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1.
In this study, Fe3O4@TiO2 nanoparticles were synthesized as a new Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) hybrid imaging agent and radiolabeled with 89Zr. In addition, Fe3O4 nanoparticles were synthesized and radiolabeled with 89Zr. Df-Bz-NCS was used as bifunctional ligand. The nanoconjugates were characterized with transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. Radiolabeling yields were 100%. Breast and prostate cancer cell affinities and cytotoxicity were determined using in vitro cell culture assays. The results demonstrated that Fe3O4@TiO2 nanoparticles are promising for PET/MR imaging. Finally, unlike Fe3O4 nanoparticles, Fe3O4@TiO2 nanoparticles showed a fluorescence spectrum at an excitation wavelength of 250 nm and an emission wavelength of 314 nm. Therefore, in addition to bearing the magnetic properties of Fe3O4 nanoparticles, Fe3O4@TiO2 nanoparticles display fluorescence emission. This provides them with photodynamic therapy potential. Therefore multimodal treatment was performed with the combination of PDT and RT by using human prostate cancer cell line (PC3). The development of 89Zr-Df-Bz-NCS-Fe3O4@TiO2 nanoparticles as a new multifunctional PET/MRI agent with photodynamic therapy and hyperthermia therapeutic ability would be very useful. 相似文献
2.
Sinan Bayindir Esra Erdogan Haydar Kilic Omer Aydin Nurullah Saracoglu 《Journal of heterocyclic chemistry》2015,52(5):1589-1594
A survey of redox aminations of indoline with aliphatic ketones using bismuth nitrate as catalyst is described. A reaction of an equivalent amount of indoline and aliphatic cyclic and acyclic ketones provides a mixture of excessive alkylated indole derivatives over typically redox isomerization and reductive alkylation pathways while using of the five equivalent of indoline provides N‐alkylated indolines as a reductive alkylation product. The desired N‐alkyl indoles from the oxidation of N‐alkyl indolines were obtained in excellent yields. 相似文献
3.
Redox Amination Scope of Benzylic Ketones with Indoline: Synthetic and Mechanistic Insights 下载免费PDF全文
Omer Aydin Haydar Kilic Sinan Bayindir Esra Erdogan Nurullah Saracoglu 《Journal of heterocyclic chemistry》2015,52(5):1540-1553
Bi(NO3)3·5H2O‐Catalyzed redox amination scope and mechanistic insights of benzylic ketones with indoline are discussed. The experimental results demonstrate that the formation of N‐alkyl‐substituted indole/indoline derivatives over typically competitive redox and reductive amination processes is depending upon the reaction condition for the benzylic ketones. 相似文献
4.
We compute the homology of random ?ech complexes over a homogeneous Poisson process on the d‐dimensional torus, and show that there are, coarsely, two phase transitions. The first transition is analogous to the Erd?s ‐Rényi phase transition, where the ?ech complex becomes connected. The second transition is where all the other homology groups are computed correctly (almost simultaneously). Our calculations also suggest a finer measurement of scales, where there is a further refinement to this picture and separation between different homology groups. © 2016 Wiley Periodicals, Inc. Random Struct. Alg., 51, 14–51, 2017 相似文献
5.
Omer Anis Ajjampura C. Vinayaka Nurit Shalev Dvora Namdar Stalin Nadarajan Seegehalli M. Anil Ofer Cohen Eduard Belausov Jacob Ramon Einav Mayzlish Gati Hinanit Koltai 《Molecules (Basel, Switzerland)》2021,26(2)
Cannabis sativa contains more than 500 constituents, yet the anticancer properties of the vast majority of cannabis compounds remains unknown. We aimed to identify cannabis compounds and their combinations presenting cytotoxicity against bladder urothelial carcinoma (UC), the most common urinary system cancer. An XTT assay was used to determine cytotoxic activity of C. sativa extracts on T24 and HBT-9 cell lines. Extract chemical content was identified by high-performance liquid chromatography (HPLC). Fluorescence-activated cell sorting (FACS) was used to determine apoptosis and cell cycle, using stained F-actin and nuclei. Scratch and transwell assays were used to determine cell migration and invasion, respectively. Gene expression was determined by quantitative Polymerase chain reaction (PCR). The most active decarboxylated extract fraction (F7) of high-cannabidiol (CBD) C. sativa was found to contain cannabichromene (CBC) and Δ9-tetrahydrocannabinol (THC). Synergistic interaction was demonstrated between CBC + THC whereas cannabinoid receptor (CB) type 1 and type 2 inverse agonists reduced cytotoxic activity. Treatments with CBC + THC or CBD led to cell cycle arrest and cell apoptosis. CBC + THC or CBD treatments inhibited cell migration and affected F-actin integrity. Identification of active plant ingredients (API) from cannabis that induce apoptosis and affect cell migration in UC cell lines forms a basis for pre-clinical trials for UC treatment. 相似文献
6.
Omer Lustgarten Raanan Carmieli Leila Motiei David Margulies 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(1):190-194
A method for implementing a secret sharing scheme at the molecular level is presented. By creating molecular code generators that are self‐assembled from several molecular components, we established a means for distributing distinct code‐activating elements among several participants. In this way, an authorization code can only be generated when all the participants are present, which ensures that highly secured systems cannot be operated by unauthorized individuals or disloyal users. Additional layers of protection result from the ability to program the security code by replacing one or several molecular components and by subjecting the system to distinct chemical inputs. 相似文献
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New tandospirone analogues containing a 1-[3-(trifluoromethyl)phenyl]piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)2. The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported. 相似文献
10.
Afzal Hafiz Muhammad Shehzad Farrukh Zubair Mukarram Bakather Omer Yahya Al-Harthi Mamdouh A. 《Journal of Thermal Analysis and Calorimetry》2020,139(1):353-365
Journal of Thermal Analysis and Calorimetry - This article discusses the effect of microwave irradiation on the thermal properties of poly(vinyl alcohol)/graphene nanocomposites, prepared using a... 相似文献