A deterministic,multi-item inventory model with supplier selection and imperfect quality

This paper considers the scenario of supply chain with multiple products and multiple suppliers, all of which have limited capacity. We assume that received items from suppliers are not of perfect quality. Items of imperfect quality, not necessarily defective, could be used in another inventory situation. Imperfect items are sold as a single batch, prior to receiving the next shipment, at a discounted price. The demand over a finite planning horizon is known, and an optimal procurement strategy for this multi-period horizon is to be determined. Each of products can be sourced from a set of approved suppliers, a supplier-dependent transaction cost applies for each period in which an order is placed on a supplier. A product-dependent holding cost per period applies for each product in the inventory that is carried across a period in the planning horizon. Also a maximum storage space for the buyer in each period is considered. The decision maker, the buyer, needs to decide what products to order, in what quantities, with which suppliers, and in which periods. Finally, a genetic algorithm (GA) is used to solve the model.     

A predictive, simple and rapid method for thermodynamic study on the binding of copper ion with Alzheimer''s amyloid β peptide

The interaction of CuC12 to the first 16 residues of the Alzbeimer's amyliod β peptide, Aβ(1-16) was studied by isothermal titration calorimetry at pH 7.2 and 37 ℃ in aqueous solution.     

Recent strategies in the synthesis of thiophene derivatives: highlights from the 2012–2020 literature

Molecular Diversity - Thiophene-based analogs have been fascinated by a growing number of scientists as a potential class of biologically active compounds. Furthermore, they play a vital role for...     

The Ladder Operators on 1 + 1-de Sitter Space

International Journal of Theoretical Physics - In this paper, we present the annihilation and creation operators for a moving scalar massive particle on 1 + 1-de Sitter space. This presentation is...     

DNA Binding Studies and Cytotoxicity of Ethylenediamine 8‐Hydroxyquinolinato Palladium(II) Chloride

Interaction between ethylenediamine 8‐hydroxyquinolinato palladium(II) chloride and calf thymus DNA (CT‐DNA) in aqueous solution were studied by UV‐Visible absorption, fluorescence spectroscopic techniques and gel chromatography at temperatures of 300 K and 310 K. The complex bound strongly and intercalatively to the CT‐DNA. The results of the cytotoxicity assay of the Pd(II) complex on the leukemia cell line, K562 indicated lower cytotoxicity than cisplatin. The Pd(II) complex is considered an agent with potential antitumor activity. The calculation of several binding and thermodynamic parameters of the inclusion Pd(II) complex with CT‐DNA may provide deeper insights into the mechanism of action of these types of complexes with nucleic acids.     

Analytic approach to the approximate solution of the independent DGLAP evolution equations with respect to the hard-Pomeron behavior

We show that it is possible to use hard-Pomeron behavior to the gluon distribution and singlet structure function at low x. We derive a second-order independent differential equation for the gluon distribution and the singlet structure function. In this approach, both singlet quarks and gluons have the same high-energy behavior at small x. These equations are derived from the next-to-leading order DGLAP evolution equations. All results can be consistently described in the framework of perturbative QCD, which shows an increase of gluon distribution and singlet structure functions as x decreases.     

Multiple scattering of an obliquely incident plane acoustic wave from a grating of immersed cylindrical shells

The study of the interaction of acoustic waves with cylindrical structures has numerous applications including the ultrasonic nondestructive testing of materials. In this paper, using a new mathematical model presented for the scattering of obliquely incident plane acoustic waves from a grating of immersed cylindrical shells, a detailed study of the resonant interaction of A-wave resonances originating from the shells is conducted. The nature of A-wave resonances and the effect of center-to-center distance of the shells on these resonances are examined. It is observed that this resonant interaction not only results in the splitting of A-wave resonances, but also causes an increase in resonance amplitudes. This interaction phenomenon is not seen in Rayleigh, whispering gallery and guided wave resonances. It is also shown that increasing the angle of wave incidence to the grating weakens the A-wave resonant interactions. The numerical results obtained from the mathematical model are compared to experimental results available in the literature for gratings composed of two and three aluminum shells. The numerical results are in very good agreement with their experimental counterparts.     

Errorless and errorful learning modulated by transcranial direct current stimulation

Background

Caspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In contrast with the auditory system, details of the vestibular phenotype have not been characterized. Here we report the vestibular phenotype and inner ear anatomy in the caspase-3 deficient (Casp3 ^-/- ) mouse strain.

Results

Average ABR thresholds of Casp3 ^-/- mice were significantly elevated (P < 0.05) compared to Casp3 ^+/- mice and Casp3 ^+/+ mice at 3 months of age. In DPOAE testing, distortion product 2F1-F2 was significantly decreased (P < 0.05) in Casp3 ^-/- mice, whereas Casp3 ^+/- and Casp3 ^+/+ mice showed normal and comparable values to each other. Casp3 ^-/- mice were hyperactive and exhibited circling behavior when excited. In lateral canal VOR testing, Casp3 ^-/- mice had minimal response to any of the stimuli tested, whereas Casp3 ^+/- mice had an intermediate response compared to Casp3 ^+/+ mice. Inner ear anatomical and histological analysis revealed gross hypomorphism of the vestibular organs, in which the main site was the anterior semicircular canal. Hair cell numbers in the anterior- and lateral crista, and utricle were significantly smaller in Casp3 ^-/- mice whereas the Casp3 ^+/- and Casp3 ^+/+ mice had normal hair cell numbers.

Conclusions

These results indicate that caspase-3 is essential for correct functioning of the cochlea as well as normal development and function of the vestibule.     

Effects of external electric and magnetic fields on the linear and nonlinear intersubband optical properties of finite semi-parabolic quantum dots

In this work, influences of external electric and magnetic fields on the optical rectification coefficient, the linear and the third-order nonlinear optical absorption coefficients as well as refractive index changes of finite semi-parabolic quantum dots are investigated. In this regard, energy eigenvalues and eigenfunctions of the system are calculated numerically, and optical properties are obtained using the compact density matrix approach. The results show that external electric and magnetic fields have a great influence on these optical quantities.