A New Sesquiterpene Lactone from Ainsliaea bonatii

A new sesquiterpene lactone, Ainsliaolide A, was isolated from Ainsliaea bonatii. The structure was determined on the basis of spectral data.     

A New Asterosaponin from the Starfish Culcita novaeguineae

A new asterosaponin named novaeguinoside A, along with a known saponin, asteronyl pentaglycoside sulfate, was isolated from the starfish Culcita novaeguineae. The new compound was identitied to be sodium 6α-O-{β-D-fucopyranosyl-(1→2)-β-D-fucopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-xylopyranosyl-(1→3)-[β-D-quinovopyranosyl}-5α-pregn-9(11)-en-20-one-3β-yl-sulfate by extensive spectral analysis and chemical evidence.     

A Novel Total Synthesis of (±)Shikonin

Shikonin 1 was a key component isolated from the traditional Chinese herbal medicine, Zicao(Lithospermum erythrorhizon Sieb.et Zucc), which possesses multiple biological activities1. There have been many synthetic routes to shikonin, however, all these ro…     

化学模式识别技术评价中药厚朴质量的研究

本文对不同产地和市售的二十四种厚朴药材及饮片的萃取液进行了高效液相色谱、气相色谱及紫外光谱分析;对所得数据用主成分分析进行分类,概括出不同样品化学成分的异同,认为大叶木兰可做为厚朴的代用品,而在陕西安康购得的样品不应做厚朴使用,后者经生药学鉴定为厚朴伪品凹叶木兰。化学模式识别技术可为寻找药材的代用品、评价中药质量及鉴定伪劣药材提供依据。     

Design,synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors,with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step.The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test(OGTT),and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.     

Two Chiral Building Blocks for the Stereocontrolled Synthesis of Anti-and Syn-1,3-Diols

During the last decade, chiral building blocks for 1, 3-diols of various configurations have been synthesized and applied widely in the total synthesis of natural polyene macrolide antibiotics1 and 1(, 25-dihydroxyvitamin D3 analogues2,3. The synthesis of the building block has attracted much interest in recent years. Herein, we report the synthesis of two chiral building blocks 1 and 2 in 8 steps and 7 steps respectively, starting from the readily available and inexpensive D (+)-xylose 3 as o…     

Two new secoiridoid glucosides from Syringa velutina Kom

Chemical investigation of Syringa velutina Kom. led to the isolation of two new secoiridoid glucosides. Their structures were identified as 6'-0-(6, 7-dihyrofoliamenthoyl)-8-epi-kingisidic acid (syrveoside A, 1) and 6'-O-menthiafoloyl-8-epi-kingisidic acid (syrveoside B, 2) on the basis of chemical and physicochemical evidence.     

Two new eudesmane derivatives from Verbesina virginica

<正>Two new eudesmane derivatives were isolated from the leaves and flowers of Verbesina virginica,along with the known 6-O-β-E -p-coumaroyl-4α-hydroxyeudesmane(1).Their structures were determined as 6-O-β-Z-p-coumaroyl-4α-hydroxyeudesmane(2) and 6-O-α-E-p-coumaroyl-1β-4α-dihydroxyeudesmane(3) by spectroscopic methods.     

Two New Steroidal Saponins from Diuranthera inarticulata

There are only three species in the genus Diuranthera (Liliaceae), which is endemic in the southwest of China1. Four steroidal saponins, diuranthosides A-C and chloromalo-side A were isolated from the fresh roots of D. major. This paper deals with the structure elucidation of two new steroidal saponins, diuranthosides D and E, which were isolated from the methanolic extract of whole plant of D. inarticulata Wang et K. Y. Lang.Diuranthoside D (1), [(]-38 (c 0.08, pyridine), afforded galac…     

Melamine-(H_2SO_4)_3 and PVP-(H_2SO_4)_n as solid acids:Synthesis and application in the first mono-and di-nitration of bisphenol A and other phenols

Melamine and poly vinylpyrrolidone（PVP） reacted with neat sulfuric acid readily to form two new organic solid acids namely melamine-（H₂SO₄）₃ and PVP-（H₂SO₄）_n.These solid acids were used for the first nitration of bisphenol A as well as other phenols in the presence of NH₄NO₃.Mono- and di-nitro bisphenol A have been characterized with IR and ¹H NMR techniques.