共查询到19条相似文献,搜索用时 109 毫秒
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光动力治疗(Photodynamic Therapy,PDT)作为一种新兴的高效治疗方式,具有毒性低、非侵入性和可控等优点,已被广泛用于增生性皮肤疾病和肿瘤等疾病治疗.然而,已开发的PDT光敏剂在实际生物应用中仍面临诸多挑战,如:肿瘤乏氧环境降低治疗效果,光敏剂靶向性差易造成对正常组织的损伤.为了解决上述问题,研究者们开发了许多有效改善有机光敏剂治疗效果的方法.在此,主要综述了有机光敏剂的结构与性能调控策略.此外,对有机光敏剂在抗肿瘤、抗菌治疗以及余辉成像中的应用进行了介绍.最后,对有机小分子光敏剂的设计策略进行了总结与展望,以期促进该领域的发展. 相似文献
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光动力治疗(Photodynamic therapy,PDT)作为一种有别于传统癌症治疗方式的新型疗法,近些年来受到了科学家们越来越多的关注.它凭借着自身创伤性小,毒性低微,适用性好,可协同手术治疗以及可重复治疗等独特优势,在许多肿瘤的治疗方面有着广泛的应用.本文简要概述了光动力疗法的原理以及光敏剂的发展历程,并对理想光敏剂的特点作了总结.目前,以酞菁类化合物为主的第三代光敏剂已经成为光动力疗法的研究热点,然而如何提高光敏剂分子的靶向性达到精准的光动力治疗仍然是亟待解决的问题.因此,主要综述了近年来靶向性酞菁类光敏剂的研究进展,并对未来光敏剂的重点研究方向做出了展望.从目前来看,如何克服癌症低氧微环境的限制,发展Type I型不依赖氧的体系以及光穿透力强的靶向光敏剂在光动力治疗方面存在着巨大的潜质,有望成为新一代十分优良的光动力疗法用光敏剂. 相似文献
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光动力疗法(Photodynamic therapy)是基于光敏剂的化学物质的光行为.光敏化氧化指一种光敏性物质吸收特定波长的光,经过一系列物理、化学或生物反应,导致另外一种物质(底物通常未吸收光)氧化变质的现象.这种光敏性物质称为光敏剂,光敏剂本身在反应前后通常没有变化.在生物医学上,光动力学疗法(PDT)是一种应用光敏剂和光动力学反应原理来治疗各种癌症和其它恶性疾病的方法.和传统疗法(如外科手术、治疗、化疗)相比较,光动力学疗法最大的优点是可选择性诊断和治疗肿瘤,基本上不危及生命.现在临床应用的光疗药物为血咔啉衍生物(Haematoporphrin derivatien HPD),HPD治疗癌症在美国和其它国家治疗取得了许多重要的进展,但它有许多难以克服的致命缺点如成分复杂、来源困难、体内滞留时间长、毒副作用大和选择性差、波长大于600nm以上可见光区吸收弱.这些弱点限制了HPD在PDT中的应用,因此,人们积极寻找性能优良的一代光疗药物来代替HPD. 相似文献
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光动力治疗(Photodynamic therapy,PDT)是利用光敏剂在光照下促使分子氧转为具有细胞毒性的活性氧,从而达到破坏靶细胞和靶组织效应的一种治疗手段。可激活光敏剂(Activatable photosensitizers,aPSs)是指事先屏蔽了光敏效应的光敏剂,只在特定因素下,如与肿瘤相关的特异性酶、酸性pH、核酸等的激活下,光敏剂转为激活状态,从而发挥诊断或者治疗的作用。可激活光敏剂由于具有更高的选择性而备受瞩目,成为医用光敏剂领域的研究前沿热点。本文将总结和分析近年来可激活抗癌光敏剂的研究现状和构效关系,以期为后续的相关研究提供参考。 相似文献
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合成了一系列周边取代的Corrole(1, 2, 3, 4)及其镓配合物1-Ga(Py)、2-Ga(Py)、3-Ga(Py)、4-Ga(Py),通过核磁共振氢谱(1H NMR), 紫外-可见光谱, 电喷雾离子质谱(ESI-MS)的方法对其进行了表征. 研究了不同溶剂对这一系列自由Corrole 及镓Corrole 的紫外-可见(UV-Vis)吸收光谱, 稳态荧光和时间分辨荧光光谱, 将获得的荧光衰减动力学曲线采用单指数拟合并进行解卷积处理获得荧光的寿命值. 非(弱)极性溶剂对镓Corrole 紫外光谱的影响服从Bayliss 方程, 且镓Corrole 非辐射能量损失hc(ν1A-νF)与F(n)呈线性相关. 相似文献
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菁染料的研究及应用已有100多年的历史,近年来,它们在生物方面的应用研究已取得一定的成果.本文就近几年菁染料及其衍生物在生物医疗方面的研究及进展情况加以综述,特别阐述了这类染料用作荧光探针在生物大分子标识以及作为光敏剂在光动力疗法(PDT)中用于恶性肿瘤的诊断与治疗这两方面的研究进展. 相似文献
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Chi Kwong Chang 《中国化学快报》2009,20(1):21-24
Chiral bis-corrole 1 and 2 were prepared by reaction of(s)-2,2′-bis(bromomethyl)-1,1′-binaphthyl and 10-(4-hydroxylphenyl)- 5,15-bis(pentafluorophenyl)corrole or 10-(3-hydroxylphenyl)-5,15-bis(pentafluorophenyl)corrole in DMF at 60℃in the presence of anhydrous K_2CO_3 with an isolated yield~8%.Both 1 and 2 exhibit unsymmetrical induced circular dichroism(ICD)in the soret band with positive exciton chirality. 相似文献
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Lan Yu Qi Wang Lu Dai Wei-Ying Li Rong Chen Mian HR Mahmood Hai-Yang Liu Chi-Kwong Chang 《中国化学快报》2013,24(6):447-449
