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511.
2-Aminothiazole and 2-iminothiazolidine derivatives were synthesized from the reaction of phenacyl bromide, thiourea, and its derivatives in aqueous media catalyzed by diammonium hydrogen phosphate (10%) and DABCO (10%) at room temperature in an efficient and simple procedure. 相似文献
512.
Thiourea‐bridged peracetylated glycoside calixarenes have been smoothly synthesized by the addition reactions of tetraacetylglycosyl isothiocyanates with amidoamine derivatives of calix[4]resorcinarene and p‐tert‐butylcalix[n]arenas (n=6, 8) in high yields (40–75%). All the glycoside‐containing calixarenes were characterized by 1H NMR, IR spectroscopy, and elemental analysis. 相似文献
513.
E. Contreras Aguilar G. A. Echeverría O. E. Piro S. E. Ulic M. E. Tuttolomondo 《Molecular physics》2018,116(3):399-413
A detailed structural and spectroscopic study of a new thiourea derivative 1-butyl-3-(1-naphthoyl)thiourea (1) is presented with the assistance of theoretical calculations. The X-ray diffraction structure analysis reveals a planar carbonylthiourea group, favoured by intra-molecular NH···O bond. The compound is arranged in the lattice as NH···O and NH···S bonded polymeric ribbons, that extend along the crystal b-axis. Molecular pairs involving N–H···S hydrogen bonds are a dominant contribution to packing stabilisation coming from coulombic component. Hirshfeld surfaces and two-dimensional-fingerprint plots show different intermolecular contacts and its relative contributions to total surface in each compound. The AIM approach shows the nature and strength of the strong and weak intramolecular interactions and the solvent effect, while NBO analysis reveals that the sulphur atom is responsible for the higher hyperconjugative stabilising energy. 相似文献
514.
硫脲解脱流程作为金矿样品金分析测试重要的前处理环节,在采用传统的水浴锅解脱流程测试过程中,发现存在耗电量大、比色管易进水汽、易结垢、架易腐蚀掉落等缺点。为了改善上述问题,本实验室在金分析过程中对解脱流程尝试做了改进,更换常用的水浴锅为恒温烘箱进行解脱,进而做了对比。同时,本研究对烘箱参数、温度设置、加热时间等做了对比分析,以获得最佳处理物理环境,并对改进前后所获得的测试结果进行了相关性分析,以判别其测试结果的可替代性。结果表明:采用烘箱代替水浴锅解脱,具有升温快,温度可控,耗电低,效率高,安全卫生,质量稳定可靠等优势。烘箱参数推荐设置为P:28、I:200、D:50,烘箱解脱过程中温度应控制95-102℃之间,升温时间15 min之后解脱液即可达到90 ℃以上,解脱时间一般需要35-40 min。通过相关性分析,其相关性系数均在0.99以上,呈近函数高度相关关系,由此认为,在实验室金分析过程中,烘箱代替水浴锅解脱完全可行,烘箱解脱更具有优势,应推广应用。 相似文献
515.
