4(6)-{2-[4-(2,3,4-三甲氧基苄基)哌嗪-1-基]-2-氧代乙氧基}芳甲酰胍类化合物的合成及其Na~+/H~+交换器1抑制活性

NHE1(Na+/H+交换器1)抑制剂对于心肌缺血再灌注损伤具有较好的保护作用.以苯(或吡啶)甲酰胍为母核,利用拼合原理,在苯(或吡啶)甲酰胍母环上引入4-(2,3,4-三甲氧基苄基)哌嗪-1-甲基,设计并合成了8个未见文献报道的目标化合物.其结构经MS,IR,1H NMR和元素分析确证.体外血小板肿胀模型(PSA)试验结果表明,大部分目标化合物显示出较好的NHE1抑制活性.     

A selective fluorescent turn-on NIR probe for cysteine

A selective and sensitive turn-on fluorescent NIR probe for cysteine has been developed. Cleavage of 2,4-dinitrobenzenesulfonyl (DNBS) with thiols switches the weakly fluorescent aza-BODIPY dye (λ(em) = 734 nm, Φ(f) = 0.03) to a strongly fluorescent species in the NIR region (λ(em) = 755 nm, Φ(f) = 0.14).     

Parametric studies on relationships between flutter derivatives of slender bridge (Ⅱ)

Based on curve fitting of coefficients of three component forces of the Messina Straits Bridge, and the previously proposed semi-analytical expressions of flutter deriva-tives of flexible structure, the change of flutter derivatives of slender bridge cross-section with respect to its aerodynamic center, rotational speed and angle variation is studied using a parametric method. The calculated results are compared with the measured ones, and expressions of flutter derivatives of the Messina Straits Bridge are derived. The in-trinsic relationships existing in flutter derivatives are validated again. It is shown that the influence of the rotational speed on flutter derivatives is not negligible. Therefore, it provides an additional semi-analytical approach for analyzing flutter derivatives of the bridge with streamlined cross-section to get its aerodynamic information.     

蛋白质高效分离两维色谱柱的选择优化

为了构建高效的离子交换/反相二维液相色谱(IEC/RPLC)分离平台系统,提高复杂蛋白质样品的分离效率,对色谱柱进行了评价与筛选。通过对实际人肝蛋白质样品的分离效果的比较,选择确定了TSKgel DEAE-5PW弱阴离子交换色谱柱(WAX)作为第一维色谱分离柱;考察了同一规格的10支代表性反相色谱柱(250 mm×4.6 mm, 5 μm, 30 nm, C4、C8或C18),通过评价其对尿嘧啶、硝基苯、萘和芴的分离性能以及对3种标准蛋白质样品的非特异性吸附、对人肝蛋白质样品的WAX馏分的分离效果,最终确定以Jupiter 300 C4反相色谱柱作为第二维色谱分离柱。对两维色谱柱的选择优化为蛋白质高效分离二维液相色谱平台的搭建提供了可靠基础。     

粉状工业炸药配方设计的数学模型

论述了含C、H、O、N、Al元素的工业炸药配方设计数学模型的建构方法 ,研究了无梯硝铵炸药、铵梯油炸药和含铝铵梯油炸药配方设计及最优化的数学模型 ,给出了上述几种粉状工业炸药配方设计及最优化数学模型的计算结果。对用理论配方所制工业炸药的爆炸性能也进行了研究 ,以证实数学模型的可靠性。     

大学物理虚拟实验的网络教学系统

介绍了基于当前Internet网络环境实现仿真实验远程教学的方案和技术,为各种实验的远程教学开发与应用提供了一种可行的新模式。     

生物制药研究中的多维色谱

对全二维气相色谱(GC×GC)、全二维液相色谱(HPLC×HPLC)、多维毛细管电泳等多维分离技术在生物制药研究中的应用进行了综述,其中对作者所在研究组在全二维气相色谱应用于中药及固相萃取-液相色谱联用分析系统等方面的工作做了重点介绍。由所综述的生物制药研究得出结论：多维分离方法以其高分辨、快速、自动化等特点已经在生物制药领域显示出它的巨大优势,并将发挥更大的作用。     

合肥储存环相干谐波自由电子激光研究方法的改进

 根据简单的计算模型,导出辐射能量谱形状因子和相干谐波辐射表达式,用此表达式讨论了不对称光学速调管的相干谐波辐射;对于合肥储存环相干谐波自由电子激光,提出了一个不对称光学速调管相干谐波辐射的研究方案,并且作了详细的计算,结果表明在较高的电子束能量下,调整光学速调管和外激光参数,使辐射段波荡器的辐射基波与外激光的二次谐波共振,进行相干谐波产生实验,能获得10⁹量级相干加强因子。     

台阶板中兰姆波A0模式传播特性的光弹研究

为了研究变壁厚结构中兰姆波的传播特性，以K9玻璃制成的台阶板为波导，运用动态光弹法实现了兰姆波在阶梯板中传播过程的可视化。使用MATLAB对兰姆波的理论应力分布进行了仿真，将仿真结果与光弹图像相对比以进行模式识别。此外，根据兰姆波的动态光弹图像计算了特定模式的相速度，并与相速度频散曲线相对比，以支持模式识别的结果。对4mm-3mm和4mm-2mm厚度差台阶板进行了对比分析。研究发现在激励目标模式的兰姆波时，可能会出现非目标模式，并且兰姆波的模态转换与频散程度与台阶处的厚度差有关。本文的结果可对具有相同性质类似结构材料的无损检测提供参考。     

Intelligent optimization of multi-column system of chromatography

To solve problems of the analysis of very complex mixtures, a multi-column system can be used. This needs a multi-column switching system or selectivity tuning for serially connected columns and is very difficulty to operate, therefore being unsuitable for standardization. Therefore, an intelligent optimization method for the multi-column system has been developed based on experimental data and the reliability of analytic results. As main results, optimization rules of column selectivity matching have been gained from experimental facts. The adaption of the multi-column system for different samples has been discussed and a method for comparison of column selectivities is presented. Practical analytic results using the multi-column system are demonstrated to verify the procedure.Dedicated to Professor Dr. Dr. h.c. mult. J. F. K. Huber on the occasion of his 70th birthday