Pseudo-first order reaction rate constants of 5,10,15-tris(pentafluorophenyl)corrole Mn(V)-oxo (F15CMn(V)-oxo),5,15-bis(pentafluorophenyl)-10-(phenyl)corrole Mn(V)-oxo(F10CMn(V)-oxo),5,15- bis(phenyl)-10-(pentafluorophenyl)corrole Mn(V)-oxo(F5CMn(V)-oxo) and 5,10,15-tris(phenyl)corrole Mn(V)-oxo(F0CMn(V)-oxo) with a series of alkene substrates in different solvents were determined by UV-vis spectroscopy.The results indicated that the oxygen atom transfer pathway between Mn(V)-oxo corrole and alkene is solvent-dependent. 相似文献
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咔咯钴(Ⅲ)配合物与DNA的相互作用及抗肿瘤活性 总被引:1,自引:0,他引:1
合成了10-(4-羟基苯基)-5,15-二(五氟苯基)咔咯钴(Ⅲ)配合物(1-Co)和10-(4-吩噻嗪苯基)-5,15-二(五氟苯基)咔咯钴(Ⅲ)配合物(2-Co),并采用核磁共振波谱、质谱和紫外-可见光谱等对其结构进行了表征,利用紫外光谱、荧光光谱、圆二色谱、黏度测试和琼脂糖凝胶电泳等技术研究了配合物1-Co和2-Co与小牛胸腺DNA(ct-DNA)之间的相互作用.结果表明,配合物1-Co和2-Co与DNA之间的作用模式为外部结合,且在光照下均能引发DNA断裂.细胞毒性实验结果表明,配合物1-Co和2-Co具有很低的暗细胞毒性,但在光照条件下均能有效抑制H460,He La,A549等肿瘤细胞株增殖,表明配合物1-Co和2-Co在光动力治疗中具有潜在的应用价值.细胞核染色和线粒体膜电位检测结果表明,在光照条件下配合物2-Co可能是通过氧化损伤线粒体的途径抑制肿瘤细胞增殖. 相似文献
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The synthesis of a new compound, 10-(4-aminophenyl)-5,15-dimesitylcorrole, and its application for the preparation of optical chemical pH sensors is described. The dye materials were immobilized in a sol-gel glass matrix and characterised upon exposure to aqueous buffer solutions. The response of the sensor is based on the fluorescence intensity changing of corrole owing to multiple steps of protonation and deprotonation. Due to its containing several proton sensitive centers, the 10-(4-aminophenyl)-5,15-dimesitylcorrole based optode shows a wider response range toward pH than that of tetraphenylporphyrin (TPPH(2)) and 5,10,15-tris(pentafluorophenyl)corrole (H(3)(tpfc)). It shows a linear pH response in the range of 2.17-10.30. The effect of the composition of the sensor membrane has been studied and the experimental conditions were optimized. The optode showed good reproducibility and reversibility, and common co-existing inorganic ions did not show obvious interference to its pH measurement. 相似文献
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Zhang R Harischandra DN Newcomb M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(19):5713-5720
Corrole-manganese(V)-oxo intermediates were produced by laser flash photolysis of the corresponding corrole-manganese(IV) chlorate complexes, and the kinetics of their decay reactions in CH2Cl2 and their reactions with organic reductants were studied. The corrole ligands studied were 5,10,15-tris(pentafluorophenyl)corrole (H3TPFC), 5,10,15-triphenylcorrole (H3TPC), and 5,15-bis(pentafluorophenyl)-10-(p-methoxyphenyl)corrole (H3BPFMC). In self-decay reactions and in reactions with substrates, the order of reactivity of (Cor)Mn(V)(O) was TPC > BPFMC > TPFC, which is inverted from that expected based on the electron-demand of the ligands. The rates of reactions of (Cor)Mn(V)(O) were dependent on the concentration of the oxidant and other manganese species, with increasing concentrations of various manganese species resulting in decreasing rates of