Sonoporation-mediated transduction of siRNA ameliorated experimental arthritis using 3 MHz pulsed ultrasound

The goal of this feasibility study was to examine whether sonoporation assisted transduction of siRNA could be used to ameliorate arthritis locally. If successful, such approach could provide an alternative treatment for the patients that have or gradually develop adverse response to chemical drugs. Tumor necrosis factor alpha (TNF-α) produced by synovial fibroblasts has an important role in the pathology of rheumatoid arthritis, inducing inflammation and bone destruction. In this study, we injected a mixture of microbubbles and siRNA targeting TNF-α (siTNF) into the articular joints of rats, and transduced siTNF into synovial tissue by exposure to a collimated ultrasound beam, applied through a probe 6 mm in diameter with an input frequency of 3.0 MHz, an output intensity of 2.0 W/cm² (spatial average temporary peak; SATP), a pulse duty ratio of 50%, and a duration of 1 min. Sonoporation increased skin temperature from 26.8 °C to 27.3 °C, but there were no adverse effect such as burns. The mean level of TNF-α expression in siTNF-treated knee joints was 55% of those in controls. Delivery of siTNF into the knee joints every 3 days (i.e., 7, 10, 13, and 16 days after immunization) by in vivo sonoporation significantly reduced paw swelling on days 20–23 after immunization. Radiographic scores in the siTNF group were 56% of those in the CIA group and 61% of those in the siNeg group. Histological examination showed that the number of TNF-α positive cells was significantly lower in areas of pannus invasion into the ankle joints of siTNF- than of siNeg-treated rats. These results indicate that transduction of siTNF into articular synovium using sonoporation may be an effective local therapy for arthritis.     

Design and simulation of a C-band SLED with mode converter

The transient response analysis of the SLED based on the equivalent circuit is described. Then, a C-band SLED using TE0,1,15 mode cylindrical cavity with TE10-TE01 mode converter has been designed. According to the main RF parameters of the accelerator, the coupling coefficient is optimized to obtain the maximum multiplication factor. The key components of the pulse compressor include a 3 dB directional coupler, a TE10-TE01 mode converter,and a cylindrical cavity, which are simulated and optimized using 3D electromagnetic field simulation software. In addition, the function defining the relation between the coupling factor and aperture size is derived by a mathematical fitting method.     

Magnetic properties of two-dimensional charged spin-1 Bose gases

Within the mean-field theory, we investigate the magnetic properties of a charged spin-1 Bose gas in two dimensions. In this system the diamagnetism competes with paramagnetism, where the Landé factor g   is introduced to describe the strength of the paramagnetic effect. The system presents a crossover from diamagnetism to paramagnetism with the increasing of the Landé factor. _gc$g_c$ denotes the critical value of the Landé factor. We get the same value of _gc$g_c$ both in the low temperature and strong magnetic field limit. Our results also show that in very weak magnetic field no condensation happens in the two-dimensional charged spin-1 Bose gas.     

SKLOF:一种新的超新星候选范围约减算法

超新星是宇宙学中的“标准烛光”, 其在星系中爆发的概率很低, 是一种特殊、稀少的天体, 只有在大量观测的星系数据中才有机会遇到, 而正处于爆发期的超新星会照亮其整个星系从而在观测获得的星系光谱中具有较明显的特征。但是, 目前已发现的超新星数量相对于大量的天体而言又是非常稀少的, 搜寻它们所用的计算时间成为能否进行后续观测的关键, 因此需要寻找高效率的超新星搜寻方法。对超新星候选范围进行约减的LOF算法的时间复杂度较高, 计算量大, 不适用于大规模数据集。为此通过对LOF算法进行改进, 提出了一种在海量星系光谱中快速约减超新星候范围的新方法(SKLOF)。首先对光谱数据集中离中心点近的数据点进行数据剪枝, 剪掉那些肯定不是超新星候选体的光谱数据对象, 然后利用改进的LOF算法计算剩余的光谱数据的孤立性因子并降序排列进行离群搜索, 最后获得超新星候选体的较小的搜索范围以便进行后续的证认。实验结果表明, 该算法十分有效, 不仅在精确度上有所提高, 而且相比于LOF算法还进一步缩短了算法的运行时间, 提高了算法的执行效率。     

非对称倾侧亚晶界的晶体相场法研究

采用晶体相场法研究非对称倾侧亚晶界结构及其在应力作用下的微观运动机制.分别从温度、倾斜度角以及应力施加方向等方面对其结构及迁移过程进行分析和讨论.结果表明,非对称倾侧亚晶界由符号相同的一排刃型位错等距排列,部分出现由两个相互垂直排列的刃型位错构成的位错组;在应力作用下,非对称倾侧亚晶界迁移的微观机制包括位错的滑移和攀移、位错组分解、单个位错与位错组反应、单个位错分解以及位错湮灭;温度降低和倾斜度增大都会阻碍亚晶界的迁移过程;应力方向改变导致位错运动方向改变,从而改变晶界迁移形式.     

