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4-羟基-2,5-二甲基-3(2H)呋喃酮的合成 总被引:3,自引:0,他引:3
总结了食品增香剂4-羟基-2.5-二甲基-3(2H)呋喃国的合成方法,包括近期的合成研究进展,对一些合成方法的优缺点作了评述。参考文献28篇。 相似文献
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通过1-苯基-3-对甲苯磺酰基硫脲(1)与亚磷酸三苯酯和取代苯甲醛在甲苯中进行的类Mannich反应合成1-对甲苯磺酰基-2-氧代-2-苯氧基-3-芳基-1,4,2-二氮磷杂环戊-5-硫酮(2).本文对合成过程中所涉及到的副反应进行了初步探讨,初步的生物活性测定结果表明,化合物2具有一定的除草活性。 相似文献
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1-硫脲乙基-2-芳基-2-咪唑啉化合物的合成刘运廷,章荣玲(山东工业大学数理系济南,250014)关键词咪唑啉,硫脲基,芳基,合成咪唑啉衍生物由于具有缓蚀、杀菌、抗癌等活性而迅速发展 ̄[1,5]。作者曾研究过各种咪唑啉衍生物的合成 ̄[6],系采用通... 相似文献
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5-O-苯甲酰基-2,3-二脱氧-3-硝基-D-呋喃戊糖甲苷的合成研究史达清,周龙虎,高原,戴桂元(徐州师范学院化学系,徐州,221009)关键词呋喃戊糖苷,D-木糖,异构化,合成5-O-苯甲酰基-2,3-二脱氧-3-硝基-D呋喃戊糖甲苷1是合成河豚... 相似文献
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2-乙基-3,5-二甲基吡啶合成新工艺肖国民,吴平东(浙江大学二次资源化工国家专业实验室,杭州310027)2-乙基-3,5-二甲基吡啶(EDP)是合成2,3,5-三甲基吡啶[1]、3,5-二羧基吡啶和2-乙烯基-3,5-二甲基吡啶[2,3]等的重要... 相似文献
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以6-溴-3-(氯苯基甲基)-2-甲氧基喹啉(2)为起始原料,经过偶合对接反应合成了新型喹啉类抗结核药物TMC-207的衍生物6-溴-3-[2-(6-溴-2-甲氧基喹啉-3-基)-1,2-二苯乙基]-2-甲氧基喹啉,其结构经1H NMR和HR-MS确证.最佳反应条件:2 10 mmol,Et_3N 5 mL,KI 0.17 g,乙腈150 mL,于80 ℃反应6 h,收率73%. 相似文献
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Zarghi A Hajimahdi Z Mohebbi S Rashidi H Mozaffari S Sarraf S Faizi M Tabatabaee SA Shafiee A 《Chemical & pharmaceutical bulletin》2008,56(4):509-512
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism. 相似文献
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用中压汞灯(λ > 300 nm)照射4-苯乙烯基吡啶、2-苯乙烯基苯并噁唑和5-苯基-2-苯乙烯基噁唑三种杂芳基乙烯单体中任意两种的硫酸水溶液,得到三种交叉二聚体.用高效液相色谱跟踪研究了交叉光二聚反应,发现每组反应生成三种光二聚体,其中二种为单体自身的光二聚体,而另外一种是两种不同单体的交叉光二聚体.交叉二聚体通过柱色谱分离得到,其顺式头对尾结构经紫外、红外、氢谱、碳谱和元素分析确定.用紫外光谱和高效液相色谱跟踪研究了交叉光二聚体的稀溶液在低压汞灯(λmax=254 nm)照射下的光解反应.研究发现交叉二聚体能够彻底发生光解,首先生成原来的反式单体,所生成的反式单体容易发生异构化而生成顺式单体,最终建立起反顺异构化平衡. 相似文献
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V. L. Gein O. V. Bobrovskaya E. A Mashkina V. V. Novikova R. R. Makhmudov A. N. Yankin S. E. Danilov E. A. Hvolis V. D. Belonogova D. K. Gulyaev 《Russian Journal of General Chemistry》2020,90(5):822-826
A series of new methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)-sulfamoyl]phenylamino}-4-oxobut-2-enoates
was synthesized by the reaction of methyl esters of aroylpyruvic acids with
2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in a mixture of acetic
acid–ethanol (1 : 1). The obtained 4-oxobut-2-enoates reacted with silver
nitrate in ethanol–DMF (2 : 1) to form their silver salts. The antimicrobial
activity of the compounds was studied. 相似文献
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A chiral building block, (R)-2-(2,2-diethoxyethyl)-1,3-propanediol monoacetate was synthesized in high optical and chemical yields by lipase-catalyzed transesterification. From this compound, we synthesized chiral 3-substituted gamma-lactones and a new nucleoside with antiviral activity. 相似文献
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A new compound 2-(3,5-di-tert-butyl-2-hydroxyphenyl)-2-(3,4-dimethylphenyl) acetic acid dimethylamine salt ([NH2(CH3)2][C24H31O3]) was synthesized and structurally determined. It is of monoclinic system, space group P21/c with a = 14.731(2), b = 10.1185(10), c = 17.065(2) A^°, β = 98.293(10)° ,Z = 4, V = 2517.0(6)A^°^3, Dc = 1.091 g/cm^3, F(000) = 904 and Mr= 413.58. The dihedral angle defined by two benzene rings is 98.23°. 相似文献
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Some new 4-(2,6-diarylpyridin-4-yl)-2H-chromen-2-one derivatives 5a–l have been synthesized by reacting 4-(3-oxo-3-arylprop-1-enyl)-2H-chromen-2-ones 3a–c with appropriate 1-(2-oxo-2-arylethyl)pyridinium bromide salt 4a–d in the presence of ammonium acetate in refluxing glacial acetic acid. The newly synthesized compounds have been characterized by elemental and spectral analysis. 相似文献