溶液中芳香单酮的聚集态

本文对九种芳香单酮(苯乙酮、对氯苯乙酮、对甲氧基苯乙酮、对氨基苯乙酮、对硝基苯乙酮、间硝基苯乙酮、2.4-二甲基苯乙酮、1-萘乙酮和1-萘基苯基甲酮)在丙酮溶液中的吸收光谱进行了比较。发现芳香单酮在溶液中的分散是不均匀的, 随浓度增加, 有芳香单酮的聚集体生成。且芳香单酮分子的共轭体系越发达或苯环上电子云密度越犬, 分子就越易聚集。同时提出芳香单酮聚粲时的分子排列是苯环对苯环“面对面”取向的推断。     

2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors

Inhibition of the glycolytic pathway is a critical strategy in anticancer therapy because of the role of aerobic glycolysis in cancer cells. The glycolytic inhibitor 2-Deoxy-d-glucose (2-DG) has shown potential in combination with other anticancer agents. Buforin IIb is an effective antimicrobial peptide (AMP) with broad-spectrum anticancer activity and selectivity. The efficacy of combination treatment with 2-DG and buforin IIb in prostate cancer remains unknown. Here, we tested the efficacy of buforin IIb as a mitochondria-targeting AMP in the androgen-independent human prostate cancer cell line DU145. Combining 2-DG with buforin IIb had a synergistic toxic effect on DU145 cells and mouse xenograft tumors. Combination treatment with 2-DG and buforin IIb caused stronger proliferation inhibition, greater G1 cell cycle arrest, and higher apoptosis than either treatment alone. Combination treatment dramatically decreased L-lactate production and intracellular ATP levels, indicating severe inhibition of glycolysis and ATP production. Flow cytometry and confocal laser scanning microscopy results indicate that 2-DG may increase buforin IIb uptake by DU145 cells, thereby increasing the mitochondria-targeting capacity of buforin IIb. This may partly explain the effect of combination treatment on enhancing buforin IIb-induced apoptosis. Consistently, 2-DG increased mitochondrial dysfunction and upregulated Bax/Bcl-2, promoting cytochrome c release to initiate procaspase 3 cleavage induced by buforin IIb. These results suggest that 2-DG sensitizes prostate cancer DU145 cells to buforin IIb. Moreover, combination treatment caused minimal hemolysis and cytotoxicity to normal WPMY-1 cells. Collectively, the current study demonstrates that dual targeting of glycolysis and mitochondria by 2-DG and buforin IIb may be an effective anticancer strategy for the treatment of some advanced prostate cancer.     

Speciation analysis of aluminium(III) in natural waters and biological fluids by complexing with various catechols followed by differential pulse voltammetry detection

The biological effects of aluminium have received much attention in recent years. Speciation of Al is of basic relevance as it concerns its reactivity and bioavailability. A differential pulse voltammetry (DPV) procedure is proposed for speciation analysis of Al(III) in natural waters and biological fluids using six catechols (L-dopa, dopamine, epinephrine, norepinephrine, caffeic acid and o-benzenediol) as electroactive ligands. The decrease of the DPV anodic peak current for each catechol ligand is linear with the increase of Al concentration. This speciation analysis idea is based on the measurement of the complexation capacity, namely, different affinities of Al(III) for catechols and organic ligands under two pH conditions. The labile monomeric Al fraction (mainly inorganic aluminium) is determined at pH 4.6, while the total monomeric Al fraction is determined at pH 8.5. The principle for Al(III) speciation analysis by an electrochemical method is discussed. This sensitive and simple fractionation method is successfully applied to the speciation analysis of Al in natural waters and the results agree well with those of Driscoll's method. The speciation analysis of Al in biological fluids is also explored and the results are compared with those obtained by ultrafiltration and dialysis. Compared with other speciation protocols the electrochemical method possesses some remarkable advantages: rapidity, high sensitivity, cheap instrumentation and a simple operation procedure.     

Dithia-crown-annelated tetrathiafulvalene disulfides: synthesis, electrochemistry, self-assembled films, and metal ion recognition

The synthesis and electrochemistry of a series of tetrathiafulvalene (TTF) and dithia-crown-TTF derivatives attached with one or two disulfide group(s) 7a-f are reported. The self-assembled monolayers (SAMs) of these TTF disulfides on gold were prepared and characterized by reflection-absorption infrared spectroscopy. The SAMs are extremely stable under a wide variety of conditions and over extended periods of time and show remarkable electrochemical stability upon repeated potential scans. SAMs of the crown-TTF disulfides 7c,d,f can recognize alkali metal ions, and the process can be monitored following the electrochemical potential shift of the surface-confined TTF group.     

