Synthesis of N‐Alkylated Indolines and Indoles from Indoline and Aliphatic Ketones |
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| Authors: | Sinan Bayindir Esra Erdogan Haydar Kilic Omer Aydin Nurullah Saracoglu |
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| Affiliation: | 1. Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey;2. Department of Chemistry, Faculty of Sciences and Arts, Bing?l University, Bing?l, Turkey |
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| Abstract: | A survey of redox aminations of indoline with aliphatic ketones using bismuth nitrate as catalyst is described. A reaction of an equivalent amount of indoline and aliphatic cyclic and acyclic ketones provides a mixture of excessive alkylated indole derivatives over typically redox isomerization and reductive alkylation pathways while using of the five equivalent of indoline provides N‐alkylated indolines as a reductive alkylation product. The desired N‐alkyl indoles from the oxidation of N‐alkyl indolines were obtained in excellent yields. |
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