Chiral bifunctional organocatalysts bearing a 1,3-propanediamine unit for the aza-MBH reaction |
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| Authors: | Shuichi Hirata Kouichi Tanaka Katsuya Matsui Fernando Arteaga Arteaga Yasushi Yoshida Shinobu Takizawa Hiroaki Sasai |
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| Institution: | The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan |
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| Abstract: | The introduction of a 1,3-propanediamine unit at the 3-position of (S)-BINOL using a methylene spacer led to the formation of a chiral bifunctional organocatalyst for the aza-Morita–Baylis–Hillman (aza-MBH) reaction. The organocatalyst 1k mediated aza-MBH transformations with high chemical yields and with up to 82% ee. |
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