光束相干合成中填充因子对远场光强分布的影响

理论推导了相干光束阵列远场光强分布的解析表达式.介绍了填充因子及五种相干合成效果评价参数的定义.分析了填充因子对远场光强分布的影响,发现填充因子通过影响空间调制因子来改变远场光强分布.求得了相干合成效果评价参数与填充因子的关系式,并绘制了关系曲线.计算结果表明,斯特列尔比与填充因子无关,恒为1;中央主瓣半径与填充因子成正比关系;中央主瓣能量密度受填充因子的影响较小;中央主瓣能量比与填充因子的平方成近似正比关系;桶中功率与填充因子的关系很复杂,但总体上随着填充因子的√减小而减小.分析显示,若要保证中央主瓣能量比和PIB值均大于最佳值的一半,则填充因子应大于2/2.     

20世纪90年代末东亚夏季降水年代际变化及其成因初探

基于1983—2011年月总降水量、环流和海温的再分析资料,给出了20世纪90年代末东亚夏季降水的年代际调整的区域特征,及其对应的大气环流内部过程和可能的海温外强迫的年代际变化.研究结果表明,在20世纪90年代末期东亚北部夏季降水比东亚南部夏季降水由湿向干的表现更为明显,东亚南部地区夏季降水则是在20世纪90年代初和21世纪初发生年代际的转折.此外,东亚地区夏季的500 h Pa高度场、850 h Pa风场、U200风场、水汽输送场和东亚太平洋遥相关型指数和东亚夏季风指数等在20世纪90年代末期也表现出明显的年代际变化特征.进而从大气内部过程的角度验证了20世纪90年代末东亚夏季降水发生的年代际调整.与此同时,北太平洋和西太平洋海表温度表现出由偏低向偏高的转变,这可能是导致20世纪90年代末期东亚夏季气候年代际变化的重要外部成因之一.     

一种平行背栅极碳纳米管阵列的场增强因子计算

建立一种平行背栅极碳纳米管阵列阴极,基于电场叠加原理,利用镜像电荷法对其进行计算,给出碳纳米管顶端表面电场增强因子。在此基础上,进一步分析器件各类参数对电场增强因子的影响。分析表明,碳纳米管阵列阴极具有最佳阵列密度,其对应碳纳米管间距大约为碳纳米管高度的两倍,靠阴极阵列边缘部位的碳纳米管发射电子能力比其中心部位的大。除了碳纳米管的长径比之外,栅极宽度、栅极厚度和栅极间距等也对电场增强因子有一定的影响:栅极越宽,场增强因子越大;而栅极厚度、栅极间距越大,场增强因子就越小。     

MIM结构的SPP模式理论与仿真计算研究

为了进一步明确MIM （Metal-insulator-metal）波导结构的SPP （Surface plasmon polariton）模式特性,建立了MIM结构的SPP模式关系、激发系数和反射系数的理论模型。仿真数值计算结果表明：较大的介质厚度的TM基态模式衰减超过了振荡模式衰减,与传统的介质波导明显不同;TE模式表现为失真的介质光波导模式特性,其传播距离要远大于TM₀;MIM结构中腔的Q值随着长度增加而增大,表明了SPP反射受限;腔的品质因数改变与端面关系密切;MIM波导可以在具有更大Q值下确保光波更好地耦合成需要的SPP模式。     

C波段能量倍增器的研制

C波段(5712 MHz)能量倍增器——SLED是我国研制的首台C波段能量倍增器。简述了利用三维电磁场仿真软件HFSS和CST对C波段能量倍增器的高品质因数储能腔、耦合孔、3 dB桥等进行优化设计的情况,对加工的能量倍增器做了射频低功率测试,实验测试和理论计算的一致性很好,测试结果表明所有技术参数指标均达到了设计要求。