阳虚体质者血清和尿液的核磁共振代谢组学

采用基于核磁共振(NMR)的代谢组学方法研究了中医阳虚体质及平和体质(正常对照)的血清和尿液, 分析了阳虚体质的特征代谢物. 实验收集阳虚体质及平和体质各30人的血清及尿液样品, 采用多元统计分析方法研究了阳虚质组和对照组血清和尿液中的内源性代谢差异. 结果表明, 阳虚质血清中乳酸、 极低密度脂蛋白/低密度脂蛋白、N-乙酰糖蛋白、脂肪酸及不饱和脂肪酸的含量降低, 谷氨酰胺、葡萄糖、磷脂酰胆碱及高密度脂蛋白的含量增多; 尿液中肌酐的含量降低, 乳酸、二甲胺、柠檬酸及马尿酸的含量增多. 阳虚体质的潜在生物标志物的发现从代谢组学角度为个体差异提供了新的依据. 阳虚体质与平和体质存在能量代谢、脂代谢及糖代谢的差异以及相关脏腑功能的改变.     

雅砻江锦屏一级水电站坝址区实测地应力与重大工程地质问题分析

本文对雅砻江锦屏一级水电站坝址区Ⅱ1-Ⅱ1及其前后剖面实测地应力进行了系统整理分析。分析结果表明:在相同的水平和垂直埋深条件下左岸坡角应力大小较右岸坡角小,这主要是由边坡岩体结构确定的;左岸导流洞开挖过程中在应力大小较右岸低的情况下出现坍塌工程地质问题也与左岸边坡岩体结构有关,而非岩爆等诱发。另外对左岸岩体深部裂缝在已有研究成果的基础上从应力集中、能量积累角度初步提出了新的边坡变形破坏方式,并从岩体结构和地应力大小方面对锦屏一级水电站工程建设过程中左、右岸应注意的工程地质问题提出了初步建议。     

Preparation and magnetic properties of ultrafine particles of FeNi alloys

Ultrafine particles (UFP) of six kinds of FeNi alloys were synthesized by the method of hydrogen plasma reaction. The prepared UFP samples were examined by X-ray diffraction, electron transmission microscopy and magnetic measurement. The spherical FeNi UFP alloys with a mean particle size less than 35 nm can be prepared with a production rate much higher than by conventional methods. The phase constitution of UFP alloys is different from the equilibrium phase diagram owing to rapid condensation of evaporated metal gases. Although the magnetization for the UFP alloys has almost the same temperature dependence as that of the bulk alloys, the saturation magnetization remarkably decreases as the bulk alloys change into the UFP alloys.     

高职化工创新型人才培养体系的构建与实践

按照高职教学规律,说明了高职创新型人才培养的必要性,并进行了高职化工专业创新型人才体系的构建实践,探讨了化工创新型人才培养经验。     

What is the basic chromophore of a dye?

Taking the 4,5-diphenyl-substituted 2-dimethylamino-3-azacyclopentadienone (4) as an example its colour has been discussed in relation to different basic chromophores (parent chromophores). The parent chromophore can be defined either as the structure which has nearly the same absorption wavelength as the dye under consideration or as the substructure which is electronically most closely related to the dye. In the case of4 both considerations lead to different results. Based on the correlation diagram between the electronic states involved in the electronic excitation the long-wavelength absorption of4 is better understood in terms of the merocyanine parent chromophore than in terms of a betainic substructure, which should have the same colour as4 and is the parent chromophore according toKlessinger. This conclusion is drawn fromPPP configuration analysis of the wavefunctions of4 relative to different molecular substructures. The molecular geometry predicted by the geometry-optimized MINDO/3 and QCFF/Pi calculations provided additional arguments in favour of the cyclomerocyanine structure of4. In respect to the colour4 belongs to a new series of cyclic-conjugated chromophoric systems.     

A Semantic Resolution of the Paradox of Analysis

The paradox of analysis has been a problem for analytic philosophers at least since Moore’s time, and it is especially significant for those who seek an account of analysis along classical lines. The present paper offers a new solution to the paradox, where a theory of analysis is given where (1) analysandum and analysans are distinct concepts, due to their failing to share the same conceptual form, yet (2) they are related in virtue of satisfying various semantic constraints on the analysis relation. Rather than distinguish between analysandum and analysans by appeal to epistemic considerations, the paper appeals to semantic considerations in giving a candidate account of the identity conditions for concepts. The distinctness of analysandum and analysans then serves to block the paradox in a straightforward way.

