Polymeric nanocarriers for cancer theranostics

Theranostics is an emerging area in nanomedicine where therapeutic and diagnostic platforms are integrated together to perform multiple functions such as disease diagnostic and therapy, noninvasive method to determine the targeted delivery of drugs, and evaluation of drug efficacy. This review gives an overview of the different therapeutic and diagnostic strategies used to construct a theranostic system. The importance of polymer‐based theranostic carriers is presented. The different types of polymeric carriers such as micelles, liposomes, dendrimers, and nanogels explored for theranostic applications are also presented. Copyright © 2017 John Wiley & Sons, Ltd.     

Comparative Analysis of the Characteristics of the Vortex Wake behind a Flapping Wing Performing Oscillations of Different Types

The wake characteristics of a custom-designed airfoil performing pitching oscillations, heaving oscillations, and a combination of pitch and heave oscillations are compared in this study. The influence of flapping parameters are investigated at a constant Reynolds number Re\(_{c} = 2640\) and is presented for the Strouhal numbers based on the oscillation amplitude, St_A, varying in the \(0.1 \leqslant {\text{S}}{{{\text{t}}}_{A}} \leqslant 0.4\) range. The generation of vorticity above and below the airfoil depends on the airfoil’s initial direction of motion and remains the same for all types of flapping oscillations investigated. The evolution of the leading-edge and trailing-edge vortices is presented. The heaving oscillations of the airfoil are found to have a greater influence on the characteristics of the leading edge vortex. The wake behind the combined pitch-heave oscillations appears to be governed by pitching oscillations below \({\text{S}}{{{\text{t}}}_{A}} = 0.24\), whereas it is driven by heaving oscillations above \({\text{S}}{{{\text{t}}}_{A}} = 0.24\). The force computations indicate that the mere existence of the reverse von Kármán street is not sufficient to develop the thrust on the airfoil. The periodic component of velocity fluctuations significantly influences the wake characteristics. The anisotropic stress field developed around the airfoil due to the periodic fluctuations of the velocity is presented. The coherent structures developed in the wake are identified using the proper orthogonal decomposition and a qualitative comparison of the structures for different flapping oscillations is presented. The energy transfer from the flapping airfoil to the fluid for different flapping oscillations is highest for heaving oscillations followed by combined pitch-heave oscillations and pitching oscillations.

     

Thermal properties of tannin extracted from Anacardium occidentale L. using TGA and FT-IR spectroscopy

The chemical nature of the polyphenols of cashew kernel testa has been determined. Testa contains tannins, which present large molecular complexity and has an ancient use as tanning agents. The use of tannins extracted from cashew testa, considered in many places as a waste, grants an extra value to the cashew. In this work we have analysed through high performance liquid chromatography, infrared spectroscopy (FT-IR) and thermo gravimetric analysis the average molecular weight, main functional groups and thermal properties of tannins extracted from Anacardium occidentale L. The results of these analyses are compared with the commercial grade tannic acid. The FT-IR spectra showed bands characteristic of C = C, C–C and OH bonds. This important bioactive compound present in the cashew nut kernel testa was suggested as an interesting economical source of antioxidants for use in the food and nutraceutical industry.     

A reduced-order deterministic model describing an intermittency route to combustion instability

Recently, there has been a growing interest in understanding and characterising intermittent burst oscillations that presage the onset of combustion instability. We construct a deterministic model to capture this intermittency route to instability in a bluff-body stabilised combustor by coupling the equations governing vortex shedding and the acoustic wave propagation in a confinement. A feedback mechanism is developed wherein the sound generated due to unsteady combustion affects the vortex shedding. This feedback leads to a variation in the time of impingement of the vortices with the bluff body causing the system to exhibit chaos, intermittency, and limit cycle oscillations. Experimental validation of the model is provided using various precursor measures that quantify the observed intermittent states.     

Comparison and correlation of in vitro, in vivo and in silico evaluations of alpha, beta and gamma cyclodextrin complexes of curcumin

In the present study investigated the effect of curcumin (CUR) alpha (α), beta (β) and gamma (γ) cyclodextrin (CD) complexes on its solubility and bioavailability. CUR the active principle of turmeric is a natural antioxidant agent with potent anti-inflammatory activity along with chemotherapeutic and chemopreventive properties. Poor solubility and poor oral bioavailability are the main reasons which preclude CUR use in therapy. Extent of complexation was β-CD complex (82 %) > γ-CD (71 %) > α-CD (65 %). Pulverization method resulted in significant enhancement of CUR (0.002 mg/ml) solubility with CUR α-CD complex (0.364 mg/ml) > CUR β-CD complex (0.186 mg/ml) > CUR γ-CD complex (0.068 mg/ml). Gibbs-free energy and in silico molecular docking studies favour formation of α-CD complex > β-CD complex > γ-CD complex. With reference to CUR, relative bioavailability of CUR α-CD, CUR β-CD and CUR γ-CD complexes were 460, 365 and 99 % respectively. CUR–CD complexes exhibited increased bioavailability with an increase in t_½, tmax, Cmax, AUC, Ka, and MRT; and a decrease in Ke, clearance and Vd values. AUC increase was CUR α-CD complex > CUR β-CD complex > CUR γ-CD complex. Significant difference (p < 0.05) was observed between CUR α-CD complex and CUR γ-CD complex by one-way ANOVA and Dunnett’s post hoc test for multiple comparison analysis. Correlation observed between in vitro, in vivo and in silico methods indicates potential of in silico and in vitro methods in CD selection.