排序方式: 共有43条查询结果,搜索用时 15 毫秒
1.
Sinan Bayindir Esra Erdogan Haydar Kilic Omer Aydin Nurullah Saracoglu 《Journal of heterocyclic chemistry》2015,52(5):1589-1594
A survey of redox aminations of indoline with aliphatic ketones using bismuth nitrate as catalyst is described. A reaction of an equivalent amount of indoline and aliphatic cyclic and acyclic ketones provides a mixture of excessive alkylated indole derivatives over typically redox isomerization and reductive alkylation pathways while using of the five equivalent of indoline provides N‐alkylated indolines as a reductive alkylation product. The desired N‐alkyl indoles from the oxidation of N‐alkyl indolines were obtained in excellent yields. 相似文献
2.
Redox Amination Scope of Benzylic Ketones with Indoline: Synthetic and Mechanistic Insights 下载免费PDF全文
Omer Aydin Haydar Kilic Sinan Bayindir Esra Erdogan Nurullah Saracoglu 《Journal of heterocyclic chemistry》2015,52(5):1540-1553
Bi(NO3)3·5H2O‐Catalyzed redox amination scope and mechanistic insights of benzylic ketones with indoline are discussed. The experimental results demonstrate that the formation of N‐alkyl‐substituted indole/indoline derivatives over typically competitive redox and reductive amination processes is depending upon the reaction condition for the benzylic ketones. 相似文献
3.
Cemil Aydoğan Hakiye Aslan Zeynep Günyel Nurullah Demir İbrahim Y. Erdoğan Sarah Alharthi Ziad El Rassi 《Electrophoresis》2021,42(24):2637-2646
In this study, graphene oxide-octadecylsilane incorporated monolithic nano-columns were developed for protein analysis by nano liquid chromatography (nano LC). The monolithic column with 100 μm id was first prepared by an in situ polymerization using ethylene dimethacrylate (EDMA), 3-chloro-2-hydroxypropylmethacrylate (HPMA-Cl), and methacryloyl graphene oxide nanoparticles (MGONPs). MGONPs were synthesized by the treatment of 3-(trimethoxysilyl)propylmethacrylate (TMSPM) and GO. Tetrahydrofuran (THF) and dodecanol were used as the porogenic solvent. The resulting column was functionalized by dimethyloctadecylch lorosilane (DODCS) for the enhancement of hydrophobicity. The functionalization greatly improved the baseline separation of hydrophobic compounds such as polyaromatic hydrocarbons (PAHs). The optimized monolith with respect to total polymerization mixture was characterized by using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) X-ray diffraction (XRD) and chromatographic analyses. The blank monoliths without functionalization exhibited poor separation while a good separation performance of MGONPs functionalized monoliths was achieved. The monolith with 100 μm id was evaluated in protein separation in nano LC using RNase A, Cytochrome C, Lysozyme, Trypsin, and Ca isozyme II as the test proteins. It was shown that protein separation mechanism was based on large π-system of GO and hydrophobicity of the monolithic structure. Theoretical plates number up to 57 600 plates were achieved. The nano-column with 50 μm id was also prepared using the same polymerization mixture under the same chemical conditions. These nano-columns were employed for protein separation by nano LC, and the dependence of both nano-column performance on the internal diameter was also discussed. 相似文献
4.
5.
Yunus Taskesenligil Ferruh Lafzi Haydar Kilic Nurullah Saracoglu 《Journal of heterocyclic chemistry》2019,56(12):3289-3296
Pd(II)‐catalyzed C‐H arylations of 5‐aminoindole using iodobenzenes as aryl source was studied. Despite pivalamide directing group at 5‐position of the indole, the direct C2‐arylation of the indole observed in high yields and with high regioselectivity. 相似文献
6.
Haydar Kilic Omer Aydin Sinan Bayindir Nurullah Saracoglu 《Journal of heterocyclic chemistry》2016,53(6):2096-2101
Bismuth nitrate catalyzed condensation reactions of indoline with 1,2‐ and 1,3‐diketones were investigated and were reported to proceed via different reaction pathways with the involvement of one or two of the carbonyl groups. While the reaction of indoline with cyclohexane‐1,3‐dione ( 4 ) gave solely condensation product, the reaction between the acetylacetone ( 5 ) and indoline provided N‐acetyl indoline as single products on retro‐aldol process. In contrast to 1,3‐diketones, the reaction with benzil ( 17 ) was performed under difficult conditions and proceeded to give secondary products. 相似文献
7.
