全文获取类型
收费全文 | 4432篇 |
免费 | 123篇 |
国内免费 | 6篇 |
专业分类
化学 | 3427篇 |
晶体学 | 6篇 |
力学 | 42篇 |
数学 | 634篇 |
物理学 | 452篇 |
出版年
2019年 | 40篇 |
2018年 | 36篇 |
2017年 | 26篇 |
2016年 | 100篇 |
2015年 | 64篇 |
2014年 | 99篇 |
2013年 | 142篇 |
2012年 | 145篇 |
2011年 | 153篇 |
2010年 | 129篇 |
2009年 | 117篇 |
2008年 | 161篇 |
2007年 | 159篇 |
2006年 | 179篇 |
2005年 | 199篇 |
2004年 | 167篇 |
2003年 | 124篇 |
2002年 | 94篇 |
2001年 | 46篇 |
2000年 | 36篇 |
1998年 | 27篇 |
1997年 | 84篇 |
1996年 | 78篇 |
1995年 | 63篇 |
1994年 | 84篇 |
1993年 | 85篇 |
1992年 | 82篇 |
1991年 | 79篇 |
1990年 | 60篇 |
1989年 | 84篇 |
1988年 | 83篇 |
1987年 | 79篇 |
1986年 | 67篇 |
1985年 | 91篇 |
1984年 | 110篇 |
1983年 | 60篇 |
1982年 | 85篇 |
1981年 | 104篇 |
1980年 | 79篇 |
1979年 | 99篇 |
1978年 | 67篇 |
1977年 | 69篇 |
1976年 | 57篇 |
1975年 | 76篇 |
1974年 | 49篇 |
1973年 | 69篇 |
1972年 | 51篇 |
1971年 | 41篇 |
1970年 | 51篇 |
1967年 | 29篇 |
排序方式: 共有4561条查询结果,搜索用时 406 毫秒
1.
2.
3.
Brian R. Holder Colleen A. McNaney David Luchetti Eric Schaeffer Dieter M. Drexler 《Biomedical chromatography : BMC》2015,29(9):1375-1379
Acetyl‐l ‐carnitine (ALCAR) is a potential biomarker for the modulation of brain neurotransmitter activity, but is also present in cerebrospinal fluid (CSF). Recent studies have utilized hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC‐MS/MS) based assays to detect and quantify ALCAR within biofluids such as urine, plasma and serum, using various sample pretreatment procedures. In order to address the need to quantify ALCAR in CSF on a high‐throughput scale, a new and simple HILIC‐MS/MS assay has been successfully developed and validated. For rapid analysis, CSF sample pretreatment was performed via ‘dilute and shoot’ directly onto an advanced HILIC column prior to MS/MS detection. This newly developed HILIC‐MS/MS assay shows good recoveries of ALCAR without the need for chemical derivatization and multistep sample extraction procedures. The employment of this assay is suitable for the high‐throughput bioanalysis and quantification of ALCAR within the CSF of various animal models and human clinical studies. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
4.
Palladium‐Catalyzed Domino CH/NH Functionalization: An Efficient Approach to Nitrogen‐Bridged Heteroacenes 下载免费PDF全文
Natsuyo Kamimoto Dr. Dieter Schollmeyer Dr. Koichi Mitsudo Prof.Dr. Seiji Suga Prof.Dr. Siegfried R. Waldvogel 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(22):8257-8261
Palladium‐catalyzed domino C?H/N?H functionalization for the synthesis of novel nitrogen‐bridged thienoacenes and 10H‐benzo[4,5]thieno[3,2‐b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial C?H functionalization of the benzo[b]thiophene moiety, followed by Buchwald–Hartwig coupling. This transformation is also useful for the synthesis of highly π‐extended compounds. 相似文献
5.
Lars J. Wesenberg Erika Diehl Till J. B. Zähringer Carolin Dörr Dr. Dieter Schollmeyer Dr. Akihiro Shimizu Prof. Dr. Jun-ichi Yoshida Prof. Dr. Ute A. Hellmich Prof. Dr. Siegfried R. Waldvogel 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(72):17574-17580
The efficient production of many medicinally or synthetically important starting materials suffers from wasteful or toxic precursors for the synthesis. In particular, the aromatic non-protected primary amine function represents a versatile synthetic precursor, but its synthesis typically requires toxic oxidizing agents and transition metal catalysts. The twofold electrochemical amination of activated benzene derivatives via Zincke intermediates provides an alternative sustainable strategy for the formation of new C−N bonds of high synthetic value. As a proof of concept, we use our approach to generate a benzoxazinone scaffold that gained attention as a starting structure against castrate-resistant prostate cancer. Further improvement of the structure led to significantly increased cancer cell line toxicity. Thus, exploiting environmentally benign electrooxidation, we present a new versatile and powerful method based on direct C−H activation that is applicable for example the production of medicinally relevant compounds. 相似文献
6.
7.
8.
9.
For the numerical solution of time‐dependent partial differential equations, time‐parallel methods have recently been shown to provide a promising way to extend prevailing strong‐scaling limits of numerical codes. One of the most complex methods in this field is the “Parallel Full Approximation Scheme in Space and Time” (PFASST). PFASST already shows promising results for many use cases and benchmarks. However, a solid and reliable mathematical foundation is still missing. We show that, under certain assumptions, the PFASST algorithm can be conveniently and rigorously described as a multigrid‐in‐time method. Following this equivalence, first steps towards a comprehensive analysis of PFASST using blockwise local Fourier analysis are taken. The theoretical results are applied to examples of diffusive and advective type. 相似文献
10.
Dieter Schemeth Jean-Christophe Noël Thomas Jakschitz Matthias Rainer Richard Tessadri Christian W. Huck Günther K. Bonn 《Analytica chimica acta》2015
In this study we report the novel polymeric resin poly(N-vinyl imidazole/ethylene glycol dimethacrylate) for the purification and isolation of phenolic acids. The monomer to crosslinker ratio and the porogen composition were optimized for isolating phenolic acids diluted in acetonitrile at normal phase chromatography conditions, first. Acetonitrile serves as polar, aprotic solvent, dissolving phenolic acids but not interrupting interactions with the stationary phase due to the approved Hansen solubility parameters. The optimized resin demonstrated high loading capacities and adsorption abilities particularly for phenolic acids in both, acetonitrile and aqueous solutions. The adsorption behavior of aqueous standards can be attributed to ion exchange effects due to electrostatic interactions between protonated imidazole residues and deprotonated phenolic acids. Furthermore, adsorption experiments and subsequent curve fittings provide information of maximum loading capacities of single standards according to the Langmuir adsorption model. Recovery studies of the optimized polymer in the normal-phase and ion-exchange mode illustrate the powerful isolation properties for phenolic acids and are comparable or even better than typical, commercially available solid phase extraction materials. In order to prove the applicability, a highly complex extract of rosemary leaves was purified by poly(N-vinyl imidazole/ethylene glycol dimethacrylate) and the isolated compounds were identified using UHPLC–qTOF-MS. 相似文献