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1.
R-四氢噻唑-2-硫酮-4-羧酸反应得到有光学活性的二聚体酰胺双四氢噻唑-2-硫酮并二氧代氢化吡嗪,用半经验量子化学PM3方法研究了反应物、中间产物和二聚体的电子结构. 相似文献
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(R)-N-乙酰四氢噻唑-2-硫酮-4-羧酸与醇反应,在SOCl2存在下得到乙酸酯及四氢噻唑-2-硫酮-4-羧酸酯;在碳酸钾存在下得到乙酸酯及四氢噻唑-2-硫酮-4-羧酸;在二环己基碳二亚胺(DCC)存在下得到缩水产物N-乙酰四氢噻唑-2-硫酮-4-羧酸酯。 相似文献
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(R)—N—(γ—烃基—δ—酮己酰基)四氢噻唑—2—硫酮—4—羧酸乙酯的合成及… 总被引:3,自引:0,他引:3
γ-甲基-δ酮己酸,γ-异丙基-δ-酮己酸在碘化N-甲基-2-氯吡啶盐存在下分别用(R)-四氢噻唑-2-硫酮-4-羧酸乙酯反应,得到光学活性的(R)-N-(γ-甲基-δ-酮己酰基)四氢噻唑-2硫酮-4羧酸乙酯(la)及光学活性的(R)-N-(γ-异丙基-δ-酮己酰基)四氢噻唑-2-硫酮-4-羧酸乙酯(1b),la,lb分别同(R,S)-α-苯乙胺反应得到光学活性的酰胺2a,2b,同时使(R,S)= 相似文献
5.
N—烃氧丙酰基四氢噻唑—2—硫酮的合成 总被引:1,自引:0,他引:1
在三聚氯氰存在下由烃氧丙酸与四氢噻唑-2-硫酮反应得到N-烃氧丙酰四氢噻哇-2-硫酮(2a-i),由2a,c-h与格氏试剂反应得到烃氧乙基苯基酮(3a,c-h).产物2a-i未见报道. 相似文献
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(R)-N-(γ-烃基-δ-酮己酰基)四氢噻唑-2-硫酮-4-羧酸乙酯的合成及其同(R,S)-α-苯乙胺的反应 总被引:1,自引:0,他引:1
γ-甲基-δ-酮己酸,γ-异丙基-δ-酮己酸在碘化N-甲基-2-氯吡啶盐存在下分别同(R)-四氢噻唑-2-硫酮-4-羧酸乙酯反应,得到光学活性的(R)-N-(γ-甲基-δ-酮己酰基)四氢噻唑-2-硫酮-4-羧酸乙酯(1a)及光学活性的(R)-N-(γ-异丙基-δ-酮己酰基)四氢噻唑-2-硫酮-4-羧酸乙酯(1b)。1a,1b分别同(R,S)-α-苯乙胺反应得到光学活性的酰胺2a,2b,同时使(R,S)-α-苯乙胺拆分,得到光学活性的α-苯乙胺。 相似文献
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R—四氢噻唑—2—硫酮—4—羧酸同R.S—氨基醇的手性识别反应 总被引:2,自引:0,他引:2
R-四氢噻唑-2-硫酮-4-羧酸同R.S-亮氨醇、R.S-蛋氨醇、R.S-苯丙氨醇和R.S-色氨醇反应分别得到光学活性非对映体过剩的铵盐;R-四氢噻唑-2-硫酮-4-羧酸.S-色氨醇,同时分离出光学活性对映体过剩的R-亮氨醇,S-氨蛋醇,S-苯丙氨醇及R-色氨醇,用半经验的量子化学PM3方法研究了氨基醇的最优构型和电子结构,得到了铵盐的最优几何构型。 相似文献
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李叶芝 《高等学校化学学报》1998,19(6):955-958
α-溴代丙酰氯分别同四氢噻唑-2-硫酮及-四氢噻唑-2-硫酮-4-羧酸乙酯反应得四氢噻唑-2--α-溴代丙酰硫酯2a及光学活性-4-乙氧羰基四氢噻唑-2-α溴代丙酰硫酯2b。 相似文献
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We have developed a liquid-phase synthesis of combinatorial libraries of new disubstituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and trisubstituted 4-oxo-3,4-dihydroquinazoline-2-thioles. The former were prepared using two general procedures: (i) cyclization of substituted methyl anthranilates with isothiocyanates, or (ii) cyclization of substituted 2-(methylcarboxy)benzeneisothiocyanates with primary amines or hydrazines. 4-Oxo-3,4-dihydroquinazoline-2-thioles were prepared by S-alkylation of disubstituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines with alkyl or aryl halides. The hydrolysis of methyl benzimidazo[1,2-c]quinazoline-6(5H)-thione-3-carboxylate led to the corresponding acid. This acid was utilized in the synthesis of new benzimidazo[1,2-c]quinazoline-6(5H)-thione-3-carboxamide and S-substituted 6-mecaptobenzimidazo[1,2-c]quinazoline-3-carboxamide libraries. 相似文献
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Ruth-Maria Olk A. Rhr J. Sieler K. Khler R. Kirmse W. Dietzsch E. Hoyer B. Olk 《无机化学与普通化学杂志》1989,577(1):206-216
Coordination Chemistry of 1,3-Dithiole-2-thione-4,5-diselenolate (dsit) — Comparison with 1,3-Dithiole-2-thione-4,5-dithiolate (dmit) Synthesis and properties of metal(II) and/or metal(III) bis-chelates of 1,3-dithiole-2-thione-4,5-diselenolate (dsit) of general type (Bu4N)n[M(dsit)2] (n = 2: M ? Zn, Cd, Hg, Cu, Ni, Pd, Pt; n = 1: M ? Ni, Au) are described. By comparison of the ir, 13C nmr, epr spectra, cyclovoltammetric data, and x-ray investigations (nickel-bis-chelates) of chelates of dsit and those of the chelates of 1,3-dithiole-2-thione-4,5-dithiolate (dmit) the consequences of selenium for sulfur substitution on position 4 and 5 of the heterocyclic ligand are discussed. 相似文献
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Hassan Pajouhesh Mahmonir Hosseini-Meresht Seyed Hossein Pajouhesh Ken Curry 《Tetrahedron: Asymmetry》2000,11(24):4955-4958
The preparation of both enantiomers of 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), 1, an analogue of the neuroexcitant 2-amino-3-(3-hydroxy-5-methyl-4-yl) propanoic acid (AMPA) is described. The enantiomerically pure glycine derivative tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (BOC-BMI) was coupled with 4-bromomethyl-2-methoxymethyl-5-tert-butylisoxazolin-3-one 6 to give the intermediates (2R,5R)-8 and (2S,5S)-8. These alkylated products were hydrolyzed under mild conditions to give enantiopure (R)-1 and (S)-1 with e.e.'s in excess of 99% in 33% overall yield. 相似文献
