A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy

Background  

Fully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progressive disease. We attempted to augment fully functional HIV-1-specific CD8 and CD4 effector T-cell responses in patients with advanced chronic HIV-1 infection.     

Quantitative chemical analysis of electrolytes in aqueous solutions exploiting the Donnan dialysis process

Chemical analysis of electrolytes in aqueous solutions is performed with a dialyzer consisting of two selective membranes: a cation and an anion-exchange membrane. The dialyzer actually functions like a galvanic cell when dialysis is carried out. The current that appears in the cell is measured. Since the dialysis process is caused by the concentration gradient, the current measured also depends on the concentration gradient. For proper conditions, it becomes possible to determine the concentration. The method may compete in some aspects with ion-selective potentiometry. The text was submitted by the authors in English.     

Femtosecond vibrational dynamics of self-trapping in a quasi-one-dimensional system

We have directly time resolved the lattice motions associated with the formation of the self-trapped exciton in the quasi-one-dimensional system [Pt(en)(2)] [Pt(en)2Br2];(PF6)(4) ( en = ethylene-diamine, C2H8N2), using femtosecond impulsive excitation techniques. A strongly damped, low-frequency wave packet modulation at approximately 110 cm(-1) accompanies the formation of the self-trapped exciton on a approximately 200 fs time scale following excitation of the intervalence charge-transfer transition. Coherent oscillations at the ground state vibrational frequency and its harmonics are also detected.     

Flow injection analysis with amperometric detection for measurements of proton activities in solutions of strong acids and strong bases

 Flow injection and reversed flow injection analysis with amperometric detection were used for the determination of the concentrations of strong acids and strong bases and the pH of the solutions. The amperometric detection was based on the reduction current of hydrogen ion or water molecules. A platinum indicator electrode cathodically polarized at a constant potential was employed, choosing the potential in the rising part of the current/potential curve. On the basis of the experimental data an equation was developed for the calculation of the concentrations of the strong acids and strong bases and the pH by a non-linear regression computer program. Received: 26 October 1995/Revised: 3 April 1996/Accepted: 14 April 1996     

Spectral Asymptotics for Higher-Order Ordinary Differential Equations

This paper gives one-term componentwise asymptotics for theM and spectral matrices of a self-adjoint realisation of aneven-order ordinary differential expression. The underlyinginterval is assumed to have at least one regular endpoint, andthe boundary conditions are supposed to be separated. Furthermore,the weight function and the reciprocal of the highest-ordercoefficient are supposed to be of regular variation at the regularendpoint, in the sense of Bingham, Goldie and Teugels. 1991Mathematics Subject Classification: 34B24, 34E05.     

TRPM5-expressing microvillous cells in the main olfactory epithelium

Background  

The main olfactory epithelium (MOE) in the nasal cavity detects a variety of air borne molecules that provide information regarding the presence of food, predators and other relevant social and environmental factors. Within the epithelium are ciliated sensory neurons, supporting cells, basal cells and microvillous cells, each of which is distinct in morphology and function. Arguably, the least understood, are the microvillous cells, a population of cells that are small in number and whose function is not known. We previously found that in a mouse strain in which the TRPM5 promoter drives expression of the green fluorescent protein (GFP), a population of ciliated olfactory sensory neurons (OSNs), as well as a population of cells displaying microvilli-like structures is labeled. Here we examined the morphology and immunocytochemical properties of these microvillous-like cells using immunocytochemical methods.     

Titrimetric analysis with adding the titrant by means of electrodialysis

A titration method is developed that titrant is added continuously to the analyte by electromigration through an ion exchange membrane. A constant rate of the titrant addition is achieved by keeping the electric current constant. Analyte amount then is proportional to the titration time. The method is applied to the most widely used titrations with a visual end point indication.