The Geometric Construction of WZW Effective Action in Noncommutative Manifold

By constructing close-one-cochain density Ω^12n in the gauge group space we get the Wess-Zumino-Witten (WZW) effective Lagrangian on high-dimensional noncommutative space.Especially consistent anomalies derived from this WZW effective action in noncommutative four-dimensional space coincide with those obtained by L.Bonora etc.(het-th/0002210).     

Microfluidic adhesion analysis of single glioma cells for evaluating the effect of drugs

Cancer metastasis is one of the most serious problems for tumor therapy, which is closely related to cell adhesion and deadhesion process. Better comprehension of cell adhesion ability will benefit drug research. Here, a biomimetic microfluidic enzyme digestion method was proposed to gently measure the influence of drugs on cell-matrix adhesion ability at the single cell level.The method can selectively digest the extracellular matrix(ECM) that linked to a single cell, and the trypsin concentration around the cell is relatively uniform and constant, thus the measured cell adhesion strength should be precise. Commercially available anti-cancer agents including 5-fluorouracil(5-FU), actinomycin D(Act D), temozolomide(TMZ) and allicin were evaluated, and the data showed only TMZ and allicin can inhibit cell adhesion significantly under our experiment conditions. The influence of TMZ became more and more obvious as the increase of duration and the effect became prominent only after 6 h adhesion process, which could provide a quick evaluation of whether the drugs are effective to cancer cell(compared with Calcein-AM/PI cell viability test). The adhesion strength of U87 cells decreased when the concentration of TMZ increased, and the effect of TMZ can be effectively inhibited by adding lactic acid to culture medium, which indicated acidic tumor microenvironment could promote drug resistance of tumor cells. Different from conventional evaluation methods which focus on the drugs' influence on cellular viability or metabolism, this work provides a new perspective to study the effect of drugs, which is helpful to enrich the drug evaluation system.     

活性炭纤维对氙的动态吸附性能研究

采用动态吸附实验装置，研究了吸附温度、原料气浓度和原料气流量对活性炭纤维动态吸附氙性能的影响。结果表明：在低温条件下（≤273K)，随着温度的升高，活性炭纤维对氙的平衡吸附量明显下降／同时，活性炭纤维对氙的平衡吸附量分别随着原料气浓度及原料气流量的增大而增大。     

衍生化β-环糊精手性固定相高效液相色谱法拆分米那普仑对映体及其分离机制

建立了新型抗抑郁药米那普仑在环糊精手性固定相上的高效液相色谱拆分方法。在反相色谱条件下采用未衍生化β-环糊精(Cyclobond I 2000)、乙酰基-β-环糊精(AC-β-CD)、2,3-二甲基-β-环糊精(DM-β-CD)、3,5-二甲基苯基氨基甲酸酯-β-环糊精(DMP-β-CD)4种手性柱分离米那普仑对映体。考察了固定相、流动相比例、pH、流速和柱温对拆分的影响。利用分子对接和结合能计算方法,研究米那普仑分子与AC-β-CD的对接过程,探讨其可能的分离机制。优化后的拆分条件如下:固定相为乙酰基-β-环糊精手性柱Astec CYCLOBONDTMI 2000 AC(25 cm×4.6 mm,5μm),流动相为乙腈-0.1%(体积分数)pH 5.0醋酸三乙胺溶液(TEAA)(5∶95,v/v),流速为0.4mL/min,柱温为25℃,检测波长为220 nm。在此条件下,米那普仑对映体获得快速拆分,分离度(Rs)为1.74,理论塔板数为10 125。分子模拟结果表明引起手性识别的作用力主要是环糊精衍生化的乙酰基导致的氢键作用差异。该方法快速、高效、重现性好。     

电磁感应透明的高阶非线性效应对光孤子的影响

研究了电磁感应透明介质中高阶非线性效应对光孤子传输的影响。采用半经典理论获得介质对光场的线性和非线性响应,基于介质特性利用波动理论推演出三-五阶非线性薛定谔方程。介质的线性非线性特性分别决定了群速度色散参量,三阶和五阶非线性系数。研究结果表明,该非线性介质既可以诱导亮孤子也可以诱导暗孤子,取决于群速度色散参量和三阶非线性系数。当前者为负同时后者为正时产生亮孤子,当两者均为负时产生暗孤子,二者可以通过载频与相应跃迁能级失谐的调节获得。与普通非线性薛定谔方程相比,三-五阶非线性薛定谔方程对亮孤子和暗孤子出现的参数和输入条件更加严格。     

A periodic DFT study on adsorption of small molecules(CH4,CO,H2O,H2S,NH3)on the WO3(001) surface-supported Au

Gas molecules(such as CH4,CO,H2O,H2S,NH_3)adsorption on the pure and Au-doped WO3(001)surface have been studied by Density functional theory calculations with generalized gradient approximation.Based on the the calculation of adsorption energy,we found the most stable adsorption site for gas molecules by comparing the adsorption energies of different gas molecules on the WO3(001)surface.We have also compared the adsorption energy of five different gas molecules on the WO3(001)surface,our calculation results show that when the five kinds of gases are adsorbed on the pure WO3(001)surface,the order of the surface adsorption energy is CO>H2S>CH4>H2O>NH3.And the results show that NH3 is the most easily adsorbed gas among the other four gases adsorbed on the surface of pure WO3(001)surface.We also calculated the five different gases on the Au-doped WO3(001)surface.The order of adsorption energy was found to be different from the previous calculation:CO>CH4>H2S>H2O>NH3.These results provide a new route for the potential applications of Au-doped WO3 in gas molecules adsorption.     

A study on the chiral recognition mechanism of enantioseparation of adrenaline and its analogues using capillary electrophoresis

The purpose of this paper was to study the chiral recognition mechanism of enantioseparation of adrenaline and its analogues using capillary electrophoresis. The enantiomeric separation of adrenaline and its analogues has been developed using beta-cyclodextrins as the chiral selectors. All the tested compounds were separated under the same experimental conditions to study the chiral recognition mechanisms, using a low-pH buffer (50 mM Tris buffer at pH 2.5). By means of molecular docking the inclusion course between beta-cyclodextrins and enantiomers was investigated and thus the interaction energy was obtained by molecular mechanics calculations. The results suggest that the difference in interaction energy for the side chain part is most likely responsible for enantiomeric separation.     

镜象电流选择的唯一性

利用稳恒磁场边值问题解答的唯一性定量和维尔斯特拉斯定理讨论了镜象电流选择的唯一性。     

头发中单乙酰吗啡和吗啡检测的研究

建立了用ＧＣ－ＭＳ技术检测人头发中毒品海洛因的主要代谢产物６－单乙酰吗啡和吗啡的方法。以乙基吗啡为内标，样品酸水解后用混合有机溶剂提取。提取物经Ｎ－甲基－Ｎ－三甲基硅基三氟乙酰胺（ＭＳＴＦＡ）衍生化，采用ＧＣ－ＭＳ定性定量分析。该法已用于确认经常性滥用海洛因的实际检案分析