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Ruth-Maria Olk Christiane Semmelmann R. Kirmse K. Khler E. Hoyer B. Olk 《无机化学与普通化学杂志》1990,581(1):59-68
Coordination Chemistry of 1,3-Thiaselenole-2-thione-4,5-dithiolate (dmits) – Comparison with 1,3-Dithiole-2-thione-4,5-dithiolate (dmit) Synthesis and properties of metal(II) and/or metal(III)-bis-chelates of 1,3-thiaselenole-2-thione-4,5-dithiolate (dmits) of the general type (Bu4N)n[M(dmits)2] (n = 2: M = Zn, Cd, Hg, Ni, Cu, Pd; n = 1: M = Au, Ni) are described. By comparison of the i.r., 13C-n.m.r., epr spectra and cyclovoltammetric data of chelates of dmits and those of 1,3-dithiole-2-thione-4,5-dithiolate (dmit) the consequences of the substitution of selenium for sulfur on position 3 of the heterocyclic ligand dmit are discussed. 相似文献
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(R)-Malic, (S)-malic, (R)citramalic, (S)-citramalic, (2R,3S)-2-hydroxy-3-methyl-succinic and (2R,3S)-2,3-dimethyl-2-hydroxysuccinic acid were prepared on scales up to 25 mmol by stereospecific addition of water to different 2-butene-1,4-dioic acid derivatives catalyzed by resting cells of Clostridium formicoaceticum (Scheme 1). The (3R)-monodeuterio (R)- and (S)-malic acid as well as (R)- and (S)-citramalic acid were prepared using freeze-dried cells in 2H2O-buffer. The stereochemical purity of the products was in most cases ≥ 99%. 相似文献
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CuCl-catalysed cycloaddition of methyl propiolate to O,O-diisopropyl (1S,2R,3S)- and (1R,2R,3S)-, or O,O-dibenzyl (1S,2R,3S)-, (1R,2R,3S)-, (1S,2R,3R)- and (1R,2R,3R)-4-azido-1,2,3-trihydroxy-2,3-O-isopropylidenebutylphosphonates followed by methylation of HO–C-1, ammonolysis of methoxycarbonyl groups and hydrolysis of isopropylidene acetals led to diisopropyl (1S,2R,3S)- and (1R,2R,3S)-4-(4-carbamoyl-1,2,3-triazol-1-yl)-2,3-dihydroxy-1-methoxybutylphosphonates or, after hydrogenolytic removal of benzyl groups, to (1S,2R,3S)-, (1R,2R,3S)-, (1S,2R,3R)- and (1R,2R,3R)-4-(4-carbamoyl-1,2,3-triazol-1-yl)-2,3-dihydroxy-1-methoxybutylphosphonic acids. 相似文献
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(S)-2-Phenylpropionic acid was stereoselectively obtained by the AgBF4-catalyzed phenyl-rearrangement of (S)-2-chloropropiophenone dimethyl acetal, while the photoirradiation of (S)- or (R)-2-chloropropiophenone afforded partially racemized (S)- or (R)-2-phenylpropionic acid, respectively. An intramolecular SN2 mechanism is suggested for the former rearrangement. The latter result is indicative of the intervention of an ion or radical intermediate in the photoinduced phenyl-rearrangement. 相似文献
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I 《Journal of Molecular Structure》2002,610(1-3):33-40
Crystal and molecular structures of (2R,3R)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrole-3-carboxylic acid (I) and (2R*,3R*)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrole-3-carboxylic acid (II) are presented. The alternative packings were studied using ab initio quantum-chemical methods. Energies of hydrogen bonds for real and model cases are discussed. Infinite chains of molecules instead of carboxylic acid dimers were observed. 相似文献
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Hiroki Sone Takayuki Nemoto Hiroyuki Ishiwata Makoto Ojika Kiyoyuki Yamada 《Tetrahedron letters》1993,34(52):8449-8452
Dolastatin D (1), a cytotoxic cyclic depsipeptide possessing the novel β-amino acid (2R,3R)-3-amino-2-methylbutanoic acid [(2R,3R]-3] as a component, has been isolated from the Japanese sea hare Dolabella auricularia. The absolute stereostructure of 1 was elucidated on the basis of spectroscopic analysis and chemical degradation and was further confirmed by synthesis. 相似文献