zi-Ming Ye Xue-Wen Zhang Prof. Pei-Qin Liao Yi Xie Yan-Tong Xu Xue-Feng Zhang Chao Wang De-Xuan Liu Ning-Yu Huang Ze-Hao Qiu Dr. Dong-Dong Zhou Prof. Chun-Ting He Prof. Jie-Peng Zhang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(51):23522-23528
Porous molecular crystals sustained by hydrogen bonds and/or weaker connections are an intriguing type of adsorbents, but they rarely demonstrate efficient adsorptive separation because of poor structural robustness and tailorability. Herein, we report a porous molecular crystal based on hydrogen-bonded cyclic dinuclear AgI complex, which exhibits exceptional hydrophobicity with a water contact angle of 134°, and high chemical stability in water at pH 2–13. The seemingly rigid adsorbent shows a pore-opening or nonporous-to-porous type butane adsorption isotherm and complete exclusion of isobutane, indicating potential molecular sieving. Quantitative column breakthrough experiments show slight co-adsorption of isobutane with an experimental butane/isobutane selectivity of 23, and isobutane can be purified more efficiently than for butane. In situ powder/single-crystal X-ray diffraction and computational simulations reveal that a trivial guest-induced structural transformation plays a critical role. 相似文献
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以王磊提出的化学学科能力框架为理论依据,对“物质构成的奥秘”主题进行分析,从核心知识经验、认识角度思路、认识对象及问题、能力活动要素等4个维度构建了“物质构成的奥秘”主题的学科能力模型。运用实验法进行教学实践,证实了本研究设计的教学方式更有利于学生学科能力的发展提升。最后提出学科能力导向的“物质构成的奥秘”教学设计模式和教学实施的有效策略:(1)单元整体系统化设计,有层次有梯度的发展学生学科能力;(2)侧重应用实践型任务的解决,外显知识的输出性功能和价值;(3)重视核心知识和认识角度的建立过程;(4)追问、外显学生的认识角度和认识思路。 相似文献