Galina F. Makhaeva Nadezhda V. Kovaleva Natalia P. Boltneva Elena V. Rudakova Sofya V. Lushchekina Tatiana Yu. Astakhova Igor V. Serkov Alexey N. Proshin Eugene V. Radchenko Vladimir A. Palyulin Jan Korabecny Ondrej Soukup Sergey O. Bachurin Rudy J. Richardson 《Molecules (Basel, Switzerland)》2022,27(3)
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-alkylene (5) —as potential multifunctional agents for the treatment of Alzheimer’s disease (AD). All compounds exhibited high inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with selectivity for BChE. These new agents displayed negligible carboxylesterase inhibition, suggesting a probable lack of untoward drug–drug interactions arising from hydrolytic biotransformation. Compounds 3 with bis-N-acyl-alkylene spacers were more potent inhibitors of both cholinesterases compared to compounds 5 and the parent amiridine. The lead compounds 3a–c exhibited an IC50(AChE) = 2.9–1.4 µM, IC50(BChE) = 0.13–0.067 µM, and 14–18% propidium displacement at 20 μM. Kinetic studies of compounds 3a and 5d indicated mixed-type reversible inhibition. Molecular docking revealed favorable poses in both catalytic and peripheral AChE sites. Propidium displacement from the peripheral site by the hybrids suggests their potential to hinder AChE-assisted Aβ42 aggregation. Conjugates 3 had no effect on Aβ42 self-aggregation, whereas compounds 5c–e (m = 4, 5, 6) showed mild (13–17%) inhibition. The greatest difference between conjugates 3 and 5 was their antioxidant activity. Bis-amiridines 3 with N-acylalkylene spacers were nearly inactive in ABTS and FRAP tests, whereas compounds 5 with thiourea in the spacers demonstrated high antioxidant activity, especially in the ABTS test (TEAC = 1.2–2.1), in agreement with their significantly lower HOMO-LUMO gap values. Calculated ADMET parameters for all conjugates predicted favorable blood–brain barrier permeability and intestinal absorption, as well as a low propensity for cardiac toxicity. Thus, it was possible to obtain amiridine derivatives whose potencies against AChE and BChE equaled (5) or exceeded (3) that of the parent compound, amiridine. Overall, based on their expanded and balanced pharmacological profiles, conjugates 5c–e appear promising for future optimization and development as multitarget anti-AD agents. 相似文献
516.
517.
Growth kinetics of zinc (tris) thiourea sulphate (ZTS) crystals investigated as a function of supersaturation is reported in this communication. Crystal growth rates were investigated normal to the (100), (010) and (001) faces under growth conditions employed for bulk crystal growth. The growth rates normal to (010) and (100) were found to follow the continuous growth model (RG = Cσ) with respect to the supersaturation whereas the growth rates normal to (001) was found to satisfy birth and spread (B+S) model (RG = Aσ5/6 exp(‐B/σ)). The growth rates observed normal to the studied face are in agreement with the growth mechanism predicted from the estimated α (Jackson) factor. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
518.
519.
Lucía Otero Julio Benítez Dinorah Gambino Eduardo Kremer Enrique
J. Baran Alvaro Mombrú Leopoldo Suescun Raúl Mariezcurrena 《无机化学与普通化学杂志》1999,625(11):1866-1872
Capability of [ReIII(tu-S)6]Cl3, where tu = thiourea, as a precursor to other ReIII complexes by ligand substitution in aqueous medium is studied. For the decomposition of [Re(tu-S)6]Cl3, experiments suggest pseudo first order kinetics and observed rate constants vary from 1.3 × 10–2 to 9.6 × 10–2 min–1 in the pH range 2.80–5.04. Experiments in presence of incoming ligand (ethylendiaminetetraacetic acid or diethylentriaminepentaacetic acid) show that ligand substitution is significantly slower than decomposition of the precursor, even when pH and temperature are modified. Similar results were obtained working with [ReIII(Metu-S)6]Cl3, where Metu = N-methylthiourea. Molecular structure of [ReIII(Metu-S)6](PF6)3 · H2O was determined by single crystal X-ray diffractometry. The coordination polyhedron around the Re ion is a distorted octahedron. The six methylthiourea ligands are bonded to the metal through the sulfur atoms [bond lengths range from 2.409(2) to 2.451(2) Å]. 相似文献
520.
《Mendeleev Communications》2023,33(3):362-364
A new polymer-analogous transformations of poly(N-vinylpyrrolidone) was used to prepare new complex-forming macromolecular systems containing thiourea and thio-semicarbazone sites. Two variants of modification were realized, namely, the method including the preliminary in situ activation of nucleophilic centres of the polymer amide fragments with dimethyl sulfate followed by introducing nucleophilic agents into the system, and the method including partial hydrolysis of poly(N-vinylpyrrolidone) followed by the amide coupling. The obtained modified polymeric materials react with silver ions in aqueous solution. 相似文献