Substitutional, continuous solid solution of the general formula Y2–xYbxO3 was obtained from the mixture of Y2O3 and Yb2O3 oxides, for the first time by the mechanochemical method in a high-energy ball milling. The monophasic samples of nanocrystalline solid solution for x?>?0.00 and x?<?2.00 were examined by the methods: XRD, DTA, SEM, IR and UV–Vis–DR. As follows from the results, the solid solution crystallizes in cubic system and is isostructural with Y2O3 and Yb2O3. The solution is stable in the air atmosphere up to at least 900°C, and its decomposition temperature decreases with the increase in x, that is, with decreasing number of Yb3+ ions replacing Y3+ ions in the crystal lattice of Y2O3. The energy band gap estimated for the solid solution varies from?~?5.30 eV for x?=?0.50 to?~?4.90 eV for x?=?1.50, which means that it is an insulator.
The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In order to study the allosteric binding of CBD to CB1R we modeled the whole N-terminus of this receptor using the replica exchange molecular dynamics with solute tempering (REST2) approach. Then, the obtained structures of CB1R with the N terminus were used for ligand docking. A natural cannabinoid receptor agonist, Δ9-THC, was docked to the orthosteric site and a negative allosteric modulator, CBD, to the allosteric site positioned between extracellular ends of helices TM1 and TM2. The molecular dynamics simulations were then performed for CB1R with ligands: (i) CBD together with THC, and (ii) THC-only. Analyses of the differences in the residue-residue interaction patterns between those two cases allowed us to elucidate the allosteric network responsible for the modulation of the CB1R by CBD. In addition, we identified the changes in the orthosteric binding mode of Δ9-THC, as well as the changes in its binding energy, caused by the CBD allosteric binding. We have also found that the presence of a complete N-terminal domain is essential for a stable binding of CBD in the allosteric site of CB1R as well as for the allosteric-orthosteric coupling mechanism. 相似文献
The phase equilibria established in the V2O5–MoO3–α-Sb2O4 system in the solid state in an air atmosphere were examined by using XRD and DTA methods. The obtained results allowed us
to find that in this system a novel compound is formed involving three oxides. Its formula can be written as Sb3V2Mo3O21. The synthesis of this compound requires picking up the atmospheric oxygen. X-ray characteristics of this compound were determined
and it was found that it melted incongruently at 740°C. The results obtained until now allow us to divide the investigated
V2O5–MoO3–α-Sb2O4 system into five partial subsystems.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
DTA and XRD studies of the Fe2V4O13–Cr2V4 O13 system have shown that continuous solid solutions of a Fe2–xCrxV4O13 type, bearing a Fe2 V4 O13 structure, are formed in the system. With the increasing degree of the Cr3+ ion incorporation into the Fe2 V4 O13 structure, a contraction of the solid solution crystal lattice develops. Solid solutions of a Fe2–x Crx V4 O13 type melt incongruently, their melting temperature increasing from 953 to 1003 K with increase in the degree of the Cr3+ ion incorporation. The solid product of melting Fe2–x Crx V4 O13 solid solutions for 0.2<x >1.2 is the Fe1–x Crx VO4 solution phase, and for x ≤0.2 and x ≥1.4 – the Fe1–x Crx VO4 phase as well as FeVO4 or CrVO4 , respectively.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
The phase equilibria being established in the V2O5-CrVMoO7 system in the solid state and the whole component concentration range have been studied by the X-ray powder diffraction and thermal analysis methods. The measurements have shown that the V2O5-CrVMoO7 system is not a real two-component system in the subsolidus area.
Zusammenfassung Mittels Thermoanalyse und Debye-Scherrer-Verfahren wurde das Phasengleichgewicht im Feststoffsystem V2O5-CrVMoO7 im gesamten Konzentrationsbereich untersucht. Die Messungen zeigen, daß es sich bei dem System V2O5-CrMoO7 im Bereich unter Solidus um kein echtes Zweikomponentensystem handelt.
A phase diagram of the FeVO4-MoO3 system has been constructed from the results of DTA and X-ray analysis. The components of the system form a compound FeVMoO7. This compound melts incongruently at 680±5 °C, with separation of the solid Fe4V2Mo3O20. 相似文献
The interdiffusion process in thin and thick (500nm–60µm) Au–Ni layers deposited on different substrates is studied using the EDS technique. In-depth X-ray analysis based on the Pouchou and Pichoir method is applied for obtaining the concentration profiles in nanometre scale multi-layers. A theoretical analysis using the Darken method is employed for modelling interdiffusion in the Au–Ni system. Computer simulations, where intrinsic diffusivities of the Au and Ni are functions of composition, are presented and compared with experimental results. 相似文献
G‐protein‐coupled receptors (GPCRs) are involved in a wide range of physiological processes, and they have attracted considerable attention as important targets for developing new medicines. A central and largely unresolved question in drug discovery, which is especially relevant to GPCRs, concerns ligand selectivity: Why do certain molecules act as activators (agonists) whereas others, with nearly identical structures, act as blockers (antagonists) of GPCRs? To address this question, we employed all‐atom, long‐timescale molecular dynamics simulations to investigate how two diastereomers (epimers) of dihydrofuroaporphine bind to the serotonin 5‐HT1A receptor and exert opposite effects. By using molecular interaction fingerprints, we discovered that the agonist could mobilize nearby amino acid residues to act as molecular switches for the formation of a continuous water channel. In contrast, the antagonist epimer remained firmly stabilized in the binding pocket. 相似文献
Structural noise and vibrations control can be achieved
using two strategies: active - with feed-forward controller, a sensor and an
actuator [1-3] or passive, by piezoelectric shunt damping [4-8], when a piezoelectric transducer will act as a sensor
and an actuator. Potential applications of these structures are
investigated. Two numerical (FEM) models based on the active and passive
damping strategies are compared. The numerical solutions were confirmed
experimentally. 相似文献