表面活性剂类多肽A6KA6K的自组装及机理研究

为了研究表面活性剂类多肽疏水链段长度及亲疏水氨基酸比例对其自组装结构的影响,本文设计了一种表面活性剂类多肽A6K的二倍体A6KA6K。圆二色谱分析表明的二级结构主要为无规卷曲结构并伴有少量的α-螺旋;透射电子显微镜和动态光散射分析表明,其在水溶液中能自组装形成纳米囊泡状结构。芘荧光分子探针研究表明自组装体存在疏水微区域将芘分子包裹在其中,证明了这种多肽在溶液中可形成胶束类的自组装体,并计算了其临界胶束浓度。相比已报道的表面活性剂类肽A6K,本文设计的肽序列A6KA6K由于在较长疏水链段区域中存在亲水性氨基酸K,对疏水相互作用有影响,使得含有14个氨基酸的肽自组装形成纳米囊泡状结构。     

(2S,4S)-苯甲基-2-(6-氟-1H-吲哚-3-羰基)-4-羟基-吡咯烷-1-羧酸酯的合成

以4-羟基-L-脯氨酸为原料,经Cbz保护、偶联、Mitsunobu反应和水解合成了抗肿瘤新药Birinapant的重要中间体--(2S,4S)-苯甲基-2-(6-氟-1H-吲哚-3-羰基)-4-羟基吡咯烷-1-羧酸酯,总收率83%,其结构经¹H NMR和ESI-MS确证。     

带次线性中立项的二阶广义Emden-Fowler微分方程的Philos型振动准则

研究一类带次线性中立项的二阶非线性广义Emden-Fowler时滞微分方程的振动性.利用Riccati变换和不等式技巧,在非正则条件下建立了该类方程多个简便的Philos型和Kamenev型新振动准则.所得定理也适应于包括经典Euler方程等线性非中立型方程,推广和改进了已有文献中的相应结果.最后还给出应用实例展示了所得定理是有效和便捷的.     

基于联萘酚的水溶性手性大环荧光传感器的合成与晶体结构

以R-联萘酚、氯氰胺、间苯二胺、1,2二苯基乙二胺、乙二胺为原料合成了3个水溶性手性大环荧光传感器;利用核磁共振(1 H NMR和13 C NMR)、质谱、红外光谱验证了合成产物的结构,利用元素分析仪测定了其组成,并利用X射线衍射分析确定了单晶R-3的晶体结构.结果表明,R-3属于单斜晶系,P2(1)/n空间群,晶胞参数为:a=1.128 6nm,b=1.566 1nm,c=2.293 9nm,β=90°,Z=4,Dc=1.328g.cm-3,F(000)=1 684.     

纳米银催化的鲁米诺化学发光体系测定呋喃硫胺的研究

基于纳米银能够增强鲁米诺-H2O2-呋喃硫胺体系化学发光的现象,建立了测定呋喃硫胺的流动注射化学发光新方法.对体系的化学发光机理进行了初步探讨,发现该体系的化学发光光谱的最大发射波长为425nm,该体系的发光体为激发态的3-氨基邻苯二甲酸根离子.该方法测定呋喃硫胺的线性范围为1.0×10-8～1.0×10-5g/mL,检出限4×10-9g/mL,对1.0×10-6g/mL呋喃硫胺连续9次测定的相对标准偏差(RSD)为1.9％.方法已用于药物呋喃硫胺片中呋喃硫胺的测定.     

非线性光学中薛定谔型方程的整体吸引子

研究了一类非线性薛定谔型方程,描述了光波在光折射晶体中的传播.首先构造了该模型整体弱的吸引子,然后通过能量方程的精确分析,证明整体弱吸引子实际为系统整体强吸引子.最后给出了整体吸引子的分形维数和Hausdorff维数的上界估计.     

关于拟连续domain以及函数空间的注记

用伴随的方式给出了拟连续domain以及其Scott闭集格(又叫广义完全分配格)的等价刻画。此外,本文证明了拟连续格关于函数空间是不封闭的,从而不能构成cartesian闭范畴。     

Numerical Simulation of Two-Dimensional Flow over Three Cylinders by LatticeBoltzmann Method

The numerical simulation using the multiple relaxation time lattice Boltzmann method (MRT-LBM) is carried out for the purpose of investigating the two-dimensional flow around three circular cylinders. Among these three circular cylinders, one of the three cylinders on which a forced in-line vibrating is used to do this research and attempt to find out the effects of the movingcylinder and the other two rigid cylinders on the wake characteristics and vortex formation. As a benchmark problem to discuss the problem of lift coefficient r.m.s for these cylinders with spacing ratios T/D between other rigid side-by-side cylinders, and the calculation is carried out with two compared cases at Reynolds number of 100, two of the cylinders are rigid and the other one is an in-line vibrated cylinder lying downstream, in addition, forced vibrating amplitude and frequency are A/D= 0.5 and f_ν=0.4 (where A is the forced amplitude, D is the cylinder diameter, and f_ν stands for the vibrating frequency, respectively). The calculated results not onlyindicate that the spacing ratios T/D (T is the center-to-center spacing between the two upstream cylinders) have influence on the wake patterns and the formation of vortex shedding, but also analyze the lift coefficient r.m.s for the three cylinders with the spacing ratios S/D (where S is the center-to-center spacing between the center of upstream two side-by-side cylinders and downstream cylinder).     

Study on the Synthesis and Biodegradation of Aliphatic Polyester

With the increasing use of one-off plastic products, the environmental pollution resulted from the plastic waste has become more and more serious. So many scientists have focused their attention on developing biodegradable polymers to substitute the traditional unbiodegradable polymers in the manufacture of disposable products. Thus the plastic waste can be treated by landfill or composting technique. It has been found that aliphatic polyesters possess better biodegradability compared with oth…     

蠕墨铸铁／40Cr配副干摩擦三维表面形貌特征研究

采用探针式三维表面形貌仪考察了销－盘式干磨擦试验条件下蠕墨铸铁度销磨损表面的三维形貌特征。结果表明：度销磨损表面主要呈现犁沟型、孤岛型及二者的混合型３种形貌特征,其中具有孤岛型磨损表面形貌特征的试样的摩擦系数较高,磨损率较低;而具有犁沟型磨损表面形貌特征的试样的摩擦系数最低,磨损率最高,分析表面形貌参数发现：犁沟型表面形貌具有最大的表面高度偏差和表面空隙率及高负值的表面高度分布参数;而孤岛型表面形貌的表面高度偏差和表面空隙率最小,表面高度分布参数为高正值。