全文获取类型
收费全文 | 357篇 |
免费 | 15篇 |
国内免费 | 3篇 |
专业分类
化学 | 275篇 |
晶体学 | 3篇 |
力学 | 7篇 |
数学 | 26篇 |
物理学 | 64篇 |
出版年
2023年 | 2篇 |
2021年 | 2篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 8篇 |
2017年 | 4篇 |
2016年 | 9篇 |
2015年 | 8篇 |
2014年 | 14篇 |
2013年 | 18篇 |
2012年 | 16篇 |
2011年 | 30篇 |
2010年 | 11篇 |
2009年 | 19篇 |
2008年 | 16篇 |
2007年 | 31篇 |
2006年 | 16篇 |
2005年 | 28篇 |
2004年 | 20篇 |
2003年 | 15篇 |
2002年 | 7篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1959年 | 1篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有375条查询结果,搜索用时 46 毫秒
1.
Katsuya Hyodo Yoshinori Arisaka Satoshi Yamaguchi Tetsuya Yoda Nobuhiko Yui 《Macromolecular bioscience》2019,19(4)
Modulation of material properties and growth factor application are critical in constructing suitable cell culture environments to induce desired cellular functions. Sulfonated polyrotaxane (PRX) surfaces with immobilized vascular endothelial growth factors (VEGFs) are prepared to improve network formation in vascular endothelial cells. Sulfonated PRXs, whereby sulfonated α‐cyclodextrins (α‐CDs) are threaded onto a linear poly(ethylene glycol) chain capped with bulky groups at both terminals, are coated onto surfaces. The molecular mobility of sulfonated PRX surfaces is modulated by tuning the number of threading α‐CDs. VEGF is immobilized onto surfaces with varying mobility. Low mobility and VEGF‐immobilization reinforce cell proliferation, yes‐associated protein activity, and rhoA, pdgf, ang‐1, and pecam‐1 gene expression. Highly mobile surfaces and soluble VEGF weakly affect these cell responses. Network formation is strongly stimulated in vascular endothelial cells only on low‐mobility VEGF‐immobilized surfaces, suggesting that molecular mobility and VEGF immobilization synergistically control cell function. 相似文献
2.
Transition Metal Chemistry - The crystal structures and magnetic properties of three coordination compounds constructed from various nitroxide radicals L and MII(hfac)2(H2O)2 building blocks... 相似文献
3.
Hiromasa Nishikiori Rudi Agus Setiawan Kyohei Miyashita Katsuya Teshima Tsuneo Fujii 《Photochemistry and photobiology》2014,90(4):747-759
Fluorescein‐dispersing titania gel films were prepared by the acid‐catalyzed sol–gel reaction using a titanium alkoxide solution containing fluorescein. The molecular forms of fluorescein in the films, depending on its acid–base equilibria, and the complex formation and photoinduced electron transfer process between the dye and titania surface were investigated by fluorescence and photoelectric measurements. The titanium species were coordinated to the carboxylate and phenolate‐like groups of the fluorescein species. The quantum efficiencies of the fluorescence quenching and photoelectric conversion were higher upon excitation of the dianion species interacting with the titania, i.e. the dye–titania complex. This result indicated that the dianion form was the most favorable for formation of the dye–titania complex exhibiting the highest electron transfer efficiency. Using nitric acid as the catalyst, the titania surface bonded to the fluorescein instead of the adsorbed nitrate ion during the steam treatment. The dye–titania complex formation played an important role in the electron injection from the dye to the titania conduction band. 相似文献
4.
Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem 下载免费PDF全文
Dr. Chengwei Liu Koichi Tagami Dr. Atsushi Minami Tomoyuki Matsumoto Jens Christian Frisvad Hideyuki Suzuki Jun Ishikawa Katsuya Gomi Prof. Dr. Hideaki Oikawa 《Angewandte Chemie (International ed. in English)》2015,54(19):5748-5752
Penitrem A is one of the most elaborated members of the fungal indole diterpenes. Two separate penitrem gene clusters were identified using genomic and RNA sequencing data, and 13 out of 17 transformations in the penitrem biosynthesis were elucidated by heterologous reconstitution of the relevant genes. These reactions involve 1) a prenylation‐initiated cationic cyclization to install the bicyclo[3.2.0]heptane skeleton (PtmE), 2) a two‐step P450‐catalyzed oxidative processes forming the unique tricyclic penitrem skeleton (PtmK and PtmU), and 3) five sequential oxidative transformations (PtmKULNJ). Importantly, without conventional gene disruption, reconstitution of the biosynthetic machinery provided sufficient data to determine the pathway. It was thus demonstrated that the Aspergillus oryzae reconstitution system is a powerful method for studying the biosynthesis of complex natural products. 相似文献
5.
