Palladium‐Catalyzed Domino CH/NH Functionalization: An Efficient Approach to Nitrogen‐Bridged Heteroacenes |
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| Authors: | Natsuyo Kamimoto Dr Dieter Schollmeyer Dr Koichi Mitsudo ProfDr Seiji Suga ProfDr Siegfried R Waldvogel |
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| Institution: | 1. Institut für Organische Chemie, Johannes Gutenberg‐Universit?t Mainz, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49)?6131?3926777 http://www.chemie.uni‐mainz.de/OC/AK‐Waldvogel/;2. Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3‐1‐1 Tsuhsima‐naka, Kita‐ku, Okayama 700‐8530 (Japan) http://achem.okayama‐u.ac.jp/reacteng/lang/en |
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| Abstract: | Palladium‐catalyzed domino C?H/N?H functionalization for the synthesis of novel nitrogen‐bridged thienoacenes and 10H‐benzo4,5]thieno3,2‐b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial C?H functionalization of the benzob]thiophene moiety, followed by Buchwald–Hartwig coupling. This transformation is also useful for the synthesis of highly π‐extended compounds. |
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| Keywords: | amination C H activation domino reactions heterocycles palladium |
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