快速凝固Ti-Cu-Fe合金的相组成与组织演变规律

采用落管无容器处理技术实现了Ti_61.2Cu_32.5Fe_6.3三元包共晶合金在自由落体条件下的快速凝固,获得了直径为80—1120μm液滴的凝固组织.实验中获得的过冷度范围为34—293 K,最大过冷度达0.23T_L.研究发现,在自由落体条件下,由于受到无容器、微重力、超高真空等因素的影响,合金熔体的凝固组织中包含Cu_0.8Fe_0.2Ti相、CuTi₂相和CuT₃相,显著偏离了平衡状态.Cu_0.8Fe_0.2Ti为初生相,同时又与CuTi₂相形成两相共晶;CuTi₃相则呈现枝晶形貌,并发生了明显的溶质截留效应.随着过冷度的增大,共晶组织由层片共晶向不规则共晶转变,形貌由长条状共晶团变为椭球状共晶团,最终变为球状共晶胞;Cu_0.8Fe_0.2Ti相枝晶形貌由粗大枝晶变为碎断枝晶,进一步变成不规则的粒状晶粒;CuTi₃相枝晶则由碎块状转变为完整枝晶.     

乳腺组织中核酸的FTIR光谱分析

在物理因素和化学因素的影响下 ,乳腺组织中DNA分子结构发生改变而出现损伤 ,导致碱基结构的诱发变异。研究表明 ,FTIR光谱能够灵敏地反应这种结构变化。通过比较不同类型乳腺疾病组织的FTIR光谱、去卷积光谱和数据分析 ,可以看出正常组织、良性组织以及癌组织在蛋白质、核酸和糖含量方面的差异。通过对不同类型乳腺组织中核酸的提取 ,经FTIR光谱和去卷积光谱分析 ,进一步研究了核酸中碱基结构和含量 ,磷酸盐结构和含量之间的差异。结果表明 :癌变组织中胶原蛋白和核酸含量有明显增加 ,糖蛋白含量逐渐减少 (除粘液癌外 )。提取核酸后的光谱和光谱数据显示 :癌变组织中碱基环鸟嘌呤的氢键化程度增强 ;在自由基·OH攻击下 ,癌组织中碱基环腺嘌呤大多数是以氧化的 8 OH Ade形式而存在 ,由于CN振动增强 ,峰位移向高波数 ,磷酸盐含量增加 ,去卷积后 ,A1 0 80 A1 0 50 数据显示 ,从正常、良性到癌组织 ,PO-2 相对于C—O含量增大。从分子生物学、分子医学角度 ,为研究癌变机理提供重要依据     

脉搏波系统的力学模型及反演兼对若干中医学问题的讨论

对脉搏波进行客观化定量研究,是我们面临的跨中医与西医、跨医学与数理学科的新挑战,是中国传统医学现代化发展的重点研究课题之一.本文遵循中医整体观点的传统思路,把脉搏波系统理解为生命能量以波的形式在血液中传播的整个系统,从连续介质力学的波动理论出发,为脉搏波系统建立一个等价的力学模型,并把力学反演方法推广发展到脉搏波.指出脉搏波是压力波P（X,t）,质点速度波v（X,t）、比容波V（X,t）和内能波E（X,t）这些不同形式波动的总成.脉搏现象包含着血液的流动和在血液中以远快于血液流速之波速传播的携带能量的脉搏波.前者是人眼易见的实体血液的“物质流”,而后者是人眼不易见、以波的形式传播的“能量流”,可分别理解为中医的“血”和“气”.脉搏波的传播特性由反映生命体整体系统的本构方程决定,就其重要性和地位而言,系统本构方程与中医的体质相当,应探索其内在联系.初步讨论了脉搏波系统本构关系非线性效应和黏性效应对脉搏波特性的影响.      

Nanoscale Distribution of Sulfonic Acid Groups Determines Structure and Binding of Water in Nafion Membranes

The connection between the nanoscale structure of two chemically equivalent, yet morphologically distinct Nafion fuel‐cell membranes and their macroscopic chemical properties is demonstrated. Quantification of the chemical interactions between water and Nafion reveals that extruded membranes have smaller water channels with a reduced sulfonic acid head group density compared to dispersion‐cast membranes. As a result, a disproportionally large amount of non‐bulk water molecules exists in extruded membranes, which also exhibit larger proton conductivity and larger water mobility compared to cast membranes. The differences in the physicochemical properties of the membranes, that is, the chemical constitution of the water channels and the local water structure, and the accompanying differences in macroscopic water and proton transport suggest that the chemistry of nanoscale channels is an important, yet largely overlooked parameter that influences the functionality of fuel‐cell membranes.