多维约束下的军队战斗力增长模型

战斗力是军事科学研究中的一个基本概念，其基本要素是人与武器及其相互关系。已有的研究大多采用定性分析的方法探讨了战斗力的重要性、战斗力的组成、影响战斗力的因素等，缺少关于战斗力的量化分析模型。本采用量化分析方法，建立了一个基本的反映军队战斗力大小的模型，在对单因素约束下战斗力增长模型进行较详细的优化分析基础上，建立了多维约束下的战斗力增长模型。     

A Bidirectional, Diode-Pumped, Passively Mode-Locked Nd：YVO4 Ring Laser with a Low-Temperature-Grown Semiconductor Saturable Absorber Mirror

We report the operation of a bidirectional picosecond pulsed ring Nd：YVO4 laser based on a low-temperaturegrown semiconductor saturable absorber mirror. Except for the laser crystal, the six-mirror ring laser cavity has no intra-cavity elements such as focusing lens or mirror. The bidirectional mode locked pluses are obtained at the repetition rate of 117.5 MHz, pulse duration of 81 ps, power of 2 × 200 mW.     

新型小分子抗凝血药物的合成、作用机制及构效关系研究进展

以达比加群酯为代表的Ⅱa因子抑制剂和以利伐沙班为代表的Xa因子抑制剂在抗凝血药物中起到了重要作用。本文综述了已上市的新型小分子抗凝血药物的的合成、作用机制及其构效关系,并对其进行了深入分析,同时对此类药物的发展趋势和前景进行了展望。     

合成3-(2-吡啶氨基)丙酸乙酯的工艺改进

以2-氨基吡啶(2)和丙烯酸乙酯(3)为起始原料,经一步反应合成了凝血酶因子抑制剂达比加群酯的关键中间体3-(2-吡啶氨基)丙酸乙酯,其结构经1H NMR和ESI-MS确证.最佳反应条件为:2 120 mmol,n(2)∶n(3) =1.00∶1.08,于100℃回流反应24h,收率79.6％.     

1-(5-氯甲基-2-羟基-4-烷氧基)苯乙酮的合成

以2,4-二羟基苯乙酮为起始原料,经羟基烷基化和氯甲基化反应合成了3个新型查尔酮类衍生物的关键中间体——1-(5-氯甲基-2-羟基-4-烷氧基)苯乙酮,其结构经1H NMR和ESI-MS确证。     

基于两类失效的产品保修策略与出保维修优化

基于消费者对保修的需求,设计消费者偏爱的保修策略是制造商巩固市场地位、提升市场竞争力的一种战略决策。与此同时,以较低费用制定较长出保服役时间的出保维修策略也是消费者一直追求的目标。本文以两类失效产品为研究对象,首先从制造商角度将消费者偏爱的更新免费更换保修策略与产品定价相融合,开展了产品保修策略设计。其次,从消费者角度将预防维修与经典周期更换策略相融合,提出了维修—周期更换策略,且将其作为出保维修策略并对相应的性能进行了说明。通过数值实验发现,利润模型可对保修开展设计;与总费用模型作为目标函数相比,费用率模型作为目标函数可降低寿命周期费用;与经典周期更换策略相比,提出的维修—周期更换策略能使出保服役时间更长、费用率更低。     

High Power Diode-End-Pumped Nd：YAG 946-nm Laser and Its Efficient Frequency Doubling

We report a high power operation of the ^4Fa/2 → ^4I9/2 transition in diode-end-pumped laser at 946nm. The maximum output of 5.1 W is obtained with a short linear plano-concave cavity, and the slope efficiency is 24.5% at incident pump power of 23.3 W. To our knowledge, this is the highest value of the LD-pumped Nd:YAG 946 nm lasers that employ the conversional Nd:YAG rod as the gain medium. By intracavity frequency doubling with an LBO crystal, up to 982mW cw output power in the blue spectral range at 473nm is achieved at an incident pump power of 10.9 W with a compact three-element cavity, leading to optical-to-optical conversion efficiency of 9%. The conversion efficiency should be increased to 15.1%, if the rather low absorption coefficient of this Nd:YAG is considered.     

High-Power Continuous-Wave Diode-End-Pumped Intracavity Frequency Doubled Nd：YVO4 Laser at 671 nm with a Compact Three-Element Cavity

We report a high-power high-efficient continuous-wave （cw） diode-end-pumped Nd：YVO4 1342-nm laser with a short plane-parallel cavity and an efficient cw intracavity frequency-doubled red laser at 671 nm with a compact three-element cavity. At incident pump power of 20.6 W, a maximum output power of 7 W at 1342 nm is obtained with a slope effciency of 37.3%. By inserting a type-Ⅰ critical phase-matched LBO crystal as intracavity frequencydoubler, a cw red output as much as 2.85-W is achieved with an incident pump power of 16.9 W, inducing an optical-to-optical conversion efficiency of 16.9%. To the best of our knowledge, this is the highest output of diodepumped solid-state Nd：YVO4 red laser. During half an hour, the red output is very stable, and the instability of output power is less than 1%.     

Efficient stable simultaneous CW dual-wavelength diode-end-pumped Nd:YAG laser operating at 1.319 and 1.338 μm

Efficient, simple, and compact laser sources of simulta-neous emissions at multiple wavelengths have shown lotsof application foregrounds in many fields, such as opti-cal communication, photodynamic therapy (PDT), opti-cal calculation, military interaction, environmental mon-itory, laser remote sensing, laser radar, spectroanalysis,medical instrumentation, and scientific research on non-linear optical mixers[1]. In addition, it can also be usedas a pump source of Terahertz-wave generated by n…     

基于HER_2受体的新型喹唑啉衍生物的合成及其抗肿瘤活性

以取代4-[(4-硝基苯氧基)亚甲基]哌啶为原料,经还原、取代、suzuki和加成4步反应合成了6个新型的喹唑啉衍生物(5a~5f),其结构经1H NMR和ESI-MS表征。用MTT法考察了5a~5f对人脐静脉内皮细胞(HUVEC),人肺癌细胞(A-549),乳腺癌细胞(MCF-7)和人早幼粒白血病细胞(HL-60)的体外活性抑制活性。结果表明:环丙基【4-【【4-【【6-【5-{[(2-甲磺酰基乙基)氨基]甲基}呋喃-2-基】喹唑啉-4-基】氨基】苯氧基】甲基】哌啶-1-基】甲基酮(5b)抑制活性最好,其IC50分别为0.55μg·m L-1,0.18μg·m L-1,0.27μg·m L-1和5.24μg·m L-1,优于阳性对照药拉帕替尼。