Progress in DNA Aptamers as Recognition Components for Protein Functional Regulation

Proteins play a central role in all domains of life, and precise regulation of their activity is essential for understanding the related biological processes and therapeutic functions. Nucleic acid aptamers, the molecular recognition components derived from systematic evolution of ligands by exponential enrichment(SELEX), can specifically identify proteins with antibody-like recognition characteristics and help to regulate their activity. This minireview covers the SELEX-based selection of protein-binding aptamers, membrane protein analytical techniques based on aptamer-mediated target recognition, aptamer-mediated functional regulation of proteins, including membrane receptors and non-membrane proteins(thrombin as a model), as well as the potential challenges and prospects regarding aptamer-mediated protein manipulation, aiming to supply some useful information for researchers in this field.     

自然数幂方和用二项系数表示的系数公式

得到了自然数幂方和由二项系数表示的系数a_i~(k)的公式,和由排列数表示的系数b_i~(k)的公式,证明了系数存在唯一性及系数间的若干重要性质,给出了计算系数的C-语言程序.     

具交叉感染的流行病模型的数学分析

In this paper,an initial boundary value problem with homogeneous Neumann boundary condition is studied for a reaction-diffusion system which models the spread of infectious diseases within two population groups by means of self and criss-cross infection mechanism. Existence,uniqueness and boundedness of the nonnegative global solution (u1,u2,u3,u4),existence of the limit of the solution as t→+∞,namely,(u1,u2,u3,u4)→(u*1,0,u*3,0),are proved.     

Exponential stability of Takagi-Sugeno fuzzy systems with impulsive effects and small delays

This paper deals with the exponential stability of impulsive Takagi-Sugeno fuzzy systems with delay. Impulsive control and delayed fuzzy control are applied to the system, and the criterion on exponential stability expressed in terms of linear matrix inequalities （LMIs） is presented.     

New robust chaotic system with exponential quadratic term

This paper proposes a new robust chaotic system of three-dimensional quadratic autonomous ordinary differential equations by introducing an exponential quadratic term. This system can display a double-scroll chaotic attractor with only two equilibria, and can be found to be robust chaotic in a very wide parameter domain with positive maximum Lyapunov exponent. Some basic dynamical properties and chaotic behaviour of novel attractor are studied. By numerical simulation, this paper verifies that the three-dimensional system can also evolve into periodic and chaotic behaviours by a constant controller.     

Global Optimization Algorithm for the Nonlinear Sum of Ratios Problem

This article presents a branch-and-bound algorithm for globally solving the nonlinear sum of ratios problem (P). The algorithm economizes the required computations by conducting the branch-and-bound search in ^p, rather than in ⁿ, where p is the number of ratios in the objective function of problem (P) and n is the number of decision variables in problem (P). To implement the algorithm, the main computations involve solving a sequence of convex programming problems for which standard algorithms are available.     

Exact Buffer Overflow Calculations for Queues via Martingales

Let _n be the first time a queueing process like the queue length or workload exceeds a level n. For the M/M/1 queue length process, the mean _n and the Laplace transform e^-sn is derived in closed form using a martingale introduced in Kella and Whitt (1992). For workload processes and more general systems like MAP/PH/1, we use a Markov additive extension given in Asmussen and Kella (2000) to derive sets of linear equations determining the same quantities. Numerical illustrations are presented in the framework of M/M/1 and MMPP/M/1 with an application to performance evaluation of telecommunication systems with long-range dependent properties in the packet arrival process. Different approximations that are obtained from asymptotic theory are compared with exact numerical results.     

The Entrance Laws of Self-Similar Markov Processes and Exponential Functionals of Lévy Processes

We consider the asymptotic behavior of semi-stable Markov processes valued in ]0,[ when the starting point tends to 0. The entrance distribution is expressed in terms of the exponential functional of the underlying Lévy process which appears in Lamperti's representation of a semi-stable Markov process.     

Direct sums of local torsion-free abelian groups

The category of local torsion-free abelian groups of finite rank is known to have the cancellation and -th root properties but not the Krull-Schmidt property. It is shown that 10 is the least rank of a local torsion-free abelian group with two non-equivalent direct sum decompositions into indecomposable summands. This answers a question posed by M.C.R. Butler in the 1960's.