Saracoglu N Talaz O Azizoglu A Watson WH Balci M 《The Journal of organic chemistry》2005,70(14):5403-5408
[reaction: see text] endo- and exo-2,3,4,7-tetrahydro-1H-1,4-methanobenzocycloheptene-7-carboxylic acid ethyl esters have been synthesized, and their Diels-Alder cycloaddition reactions with maleic anhydride, dimethyl acetylenedicarboxylate and singlet oxygen have been investigated. The X-ray analysis of four adducts indicated the pyramidalization of the central double bond. Density functional theory calculations on the isolated products and model compounds showed excellent agreement between the experimental and theoretical determined butterfly angles. Furthermore, it has been shown that a cyclopropyl group fused to [2.2.2] system decreases significantly the degree of the pyramidalization which is attributed to the steric interactions between the cyclopropyl group and ethano bridge of the norbornene systems. Due to the instability of the bicyclic endoperoxides, their X-ray analysis could not be carried out. DFT calculations on model compounds showed increased bending in the case of the product obtained by the addition of singlet oxygen to endo-2,3,4,7-tetrahydro-1H-1,4-methanobenzocycloheptene-7-carboxylic acid ethyl ester. 相似文献
8.
Saracoglu S Soylak M Peker DS Elci L dos Santos WN Lemos VA Ferreira SL 《Analytica chimica acta》2006,575(1):133-137
The present paper proposes a pre-concentration procedure for determination of lead and iron in several samples by flame atomic absorption spectrometry. In it, lead(II) and iron(III) ions are coprecipitated using the violuric acid-copper(II) system as collector. Afterwards, the precipitate is dissolved with 1 M HNO3 solution and the metal ions are determined. The optimization step was performed using factorial design involving the variables: pH, violuric acid mass (VA) and copper concentration (Cu).Using the optimized experimental conditions, the proposed procedure allows the determination these metals with detection limits of 0.18 μg L−1 for iron and 0.16 μg L−1 for lead. The effects of foreign ions on the pre-concentration procedure were also evaluated and the results demonstrated that this method could be applied for determination of iron and lead in several real samples. The proposed method was successfully applied to the analysis of seawater, urine, mineral water, soil and physiological solution samples. The concentrations of lead and iron achieved in these samples agree well with others data reported in the literature. 相似文献
9.
Reaction of 4,7-dihydroindole and dimethyl acetylenedicarboxylate provided a convenient route to functionalized 2-vinylindoles. Diels-Alder reactions of the 2-vinylindoles with naphthoquinone, p-benzoquinone, 1,2-dicyano-4,5-dichloroquinone, N-phenyltriazolinedione, and tetracyanoethylene were investigated to give [c]annelated 1,2-dihydro, 1,2,3,4-tetrahydro, and fully aromatized carbazoles. The structure and formation mechanism of both 2-vinylindoles and their cycloadduct are discussed. 相似文献
10.
Synthesis of Some Novel Norbornene‐Fused Pyridazines as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase 下载免费PDF全文
Ramazan Kocak Esra Turan Akın Pınar Kalın Oktay Talaz Nurullah Saracoglu Arif Dastan Ilhami Gülcin Serdar Durdagi 《Journal of heterocyclic chemistry》2016,53(6):2049-2056
The reaction of benzocyclic norbornene derivatives with tetrazines provided the 1,3‐dihydropyridazine derivatives as a single product. The dihydropyridazine derivatives have been dehydrogenated with phenyliodine bis(trifluoroacetate) to yield the corresponding pyridazines in a high yield. Two stable diazines, primary product of corresponding 1,4‐dihydropyridazine, were also isolated. Structures were then determined by 1H‐NMR, and 13C‐NMR beside to elemental analyses. The novel pyridazine derivatives ( 8 , 9 ) efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I and II (hCA I and II). In addition, these novel pyridazine derivatives ( 8 , 9 ) were evaluated for their in vitro acetylcholinesterase inhibitory activity. Ligand–receptor interactions are tested using molecular docking simulations. Obtained docking scores are in good agreement with in vitro results. 相似文献