Cover Picture: Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem (Angew. Chem. Int. Ed. 19/2015) 下载免费PDF全文
6.
Yoshikazu Giga Katsuya Inui Alex Mahalov Shin’ya Matsui Jürgen Saal 《Archive for Rational Mechanics and Analysis》2007,186(2):177-224
We prove time local existence and uniqueness of solutions to a boundary layer problem in a rotating frame around the stationary
solution called the Ekman spiral. We choose initial data in the vector-valued homogeneous Besov space for 2 < p < ∞. Here the L
p
-integrability is imposed in the normal direction, while we may have no decay in tangential components, since the Besov space
contains nondecaying functions such as almost periodic functions. A crucial ingredient is theory for vector-valued homogeneous
Besov spaces. For instance we provide and apply an operator-valued bounded H
∞-calculus for the Laplacian in for a general Banach space . 相似文献
7.
Dr. Tatsuya Takimoto Prof. Hideaki Sasaki Prof. Hirohito Tsue Dr. Hiroki Takahashi Prof. Alexander D. MacKerell Jr. Ayumi Nakamura Katsuya Nakano Eori Okazaki Tatsuki Betsuyaku Ryosuke Tachibana Dr. Kazuhito Hioki Dr. Ozge Yoluk Dr. Sunhwan Jo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(5):1648-1654
A simple approach to the synthesis of heterocyclophane consisting of two 4,4’-bithiazoles has been developed in mild conditions. The heterocyclophane with two short chains was conveniently prepared by Hantzsch thiazoles synthesis using the reaction of 3-tert-butoxycarbonyl-3-azapentanethiocarboxamide with 1,4-dibromobutane-2,3-dione in methanol under reflux for only 15 min. Amino groups at the linkers of this heterocyclophane can be functionalized to give acylated and carbamate derivatives. Their properties as protein kinase inhibitors were investigated, and one of the heterocyclophanes exhibited specific anti-activity for c-mesenchymal epithelial transition factor (IC50=603 nm ), among seven types of protein kinases investigated. The computational site identification by ligand competitive saturation method was used to determine why the one heterocyclophane exhibited strong anti-activity for c-mesenchymal epithelial transition factor. 相似文献
8.
Shuichi Hirata Kouichi Tanaka Katsuya Matsui Fernando Arteaga Arteaga Yasushi Yoshida Shinobu Takizawa Hiroaki Sasai 《Tetrahedron: Asymmetry》2013,24(19):1189-1192
The introduction of a 1,3-propanediamine unit at the 3-position of (S)-BINOL using a methylene spacer led to the formation of a chiral bifunctional organocatalyst for the aza-Morita–Baylis–Hillman (aza-MBH) reaction. The organocatalyst 1k mediated aza-MBH transformations with high chemical yields and with up to 82% ee. 相似文献
9.
Akika Futamura Asuka Uemura Takeshi Imoto Dr. Yusuke Kitamura Dr. Hirotaka Matsuura Dr. Chun‐Xia Wang Toshiki Ichihashi Dr. Yusuke Sato Prof. Dr. Norio Teramae Prof. Dr. Seiichi Nishizawa Prof. Dr. Toshihiro Ihara 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(32):10526-10535
We propose a binary fluorimetric method for DNA and RNA analysis by the combined use of two probes rationally designed to work cooperatively. One probe is an oligonucleotide (ODN) conjugate bearing a β‐cyclodextrin (β‐CyD). The other probe is a small reporter ligand, which comprises linked molecules of a nucleobase‐specific heterocycle and an environment‐sensitive fluorophore. The heterocycle of the reporter ligand recognizes a single nucleobase displayed in a gap on the target labeled with the conjugate and, at the same time, the fluorophore moiety forms a luminous inclusion complex with nearby β‐CyD. Three reporter ligands, MNDS (naphthyridine–dansyl linked ligand), MNDB (naphthyridine–DBD), and DPDB (pyridine–DBD), were used for DNA and RNA probing with 3′‐end or 5′‐end modified β‐CyD – ODN conjugates. For the DNA target, the β‐CyD tethered to the 3′‐end of the ODN facing into the gap interacted with the fluorophore sticking out into the major groove of the gap site ( MNDS and DPDB ). Meanwhile the β‐CyD on the 5′‐end of the ODN interacted with the fluorophore in the minor groove ( MNDB and DPDB ). The results obtained by this study could be a guideline for the design of binary DNA/RNA probe systems based on controlling the proximity of functional molecules. 相似文献