研究性高分子化学实验课程改革探索

首先论述了研究性高分子化学实验的重要性及其研究现状,根据现有研究的空白,结合具体的高分子化学实验《有机玻璃制备》,详细论述了研究性高分子化学实验各环节的设计、实施及其作用。根据本文可直接实施研究性《有机玻璃制备》实验,并可推广至其他高分子化学实验研究性方案的设计和实施。通过此研究性高分子化学实验课程的改革,不仅提高了学生的动手能力,而且提高了学生独立思考、发现问题的能力,强化了理论与实践的结合,深化理论知识的理解和吸收,综合训练了学生的科学研究能力。     

工科高分子专业的高分子化学与物理实验教学的几点体会

介绍了山东科技大学化学与环境工程学院,在工科高分子专业的高分子化学与物理课程教学中所进行的改革.一方面加强实验环节,在基本实验基础上,开设综合设计性实验,提高学生解决实际问题的动手能力,同时在第二课堂中开展学生课外科技活动,并积极挖掘第三课堂,开展社会实践,增强学生社会适应性,形成了以课堂为主,实验、综合设计、毕业设计和科研相结合的特色创新教育模式,突出了对学生科研、工程等综合能力的培养,取得了阶段性成果.     

高分子专业大综合实验课程的设置与实践

在高素质创新型人才培养目标的指导下,我们在高分子材料与工程专业的培养方案中新增了专业大综合实验课程。该课程模拟本科毕业论文的过程,以团队合作的形式进行,实验项目不仅综合性强,内容丰富,同时体现我院高分子方向的科研特色,实现了教研相长。在大综合实验课程的实践过程中,我们积极探索,努力激发学生的学习兴趣,培养他们的创新思维、创新毅力以及团队精神,拓宽他们的知识面,增强他们的实践创新能力,初步取得了良好的教学效果。     

基于专业认证的“高分子浆料浆纱工艺综合实验”课程教学改革

根据工程教育专业认证要求,分析"高分子浆料浆纱工艺综合实验"课程教学的现状及存在问题,基于专业认证视角,提出该实验课程改革的思路和方法。为更好地适应专业认证要求,增强学生解决复杂工程问题的能力,明确了该课程支撑的毕业要求和课程指标点,更新了教学大纲、实验设备,新增浆料制备,以及浆液、浆膜性能测试等实验教学环节,增加设计性、创新性实验项目比例,并更新了课程考核方式,在提高学生解决复杂工程问题能力的同时,实现课程内容的可持续改进。     

高分子材料专业贯通式实验案例教学探索

高分子材料专业的贯通式实验案例教学是将基础知识、探索性专业实验和工程化实践应用融汇贯通的新型教学模式。以高分子材料反应共混改性沥青加工试验为例,介绍了该教学模式的方法、步骤与特点。学生通过查阅文献、实验设计、动手操作、撰写论文及实体工程实践等环节,深化利用已学基础知识和专业知识,培养分析问题和解决问题能力。该贯通式实验案例教学有利于本科生、研究生尽快掌握高分子材料科学与工程的内涵,选择感兴趣的方向,快速进入毕业设计研究,了解社会需求和优化职业取向,加强专业体验性和理解能力。对培养学生综合素质,提高创新、创业能力有重要意义。     

功能高分子材料综合实验设计:荧光稀土液晶高分子防伪膜的制备

设计了一个综合性实验,将荧光稀土液晶高分子防伪膜的制备和现代分析测试技术应用于高分子专业的教学实验中,以提高学生的综合实践能力。实验包括荧光稀土液晶高分子的制备、表征、防伪性能评价3大部分。采用FTIR、荧光光谱仪、POM、XRD、TG表征荧光稀土液晶高分子的结构与性能;制备荧光稀土液晶高分子防伪膜对其防伪性能进行评价,给整个实验增添趣味性与实用性。通过开设该实验,可让学生了解功能高分子的前沿知识及现代分析测试技术的基本原理和用途,掌握专业的实验操作与数据处理方法,提高学生的综合实践能力和专业素质。学生实验证明该综合实验适用于本科实验教学。     

《高分子材料成型加工原理》课程教学方法探究

《高分子材料成型加工原理》是高分子材料与工程专业最重要的专业课程之一。但是仅凭课堂讲授很难让学生理解高分子材料加工工艺的过程及其原理,学生参与性差。针对学院的《高分子材料成型加工原理》课程特点,通过计算机在配方设计当中的应用、多媒体的应用、案例分析和学生互动交流相结合的教学方法加深学生对高分子材料加工过程及其原理等抽象概念的理解。授课方式既有理论讲解、又有实例演示,使课程教学更具实用性,激发学生的学习兴趣,培养学生分析问题、解决问题的能力,提高了高分子专业这门课程的教学效果。     

棉杆木质素提取及其对聚丙烯抗氧化性能分析的综合性实验

介绍了一个以从新疆废弃棉花秸秆中提取出的木质素为原料及其对聚丙烯(PP)抗氧化性能为一体,针对高分子相关专业开设的综合性实验。基于新疆大学高分子相关专业的实际情况,将教师的科研项目与本科教学相结合,该综合性实验主要包括了棉杆木质素的提取、人工加速老化试验和抗氧化性能表征分析的特色实验体系。在实践教学中,学生不仅学习了棉杆木质素的提取过程,还认识了人工加速老化试验对材料的老化机理及其对抗氧化性能的影响,也拓宽了对专业知识的综合理解,为科研成果转化为教学实验提供了借鉴。     

高分子材料专业《计算机在材料研究中的应用》课程教学改革与实践

为了适应行业发展的新趋势,众多高分子材料专业开设了《计算机在材料研究中的应用》这门特色专业课,其对提升学生利用计算机解决高分子材料中实际问题的能力起着重要的支撑作用。本文结合高分子材料的专业特点和多年来的教学改革实践,从课程体系的建设、教学内容的优化、多种教学手段的应用以及教学效果的评价等几个方面介绍了该课程的教学改革和课程建设的经验和体会,并对疫情期间多种线上教学手段在本课程中的应用效果进行了介绍,以期为相关院校的课程改革提供有益的借鉴。     

工程认证背景下高分子材料与工程专业实验教学的改革初探

基于专业认证视角,分析了高分子材料与工程专业实验教学的现状及存在问题,提出了改革实验实践课程的具体举措。遵循工程认证的三个核心理念(以学生为中心、产出导向、持续改进),聚焦学生解决复杂工程问题能力的培养,我校本专业对课程体系进行调整,构建了"链条式"实验课程体系,促进理论与实践的无缝对接;对实验课程实施过程性评价,建立了形成性评价与结果性评价并重的评价体系;通过提高综合性与探究性实验的比例,精心设计高分子综合实验,来提高学生解决复杂工程问题的能力。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.