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排序方式: 共有249条查询结果,搜索用时 15 毫秒
1.
Rathore Vikas Tiwari Budhi Sagar Nema Sudhir Kumar 《Plasma Chemistry and Plasma Processing》2022,42(1):109-129
Plasma Chemistry and Plasma Processing - The present study has been carried to investigate the interaction and effect of plasma activated water (PAW) on pea seeds. PAW is produced with the... 相似文献
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Robert D. Bongard Michael Lepley Khushabu Thakur Marat R. Talipov Jaladhi Nayak Rachel A. Jones Lipinski Chris Bohl Noreena Sweeney Ramani Ramchandran Rajendra Rathore Daniel S. Sem 《BMC biochemistry》2017,18(1):10
Background
Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficult targets for designing inihibitors that become viable drug leads. Therefore, the pipeline for approved drugs in this class is minimal. Furthermore, drug screening for targets like PTPs often produce false positive and false negative results.Results
Studies presented herein provide important insights into: (a) how to detect such artifacts, (b) the importance of compound re-synthesis and verification, and (c) how in situ chemical reactivity of compounds, when diagnosed and characterized, can actually lead to serendipitous discovery of valuable new lead molecules. Initial docking of compounds from the National Cancer Institute (NCI), followed by experimental testing in enzyme inhibition assays, identified an inhibitor of DUSP5. Subsequent control experiments revealed that this compound demonstrated time-dependent inhibition, and also a time-dependent change in color of the inhibitor that correlated with potency of inhibition. In addition, the compound activity varied depending on vendor source. We hypothesized, and then confirmed by synthesis of the compound, that the actual inhibitor of DUSP5 was a dimeric form of the original inhibitor compound, formed upon exposure to light and oxygen. This compound has an IC50 of 36 μM for DUSP5, and is a competitive inhibitor. Testing against PTP1B, for selectivity, demonstrated the dimeric compound was actually a more potent inhibitor of PTP1B, with an IC50 of 2.1 μM. The compound, an azo-bridged dimer of sulfonated naphthol rings, resembles previously reported PTP inhibitors, but with 18-fold selectivity for PTP1B versus DUSP5.Conclusion
We report the identification of a potent PTP1B inhibitor that was initially identified in a screen for DUSP5, implying common mechanism of inhibitory action for these scaffolds.3.
Anshu Dandia Dinesh Kumar Mahawar Ruchi Sharma Ranveer Singh Badgoti Kuldeep S. Rathore Vijay Parewa 《应用有机金属化学》2019,33(11)
Graphene oxide (GO)‐catalyzed selective synthesis of amides via CSp3–H activation of methylarenes and consequent C–N bond formation with anilines under aqueous medium has been described. Oxygen functionality allied with GO surface played a dual role both as acid catalyst and oxidizing agent to some extent. However, GO has a copious effect on the reaction, shown by a high TOF value with TBHP as co‐oxidant. The decisive role of carboxylic acid functional groups on GO nanosheets in this metal‐free strategy has been confirmed and was monitored by various analytic techniques viz. Fourier transform‐infrared, UV–Vis, Raman and XPS. A plausible mechanism was proposed by control experiments and by the isolation of the intermediate. Over‐oxidation of methylarenes was not detected, and high recyclability of the carbocatalyst with its heterogeneous behavior facilitated the isolation and purification of the desired products. We have further explored the utility of this process for the chemoselective synthesis of benzimidazoles. 相似文献
4.
E. Makrlík P. Toman P. Vaňura R. Rathore 《Journal of Radioanalytical and Nuclear Chemistry》2013,296(2):775-779
In methods for quantification of 63Ni, in e.g. reactor coolant water, a chemical separation is required due to 63Ni being a pure beta emitter with limited means of quantification. 60Co, a common radionuclide in reactor coolant water, is not completely separated with the commonly used separation procedure, and it is not resolved from 63Ni in the beta spectrum. The separation method discussed in this work consists of TRU resin (Eichrom) and Ni resin (Eichrom). After running the separation procedure, depending on the initial activity of 60Co, there may still remain enough 60Co to interfere in the measurement of 63Ni. The 60Co interference is corrected for via a gamma spectrometric measurement. This correction may, depending on the 63Ni/60Co ratio, introduce a large contribution to the measurement uncertainty. The aim of this work was to evaluate the possibility to reduce the measurement uncertainty of 63Ni measurements by adding a second Ni separation to the method. Double Ni separations were performed on reactor coolant water having a 60Co activity much higher than the 63Ni activity (63Ni/60Co = 0.01), in order to decrease the radioactivity of 60Co in the sample. The measurement uncertainty of the 63Ni measurement result was reduced by a factor of about three. 相似文献
5.