希土盐与三种α-氨基酸配合物的合成和化学键性质的研究

合成了１４种希土氨基酸的固态配合物，并用反射电子光谱对其进行了表征。根据电子反射光谱数据，对每个配合物的Ｓｌａｔｅｒ－Ｃｏｎｄｏｎ参量（Ｆ２、Ｆ４、Ｆ６）和Ｌａｎｄｅ参量（ζ４５）、Ｎｅｐｈａｌａｎｘｅｔｅ比率（β）进行了计算，还计算了平均共价参数（δ）、成键参数（ｂ１／２）及Ｓｌａｔｅｒ径向积分比值（Ｆ４／Ｆ２与Ｆ６／Ｆ２）。结果表明：在这些配合物中ＲＥ３＋与三种α－氨基酸间配位键存在一定程度的共价性     

高效石墨浮选剂的合成

高效石墨浮选剂的合成金婵，薛玉，汪进，刘欣荣，秦英海（哈尔滨工业大学应用化学系哈尔滨１５０００１）（大庆石化总公司大庆）关键词石墨，浮选剂，合成，混合烃由于石墨具有良好的力学性能、导电、高熔点等性质，广泛用于原子能、宇航和民用工业。隐晶质石墨属于微晶...     

Solid state synthesis and structure of two novel polyoxometalates [(n-Bu)4N]4[M6O19][Ag2I4](M?Mo,W)†

The reaction of [NH₄]₂[MO₂S₂], AgI and (n-Bu)₄NBr in solid state produced the polyoxometalates [(n-Bu)₄N]₄[M₆O₁₉][Ag₂I₄] (1, M? Mo; 2, M? W) which were structurally determined. The crystals of 1 and 2 are isomorphous, monoclinic, space group P2₁/c. 1, a = l.6624(2), b=1.6699(3), c=l.7217(2) nm, β=98.29(1)°, V=4.729(1) nm³, Z=2, R=0.040, R_w“0.037; 2, a = 1.6636(3), b = 1.6733(3), c = 1.7190(3) nm, β=98.25(1)°, V=4.736(l) nm³, Z = 2, R = 0.038, R_w = 0.047. The results of the structure determination showed that the two compounds had the same structures whose skeletons are composed of [Ag₂I₄]². and [M₆O₁₉]^2-. The difference of them and heteropolymetalate compounds synthesized in solution is that the title compounds contain cluster. ion, heteropolymetalate and organic cations, while the latter is only composed of heteropolymetalate and organic cations.     

Reactions of Tris(acetonitrile)tricarbonylchromium with Trimethylsilylarenes

The reactions of tris(acetonitrile)tricarbonylchromium 1 with trimethylsilyl derivatives 2–5 of phenalene, indene, 1,2-dihydronaphthalene and trans-β-methylstyrene gave products 10-13, respectively, containing no trimethylsilyl groups. The reactions of 1 with trimethylsilyl derivatives 6–8 of benzene, toluene and cycloheptatriene gave products 14–16, respectively, containing trimethylsilyl groups. The reaction of 1 with 1,2-bis(trimethylsily-1,2-dihydro)naphthalene 9 gave product 17 in which only trimethylsilyl at the allylic position was cleaved. Compound 10 crystallizes in the orthorhombic system, space group Pbca, with a = 12.228(4), b = 14.288(1), c = 15.128(3) Å, Z = 8, R_F= 0.046, and R_w = 0.047. X-ray crystallographic data confirm that the Cr(CO)₃ moiety is bonded to phenalene in a η⁶-mold.     

氧化共沉淀法制备纳米级掺锑α—Fe2O3气敏陶瓷粉料

氧化共沉淀法制备纳米级掺锑α┐Ｆｅ２Ｏ３气敏陶瓷粉料王忠春＊＊刘尔生陈耐生＊黄金陵（福州大学化学系福州３５０００２）关键词α－Ｆｅ２Ｏ３陶瓷，锑掺杂气敏材料，纳米材料１９９６－１０－０５收稿，１９９７－０４－２２修回福建省科委资助项目＊＊现在上海硅酸...     

合成多肽的电喷雾质谱研究

利用电喷雾多极串联质谱对3种合成多肽进行了系统的鉴定和分析研究。首先通过全扫描模式测定了其分子量，然后选择[M H]^ 或[M 2H]^2 离子通过串联质谱(MS／MS)得到碎片离子，采用y离子和b离子互补的方法测定了多肽序列。利用文献数据对这种方法进行了验证，实验结果表明，该方法简便、快速、实用。