reactions, and the apparent rate constant for reaction of (TPFC)Mn(V)(O) with triphenylamine was found to display fractional order with respect to the manganese-oxo species. The kinetic results are consistent in part with a reaction model involving disproportionation of (Cor)Mn(V)(O) to give (Cor)Mn(IV) and (Cor)Mn(VI)(O) species, the latter of which is the active oxidant. Alternatively, the results are consistent with oxidation by (Cor)Mn(V)(O) which is reversibly sequestered in non-reactive complexes by various manganese species. 相似文献
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以五氟苯甲醛和吡咯经缩合反应合成了五氟苯基二吡咯烷烃(1); 1与3-氯-4-羟基苯甲醛经缩合反应合成了一个新的10-位苯环被氯原子取代的单羟基自由咔咯--10-(3-氯-4-羟苯基)-5,15-二(五氟苯基)咔咯(〖STHZ〗2〖STBZ〗),收率12.0%,其结构经UV-Vis, 1H NMR, 19F NMR, HR-ESI-MS和X-射线单晶衍射表征。琼脂糖凝胶电泳实验发现:2在光照下能够有效引起超螺旋质粒pBR 322 DNA发生断裂,当浓度为100 μmol·L-1时,活性最强,断裂百分比为68%。 相似文献
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Dr. Kento Ueta Akito Nakai Dr. Takayuki Tanaka Prof. Dr. Atsuhiro Osuka 《化学:亚洲杂志》2021,16(16):2253-2256
8,12-Dibromo-5,15-bis(pentafluorophenyl)corrole and its Ag(III) complex were prepared via intramolecular oxidative coupling of a 8,12-dibromobilane precursor. The Ag(III) complex was allowed for further transformation via Suzuki coupling reaction. Thus, 2-aminophenyl group was coupled at one of the β-positions, and subsequent demetalation followed by oxidation with MnO2 afforded 8,10-fused iminoisocorrole in good yields. The iminoisocorrole exhibited weak antiaromaticity due to the C(+)−N(−) polarized resonance contribution as evidenced by 1H NMR spectrum, UV/vis absorption spectra, cyclic voltammetry, and theoretical calculations. 相似文献
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Shota Ooi Dr. Tomoki Yoneda Dr. Takayuki Tanaka Prof. Dr. Atsuhiro Osuka 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(21):7772-7779
5,10‐Bis(pentafluorophenyl)corrole ( 5 ) and 5,15‐bis(pentafluorophenyl)corrole ( 9 ) have been synthesized as meso‐free corroles by rational synthetic routes. Both the structures of these corroles have been unambiguously revealed by X‐ray diffraction analysis and their optical and electrochemical properties have been studied. Chlorination and oxidative dimerization of 5 and 9 have been explored, which revealed a marked different reactivity of the free meso‐positions in 5 and 9 . 10‐Chlorinated corrole 11 was effectively prepared by the reaction of 9 with Palau‘chlor in the presence of 1 % pyridine whereas 5‐chlorinated corrole 12 was obtained in a trace amount from similar chlorination of 5 . 5,5′‐Linked corrole dimer 13 was produced by reaction of 5 with AgNO2 in a good yield, whereas 10,10′‐linked corrole dimer 14 was formed in a moderate yield by the reaction of 9 with [bis(trifluoroacetoxy)iodo]benzene. Observed large electronic interaction between the two corroles in 13 as compared with that in 14 has been ascribed mainly to conformational flexibility of the former, which allows more coplanar conformation. 相似文献