抗肿瘤药物在金属有机骨架中的装载及体外释放

以三乙胺直接加入法制备金属-有机骨架MOF-5, 采用X射线粉末衍射(XRD), 红外光谱(IR)和热重分析(TG)对所得样品进行表征. 分别以辣椒素和5-氟尿嘧啶(5-Fluouourail, 5-FU)为模型药物, 研究了MOF-5对2种药物的载药及体外释药性能. 通过将所得样品的XRD和IR谱图与标准谱图比对确定了样品的结构. TG结果表明, 所制备的MOF-5热稳定性良好. MOF-5对辣椒素的最高载入量达0.592 g/g载体, 对5-FU的最高载入量为0.315 g/g载体, 两种载药体系的体外释药均为明显的两相模式. 体外细胞毒性实验结果表明, MOF-5具有良好的生物相容性.     

Oscillations in Total Photodetachment Cross Sections of a Triatomic Anion

The total photodetachment cross section of a linear triatomic anion is derived for arbitrary laser polarization direction. The cross section is ,shown to be strongly oscillatory when the laser polarization direction is parallel to the axis of the system; the oscillation amplitude decreases and vanishes as the angle between the laser polarization and the anion axis increases and becomes perpendicular to the axis. The average cross section over the orientations of the triatomie system is also obtained. The cross section of the triatomic anion is compared with the cross section of a two-center system. We find there are two oscillation frequencies in the triatomie anion in contrast to only one oscillation frequency in the two-center case. Closed-orbit theory is used to explain the oscillations.