Oxidation of indans and tetralin derivatives to their corresponding indanones and tetralones is of considerable value i n organic synthesis and many methods have been reported for accomplishing this conversion. Traditionally these oxidations are performed with chromic acid in acetic acid and the yields in general are moderate. Recently Eisenbraun4 has studied indetail the benzylic oxidation with the Jones reagent and compared the selectivity and yield of oxidation with other chromium(V1) reagents like bipyridinim chlorochrmate, (BiPCC). It was found that there was no improvement in yield and in the case of BiPCC a molar ratio 16% 1 (oxidant: substrate) was employed to get 相似文献
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8.
Grignard condensation routes to 1,3‐disilacyclobutane‐containing cyclolinear polycarbosilanes 下载免费PDF全文
Xinxing Liu Jitendra S. Rathore Geraud Dubois Leonard V. Interrante 《Journal of polymer science. Part A, Polymer chemistry》2017,55(9):1547-1557
Alkylene‐ and arylene‐bridged cyclolinear polycarbosilanes (CLPCS) with 1,3‐disilacyclobutane (DSCB) rings incorporated in the main chain of the polymer were prepared by polycondensation between corresponding di‐functional DSCB derivatives and di‐Grignard reagents. Well‐defined, low molecular weight (Mn = 3–5K; DP = 17–26), hexylene‐ and phenylene‐bridged CLPCS polymers were obtained without appreciable ring opening of the DSCB rings. Large exothermic peaks were observed in the DSC for these CLPCSs, which indicated, along with the IR spectra, that crosslinking occurred on heating to about 250 °C via the ring opening of the embedded, alternating, DSCB rings. Moreover, PB‐CLPCS undergoes photochemically induced crosslinking on UV irradiation to form crosslinked polycarbosilane network films. The spin‐cast, cured, films of these CLPCSs exhibit relatively low dielectric constants and promising thermal and mechanical properties for applications in electronics, for example, directly UV‐photoimprinted low‐k dielectrics. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 1547–1557 相似文献
9.
Anshu Dandia Shyam L. Gupta Aayushi Indora Pratibha Saini Vijay Parewa Kuldeep S. Rathore 《Tetrahedron letters》2017,58(12):1170-1175
We have synthesized and characterized Ag NPs decked GO composite and studied its role as reusable catalyst for the ‘ON WATER’ chemoselective synthesis of pyranodipyrazolones via the reaction of different carbonyl compounds with 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. This method illustrates significant selectivity for pyranodipyrazolones over arylmethylene bispyrazolols and arylmethylenepyrazolones. Synergistic effect of heterogenic nature of water with reactants and Ag NPs/GO had profuse outcome on reaction as indicated by high TOF (18.03 × 10?5 mol g?1 min?1). Furthermore, catalyst was recycled for 7-times without significant loss of activity. 相似文献
10.
In this paper dynamic routing and wavelength assignment strategies have been proposed for multiclass WDM optical networks. Multiclass optical networks provide multiple classes of services to the subscriber according to the requirement, which in turn increase operational profitability. Each class of service could be characterized by parameters like number of wavelengths, expected call holding time and average arrival rate of request. The proposed strategies have been analyzed and compared with existing strategies on the basis of blocking probabilities for multiclass traffic scenarios. Simulation results on different network topologies demonstrate that the performance of proposed strategies “Fixed shortest/alternate shortest path routing with wavelength reservation (FSASWR)” and “Fixed alternate shortest path routing with least priority wavelength assignment (FASPL)” are much better as compared to existing strategies. Proposed strategies minimize blocking probability of the multiclass network using limited number of wavelengths. 相似文献