| 抗肿瘤药物在金属有机骨架中的装载及体外释放 |
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| 引用本文： | 杨宝春,姜耀东,秦雪娟,陈志良,任非.抗肿瘤药物在金属有机骨架中的装载及体外释放[J].高等学校化学学报,2012,33(1):26-31. |
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| 作者姓名： | 杨宝春 姜耀东 秦雪娟 陈志良 任非 |
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| 作者单位： | 1. 南方医科大学南方医院药学部,广州,510515
2. 南方医院泌尿外科,广州,510515 |
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| 基金项目： | 广东省科技计划，南方医院院长基金 |
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| 摘 要： | 以三乙胺直接加入法制备金属-有机骨架MOF-5, 采用X射线粉末衍射(XRD), 红外光谱(IR)和热重分析(TG)对所得样品进行表征. 分别以辣椒素和5-氟尿嘧啶(5-Fluouourail, 5-FU)为模型药物, 研究了MOF-5对2种药物的载药及体外释药性能. 通过将所得样品的XRD和IR谱图与标准谱图比对确定了样品的结构. TG结果表明, 所制备的MOF-5热稳定性良好. MOF-5对辣椒素的最高载入量达0.592 g/g载体, 对5-FU的最高载入量为0.315 g/g载体, 两种载药体系的体外释药均为明显的两相模式. 体外细胞毒性实验结果表明, MOF-5具有良好的生物相容性.
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| 关 键 词： | 金属-有机骨架 辣椒素 5-氟尿嘧啶 载药量 药物缓释 细胞毒性 |
| 收稿时间： | 2011-05-04 |
Loaded and in vitro Drug Release of Anticancer Drugs in Porous Metal-Organic Frameworks |
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| YANG Bao-Chun
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JIANG Yao-Dong
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QIN Xue-Juan
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CHEN Zhi-Liang
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REN Fei.Loaded and in vitro Drug Release of Anticancer Drugs in Porous Metal-Organic Frameworks[J].Chemical Research In Chinese Universities,2012,33(1):26-31. |
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| Authors: | YANG Bao-Chun JIANG Yao-Dong QIN Xue-Juan CHEN Zhi-Liang REN Fei |
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| Institution: | 1*(1.Department of Pharmacy,2.Urology Nanfang Hospital,Southern Medical University,Guangzhou 510515,China) |
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| Abstract: | Porous metal-organic frameworks(MOF-5) were synthesized and the structure of synthetic MOF-5 was confirmed by XRD and IR spectrum.According to the result of TG,the synthetic MOF-5 displayed better thermo-stabilization.The capsaicin or 5-fluouourail was loaded in synthetic MOF-5 and in vitro drug release profile were investigated,respectively.The highest drug loading rates are 0.592 g/g MOF for capsaicin and 0.315 g/g MOF for 5-FU in drug-loaded MOF-5,respectively.The in vitro drug release profile of both MOF-5 formulations showed a clear biphasic release pattern.Cytotoxicity test showed that MOF-5 displayed good biocompatility. |
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| Keywords: | Metal-organic framework(MOF) Capsaicin 5-Fluouourail(5-FU) Drug loading rate Drug sustained release Cytotoxicity |
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