Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents

A series of Andro derivatives were described and evaluated for their anti-HIV activity in vitro.Compound 10 and 16b,of which TI were>10,had some anti-HTV-l activity in vitro.Therein,compound 10 which was the best potent compound,could serve as a new lead for further development of anti-AIDS agents.     

Empirical likelihood hypothesis test on mean with inequality constraints

Hypothesis test on the population mean with various inequality constraints is studied in this paper.The empirical likelihood method is applied to construct test statistics.Limiting distributions of the empirical likelihood ratio test statistics are proven to be a weighted mixture of chi-square distributions.Numerical results are presented to show the validity of the proposed method.     

活体植物中β-胡萝卜素分子的二级拉曼散射谱

利用显微拉曼光谱技术对从法国梧桐树新鲜采集得到的树叶做了测试分析，在可见光514.5nm激发下，不对样品做任何提纯，直接得到了树叶中β－胡萝卜素分子的一级和二级拉曼光谱。根据对β－胡萝卜素分子拉曼散射位于2000－3100cm^-1之间和2000cm^-1以下谱线的仔细分析对比，得到了二级拉曼谱和一级谱的倍频、和频关系。实验研究表明，控制样品表面的激光强度和信号积分时间，不破坏活体树叶中的分子结构和构象，这为研究植物在不同的环境生长状况提供一种实时实地测量技术。此外讨论了用共焦显微拉曼研究活体植物的优点及限制。     

Lumped kinetic model for degradation of chitosan by hydrodynamic cavitation

The lumped kinetic model for the degradation reactions of chitosan by hydrodynamic cavitation was investigated in this study. The molecular weight distributions and mass concentrations were determined by gel permeation chromatograph (GPC). The degradation products were divided into several lumps according to their molecular weights. The appropriate number of lumps for the kinetic study was determined by comparing the residual sum of squares (RSS) values among different models. The RSS of six-lumped model (5.36 × 10^?3) was relatively small and the estimation of parameters was simpler than other models. In this paper, six-lumped kinetic model was adopted and the corresponding reaction network was established. The kinetic parameters were estimated with the Levenberg-Marquardt, and the results showed that the degradation reaction of chitosan was mainly dominated by the formation of degradation products with similar molecular weights. The maximum value of kinetic parameters on the diagonal of the reaction network (1.63 × 10^?1) was much larger than that of non-diagonal kinetic parameters (3.78 × 10^?2). According to the results calculated and measured under different conditions, this model could accurately predict the concentration distributions of lumps in the reaction network, and most of the average absolute deviation were smaller than 9.3%.     

Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity

A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the basis of spectral evidences,its structure was established and named as 4,5-didemethylpodophyllotoxin 7’-O-β-D-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines(Hela,K562,SH-SY5Y and CNE) in vitro.     

裂解气相色谱-质谱法对黄芩浸膏热裂解产物分析

采用热失重分析法(TGA)和在线热裂解气相色谱-质谱法(Py-GC-MS)研究了黄芩浸膏热裂解性质。在氦气氛围中,将黄芩浸膏分别在300,450,600,750,900℃下进行热裂解,并以气相色谱-质谱法对其裂解产物进行定性和半定量分析,并用黄芩浸膏进行了卷烟加香试验。结果表明:①在热失重曲线图中不能较明显地看出黄芩浸膏的较大失重点;②黄芩浸膏在上述温度下检测到的主要挥发性热裂解产物分别为12,18,28,42,40种;③600℃以下,黄芩浸膏热裂解产物主要是醛类、酮类、酯类和呋喃类物质;有害物质的量随着温度的升高而提高;900℃时,则主要为苯、甲苯、萘等有害成分;④黄芩浸膏具有提高卷烟香气质量、改善余味、柔和烟气的作用。     

应用壳聚糖-分子筛复合材料选择性吸附卷烟烟气中低分子醛酮

制备了3种壳聚糖-分子筛复合材料,并使用扫描电镜和ASAP 2020全自动吸附仪观测了复合材料的微观形态及其物理性质。对分别添加3种壳聚糖-分子筛复合材料、分子筛及壳聚糖的卷烟复合滤咀对主流烟气中低分子醛酮类化合物和其它有害物质(如焦油、尼古丁及一氧化碳等)的吸附效果进行了试验。结果表明:添加了壳聚糖-分子筛复合材料、分子筛及壳聚糖的卷烟滤咀对主流烟气中低分子醛酮类化合物均有较好的吸附作用,对焦油、烟碱量无明显影响;3种壳聚糖-分子筛复合材料对主流烟气中醛酮类化合物的吸附能力均优于其两种单体材料,该复合材料对一氧化碳有一定的吸附,且对抽吸品质有所改善,口感柔和,烟气刺激性降低。     

Minor antifungal aromatic glycosides from the roots of Gentiana rigescens （Gentianaceae）

Two new phenolic glycosides,2,3-dihydroxybenzoic acid methyl ester 3-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside(1) and 2,5-dihydroxylbenzofuran 5-O-β-D-xylopyranosyl-(1-6)-O-β-D-glucopyranoside(2),were isolated as the minor chemical constituents from the roots of Gentiana rigescens,along with 15 known compounds.Their structures were elucidated by detailed spectroscopic analysis,including 1D,2D NMR and chemical method.All of these compounds were isolated for the first time from the title plant.Moreove...     

基于多信号流图模型的导弹系统级故障诊断技术研究

为了实现对导弹装备系统级故障的诊断,提出了基于多信号流图模型的导弹故障诊断方法;该方法利用多信号流图模型建立系统的层次结构模型,在对导弹系统级测试性指标进行分析的同时,生成故障模式-测试相关性矩阵;在导弹测试出现故障时,利用故障模式与测试的相关性对相关性矩阵进行化简后,可将故障定位到具体LRU;最后,利用某型导弹电气系统对该方法进行了验证,试验结果证明,该方法对于导弹系统级的测试性建模与分析是有效的,利用该模型能够对导弹系统级故障进行准确定位。