[1-芳基甲羰基-2-(1,2,4-三唑-1-基)]乙基-N,N-二烷基二硫代氨基甲酸酯衍生物的合成、结构表征及生物活性研究

以芳香基三唑类杀菌剂三唑酮为先导物设计并合成了5个含N,N-二烷基二硫代氨基甲酸酯的芳香三唑类化合物, 通过元素分析、红外光谱、核磁共振氢谱和质谱对其结构进行了表征. 用X射线单晶衍射测定了[α-(4-甲氧基苯甲酰基)-2-(1,2,4-三唑-1-基)]乙基-N,N-二甲基二硫代氨基甲酸酯的晶体结构, 晶体属于三斜晶系, 空间群, 晶胞参数为: a＝0.73482(15) nm, b＝1.1051(2) nm, c＝1.1209(2) nm, α＝90.32(3)°, β＝101.97(3)°, γ＝105.13(3)°, V＝0.8578(3) nm³, Z＝2, D_c＝1.357 g/cm³, F(000)＝368, µ＝0.324 mm^－1. 生物测试结果显示这5种有机化合物都具有杀菌性和植物生长调节活性     

含芳硫基的新三唑类化合物的合成及生物活性研究

许多三唑类化合物具有优良的杀菌和植物生长调节活性 ,如三唑酮、三唑醇、烯效唑、烯唑醇等 ,对常见真菌病害具有很好的防治效果 ,并具有增产、抗倒和生长调节作用 ,已成为重要的杀菌剂类型 [1] .为筛选新型高活性三唑类杀菌剂和探讨其活性与结构间的关系 ,我们利用生物等排体理论以常规三唑类杀菌剂三唑酮为先导物设计合成了 1 6个含芳硫基的新三唑类化合物 ,其合成路线如下 :RCCH2 BrO+HNNNB NRCCH2O NNHAC-Na ACBr2NRCCHOBrNN(1 ) (2 ) (3 )3 +SH 　R′B NRCCHOS　R′NN　 (4 )RCCH2 CH2 NMe2 .HClO+HNNNH2 O…     

Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing N,N-Dialkyldithiocarbamate Moiety

Introduction As an important type of fungicides, triazole compounds are highly efficient, low poisonous and inward absorbent.1-3 At present, the studies on triazole derivatives are mainly concentrated on compounds with triazole as the only active group. The report of triazole compounds that contain both triazole group and other active group in a single molecule has rarely been found. Dialkyl-substituted dithiocarbamate salts have also shown interesting biological effects.4 N,N-Dialkyldithio-…     

含三唑二硫代膦酸酯及硫代(或二硫代)磷酰胺酯类衍生物的研究

近年来,分子中含有1,2,4-三唑的非有机磷化合物作为杀菌剂和植物生长调节剂已受到广泛重视.为进一步开发有机磷和三唑类农药新品种,科学工作者合成了含三唑的有机磷化合物,发现某些化合物对植物的白粉病及锈病具有较强的生理活性,故进一步合成和研究各类新型含三唑的有机磷化合物具有较大的意义。作者曾报道某些含三唑的二硫代磷酸酯类化合物的合成及生物活性,发现某些化合物具有一定的杀菌、除草及调节植物生长作用.     

Crystal Structure and Spectral Characters of 2-（4-Methylbenzoly）-3-（4-chlrolphenyl） -4-（1,2,4-triazole）-5-anilino-thiopene

1 INTRODUCTION The triazole derivatives were widely studied because they represent the largest group of modern fungicides and extensively used in both human and veterinary therapy and in agriculture[1～3]. For exam- ple, there are commercially available …     

含氟对称1-芳基-1,1-双酰胺类化合物的制备及其晶体结构研究

本文通过室温下三氟乙酰胺、一溴二氟乙酰胺或含氟的苯甲酰胺与芳醛在三氟甲磺酸和亚硫酰氯存在下的反应,高产率的制备了含氟对称1-芳基-1,1-双酰胺类化合物(RfCONH)2CHAr 。化合物3aa和3ab的结构通过X-射线衍射分析得到进一步确证。     

Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing 4,6-Dimethyl-pyrimidin-2-ylthio Group

Introduction As an important type of fungicides, triazole com-pounds are highly efficient, low poisonous and inward absorbent.1-3 At present, the studies on triazole deriva-tives are mainly concentrated on compounds with tria-zole as the only active group. The report on triazole compounds that contain both triazole group and other active group in a single molecule has rarely been found. Some pyrimidines have been used as highly efficient and lowly poisonous fungicides4 in controling powdery mi…     

螺环季酮酸的羧酸酯衍生物的合成及其杀螨活性

采用类同合成、活性亚结构拼接方法,对螺环季酮酸类杀虫杀螨剂Spirodiclofen进行设计修饰,合成了18种螺环季酮酸羧酸酯的新衍生物,结构经1H NMR、IR和元素分析确证,并用X射线单晶衍射测定了化合物6d的晶体结构。 通过其生物活性测试,探讨了其构效关系。     

含三氮唑的硫代(或二硫代)氨基磷酸酯类衍生物研究

合成了７种含三氮唑的硫代（或二硫代）氨基磷酸酯衍生物。通过元素分析、ＩＲ及１ＨＮＭＲ确证了化合物的结构。生物活性测试结果表明，这些化合物均有一定的杀菌、除草和植物生长调节活性。     

含噻二唑的新型三氮唑化合物的合成、结构表征及生物活性研究

The two compounds 1-[1-（2＇,4＇-dichlorobenzoyl）-1-（3-phenylthiazoidin-2-ylidene）methyl]-1,2,4-triazole （3a） and 1-[1-（4＇-fluorobenzoyl）-1-（3-phenylthiazolidin-2-ylidene）methyl]-1,2,4-triazole （3b） were prepared by reaction of phenyl isothiocyanate, 1,2-dibromoethane with a-（1,2,4-triazol-1-yl）-substituted-acetylbenzene. Their structures were identified by means of elemental analysis, IR, and ^1H NMR spectra. The single crystal of compound 3b was also obtained. It crystallizes in triclinic system with space group P1 and a=0.9390（2） nm, b=0.9661（2） nm, c= 1.0929（2） nm, α=111.53（3）°, β= 100.46（3）°, γ= 102.08（3）°, Z=2, V=0.8647（3） nm^3, Dc= 1.407 g/cm^3,μ =0.213 mm^-1, F（000）=380, final R1=0.073. There is obvious potentially weak C-H…Y （Y=N, F, O） intermolecular interaction between the molecules in the crystal lattice, which stabilizes the crystal structure. The result of the biological test showed that the two compounds have certain fungicidal activities.