吉林大学高分子学科:惟实励新 笃行致远

吉林大学高分子学科创建于1958年,是吉林大学化学学科的重要分支。在64年的学科发展中,一代代吉大高分子人惟实励新、砥砺奋进,建设了具有理工融合特色的高分子专业,培养了大批高分子科学领域的优秀人才。回顾了吉大高分子学科的发展历程,重点介绍了吉大高分子学科在课程建设、人才培养、科学研究等方面的成就进展。在吉大化学70周年华诞之际,谨以此文致敬那些为吉大高分子学科发展做出贡献的校友、同仁和朋友们。     

吉林大学分析化学学科:薪火相传 服务社会

2022年是吉林大学化学学科创建70周年,分析化学作为吉林大学化学学科的重要分支学科始建于1952年。回顾了吉林大学分析化学学科的历史沿革和发展成就。一代代吉大分析化学人始终秉承“献身、创新、求实、协作”的科学精神,为国家培养了一大批优秀人才。谨以此文,敬献给为吉林大学分析化学学科发展做出贡献的校友和朋友们。     

吉林大学无机化学学科:继往开来 砥砺前行

吉林大学无机化学学科创建于1952年,至今已有70年历史,几代吉大无机化学人踔厉奋发、笃行不怠,一直为建设世界一流学科而努力奋斗。回顾了吉大无机化学学科的历史沿革和奋斗历程,并着重介绍了吉大无机化学学科在教材建设、课程建设、科技创新和人才培养等4个方面的卓越成就。谨以此文,致敬那些为吉大无机化学学科发展做出贡献的前辈、同事和同学们。     

吉林大学物理化学一流课程的建设历程*

依托吉林大学化学学科发展,建设吉林大学物理化学一流课程,培养一流化学学科创新人才。主要简介吉林大学物理化学一流课程的建设,包括课程的发展经历;教学团队建设;课程特色和创新性;物理化学课程的教学改革;教材的建设;教学研究项目及发表教学文章;教学与科研相结合等。     

高等学校化学类外国教材研究成果交流会

受国家教委委托,于1990年9月6日—8日在吉林大学召开了高等学校化学类外国教材研究成果交流会。参加会议的有清华、复旦、南大、南开、吉大等13个单位,收到论文32篇。内容包括普通化学、无机、分析、有机、物理化学,还有环境化学、生物化学、有机地球化学、食品化学、高分子化学等专业学科;涉及美、英、苏、德、法、印度、挪威、日本等国化学教材。吉林大学外国教材中心作了题为“外国教材中心历史沿革、藏书建设与服务工作情况介绍”的大会发言。研究论文有对外国教材的介绍、评价,尤其侧重分析外国教材的先进性、科学性和继承性;有分析外国教材的编写特点;国内外教材的对比研究;介绍国外教材建设     

吉林大学应用化学学科:理工兼备 特色发展

吉林大学应用化学学科始建于1986年,依托吉林大学化学学科深厚理论基础与学术优势,经过几代应用化学学科人的不懈努力,逐渐形成了“理工兼备”的学科特色。在吉林大学化学学科70华诞之际,回顾了应用化学学科的发展历程,着重介绍了应用化学学科在本科教学与专业特色、科学研究与平台建设、人才培养与社会服务等3个方面取得的成绩,以及今后发展的设想。     

土壤胶体化学家虞宏正的学术思想与科学贡献

虞宏正是我国著名的胶体化学与物理化学家、教育家。他扎根西北,融汇世界思想,形成了颇具价值的学术思想,至今仍是当代科学研究的精髓与主导思想。他毕生致力于胶体化学、热力学研究,建立了新的分支学科,开创了土壤科学研究所,培育了几代化学科学家,为中国化学学科和农业科学的发展做出了重要的贡献。     

吉林大学化学学科物理化学课程的改革探索

以“基础学科拔尖学生培养试验计划”和人才培养基地的建设为背景,介绍了吉林大学在“拔尖计划”项目带动下,化学学院物理化学课程团队围绕教学理念、教学方法、考核方式方法、团队建设、教材建设及信息化建设等方面进行改革与建设中取得的经验与成果。以期为化学学科基础人才培养过程中基础课程体系的教学改革提供借鉴。     

优化物理化学学科资助布局，提升科学基金资助效能

本文总结了物理化学学科代码的设立和调整变化情况,结合近十年物理化学学科研究发展趋势,论述了自2018年物理化学学科代码优化调整为催化与表界面化学和化学理论与机制以来,优化学科布局对于促进学科前沿基础研究和提升科学基金资助效能方面起到了重要作用,提出了在优化学科布局方面的思考和建议,为后续学科发展战略提供参考。     

提高实验室安全管理水平 为学科人才培养保驾护航

化学是一门以实践为基础的学科,保障实验室安全是学科发展建设中的重要事项,是教学和科研正常有序进行的基本需求。以提升吉林大学化学学院实验室管理水平为目标,从制度体系、培训体系、保障体系、文化体系等方面在本科实验教学平台和科研平台开展的具体举措为例,探索出适合实际发展需求的实验室安全管理模式,为化学学科的建设与人才培养保驾护航。     

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Selective synthesis of 4,5-dihydroimidazo- and imidazo[1,5-a]quinoxalines via modified Pictet–Spengler reaction

An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a–g and imidazo[1,5-a]quinoxalines 7a–h by the reaction of 2-imidazolyl anilines 4a–c with aryl aldehydes 5a–k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a–b was found to be instrumental for the success of the reaction.     

Understanding the Diels-Alder reactivity of 1,2-azaborine analogues

The Diels-Alder reactivity of 1,2-heteroborines (H₄C₄B(H)X, X?=?NH, PH, AsH; O, S, Se) has been computationally explored by means of Density Functional Theory (DFT) calculations. The influence of the HB?=?X fragment on the reactivity of the system has been quantitatively analyzed in detail by means of the so-called Activation Strain Model (ASM) of reactivity. It is found that the interaction between these species and the dienophile is significantly stronger than that computed for their all-carbon isoelectronic counterpart, benzene. In addition, the strain energy plays a key role in the observed reactivity trends. The role of the aromaticity strength of these heteroarenes on the reactivity is also assessed.     

Synthesis of N-substituted carbazolones from α-iodo enaminones via Pd(0)-catalyzed intramolecular coupling under microwave irradiation

A variety of N-aryl and N-alkyl carbazolones were conveniently achieved in good to high yields via Pd₂(dba)₃-mediated intramolecular coupling of N-substituted α-iodo enaminones under microwave irradiation. The Pd(0)-catalyzed cyclization was found to proceed favorably with the more electron-deficient phenyl ring during the reactions involving unsymmetrical N,N-diaryl α-iodo enaminones. This unique property enables the construction of carbazolone skeleton containing nitro substituted benzenoid ring.     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition

Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles.