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聚苯硫醚副产物浆料的分离及氯化锂的回收研究 总被引:2,自引:1,他引:1
聚苯硫醚(PPS)的工业合成采用对二氯苯和硫化钠为原料,N-甲基-2-吡咯烷酮(NMP)为溶剂,氯化锂为助剂,经加压缩聚反应而成.该反应除了获得PPS外,还产生一部分副产物淤浆,有必要对其组成物进行分离回收和资源化利用.本文采用四氢呋喃(THF)为添加剂对这种副产物淤浆进行了分离研究,并对其中的锂盐进行了回收研究.结果表明,采用THF添加剂可以较为容易地将浆料分离为PPS低聚物、NMP以及无机盐,采用有机溶剂提取法可以回收氯化锂,LiCl的回收率可达40%. 相似文献
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FOX-7的合成和反应机理研究 总被引:11,自引:0,他引:11
以2-甲基咪唑为原料合成出1,1-二氨基-2,2-二硝基乙烯(FOX-7)并进行了结构表征,从中间体过滤母液中分离出副产物2-甲基-4(5)-硝基咪唑和仲班酸.直接合成的2-甲基-4(5)-硝基咪唑和仲班酸,最佳收率分别为67.3%和63.3%.首次提出了一个较为完整而详细的合成FOX-7的反应机理,硝基重排成亚硝酸酯是反应的关键步骤.FOX-7主要是通过2-甲基咪唑→2-甲基-4(5)-二氢-5-咪唑啉酮→2-(二硝基亚甲基)-5,5-二硝基-4-咪唑烷二酮→2-(二硝基亚甲基)-4,5-咪唑烷二酮→FOX-7步骤形成.论述了各中间体形成的详细过程并进行了证明,应用该机理解释了硝化过程中主产物和副产物的变化规律. 相似文献
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苏莉 《理化检验(化学分册)》2006,42(10):793-795
采用高效液相色谱法对高效除草剂盖草能的中间体2-氯-5-三氯甲基吡啶(TCMP)及相关化合物的分析条件进行了探讨和优化。使用Zorbax eclipse XDB-C18色谱柱,以乙腈-水(30+70,体积比)为流动相,控制流速1 mL.min-1,采用紫外可变波长检测器,检测波长为240 nm,方法的线性关系良好,相关系数为0.998 4,回收率为99.05%。在实样分析中同时测定了合成TCMP过程中的两个主要副产物2-氯-5-氯甲基吡啶和2-氯-3-三氯甲基吡啶。 相似文献
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A novel Mn(Ⅱ) complex Mn2(phen)2(p-MBA)4(H2O) has been hydrothermally synthesized by the reaction of p-methyl benzoic acid (p-MBA) with 1,10-phenanthroline (phen). Crystal data for this complex: monoclinic, space group C2/c, a= 2.3328(3), b =1.5549(2), c = 1.5557(2) nm, β = 121.726(2)°, V= 4.7997(11) nm^3, Mr = 1028.85, Dc = 1.424 g/cm^3, Z = 4, F(000) = 2128, μ(MoKa) = 0.590mm^-1, GOOF = 1.060, R = 0.0333 and wR = 0.0767. In the crystal, each Mn(Ⅱ) ion is coordinated by two nitrogen atoms from one o-phenanthroline molecule, three oxygen atoms from three p-methyl benzoic acids and one oxygen atom from one water molecule, giving a six-coordinate distorted octahedral coordination geometry. Two neighboring Mn(Ⅱ) ions are bridged by two p-methyl benzoic acid groups and one water molecule, and their end positions are respectively coordinated by one 1,10-phenanthroline and one p-methyl benzoic acid molecule, giving a binuclear cage structure, of which the Mn(Ⅱ)…Mn(Ⅱ) distance is 0.3502 nm. 相似文献
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The synthesis of difluoronitroacetanilide and its p-methyl and m-methoxyl derivatives and their reduction by diborane in tetrahydrofuran to the corresponding N-difluoronitroethylanilines is described. Yields on the acetanilides ranged from 13 to 43% and on the anilines from 50 to 64%. 相似文献
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Chan-Young Jeon Hee-Jun Kim Jae-Yong Lee Jaebong Kim Sung-Chan Kim Jae-Bong Park 《Experimental & molecular medicine》2010,42(5):335-344
Rat pheochromocytoma (PC12) cells have been used to investigate neurite outgrowth. Nerve growth factor (NGF) has been well known to induce neurite outgrowth from PC12 cells. RhoA belongs to Ras-related small GTP-binding proteins, which regulate a variety of cellular processes, including cell morphology alteration, actin dynamics, and cell migration. NGF suppressed GTP-RhoA levels after 12 h in PC12 cells and was consistently required for a long time to induce neurite outgrowth. Constitutively active (CA)-RhoA suppressed neurite outgrowth from PC12 cells in response to NGF, whereas dominant-negative (DN)-RhoA stimulated it, suggesting that RhoA inactivation is essential for neurite outgrowth. Here, we investigated the mechanism of RhoA inactivation. DN-p190RhoGAP abrogated neurite outgrowth, whereas wild-type (WT)-p190RhoGAP and WT-Src synergistically stimulated it along with accelerating RhoA inactivation, suggesting that p190RhoGAP, which can be activated by Src, is a major component in inhibiting RhoA in response to NGF in PC12 cells. Contrary to RhoA, Rap1 was activated by NGF, and DN-Rap1 suppressed neurite outgrowth, suggesting that Rap1 is also essential for neurite outgrowth. RhoA was co-immunoprecipitated with Rap1, suggesting that Rap1 interacts with RhoA. Furthermore, a DN-Rap-dependent RhoGAP (ARAP3) prevented RhoA inactivation, abolishing neurite formation from PC12 cells in response to NGF. These results suggest that NGF activates Rap1, which, in turn, up-regulates ARAP3 leading to RhoA inactivation and neurite outgrowth from PC12 cells. Taken together, p190RhoGAP and ARAP3 seem to be two main factors inhibiting RhoA activity during neurite outgrowth in PC12 cells in response to NGF. 相似文献
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For its high reactivity and very short half-life, the hydroxyl radical (OH.) in vivo is very difficult to be detected. Usually, it is indirectly quantified by determining 2,3-dihydroxybenzoic acid (2,3-DHBA) and 2,5-dihydroxybenzoic acid (2,5-DHBA), which are the reaction products of salicylic acid (SA) and OH.. Because 2,5-DHBA could be directly formed by the P(450) enzyme, only 2,3-DHBA is regarded as the real biomarker of OH.in biological studies. But the very low concentration of OH* in human bodies makes its determination very difficult and complicated. In this paper, a simple online stacking capillary zone electrophoresis coupled with amperometric detection (CZE-AD) method was explored to improve the detection sensitivity of 2,3-DHBA to reach the requirements in biological analysis. A mixture solution of 12.5 mmol/L Na(2)B(4)O(7)-25 mmol/L NaH(2)PO(4) (pH 7.9) was used as the running buffer and p-methyl benzoate was selected as a suitable stacker. The effects of the concentration, pH value, and injection time of p-methyl benzoate on stacking efficiency were carefully studied. Under the optimum stacking CZE-AD conditions, the detection sensitivity of 2,3-DHBA was improved about 20-fold and its detection limit reached the 10(-9) mol/L level. The experimental results showed that this was a potential method to determine OH* in vivo. 相似文献
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DL-2,5,6-trifluoro-3,4-dihydroxyphenylalanine (trifluorodopa) hydroiodide has been synthesized from hexafluorobenzene in a six-step procedure. The key step is the methoxylation of p-methyl tetrafluoroanisole. This reaction affords the desired 2,5,6-trifluoro-3,4-dimethoxytoluene, which is separated by preparative glc from 3,5,6-trifluoro-2,4-dimethoxytoluene. Attempts to obtain trifluorodopa by ether cleavage of the appropriately substituted dihydrobenzodioxin have not been successful. 相似文献
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This letter illustrates for the first time the preparation of p-methyl methacrylate/n-butyl acrylate/heptadecafluorodecyl methacrylate (p-MMA/nBA/FMA) colloidal dispersions containing up to 15% w/w FMA, which is accomplished by the utilization of biologically active phospholipids (PLs) and ionic surfactants. The use of monomer-starved conditions during emulsion polymerization and the utilization of 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), sodium dodecyl sulfate (SDS), and phosphoric acid bis(tridecafluoro-octyl) ester ammonium salt (FSP) as surfactants, which function as transfer and dispersing agents, facilitate a suitable environment for the polymerization of p-MMA/nBA/FMA colloidal dispersions that exhibit nonspherical particle morphologies. Such nonspherical particles upon coalescence form phase-separated films with unique surface properties. 相似文献
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McFarlane EH Dawe GS Marks M Campbell IC 《Bioelectrochemistry (Amsterdam, Netherlands)》2000,52(1):23-28
The effects of low electromagnetic field (EMF) exposure (4.5-15.8 microT, 50 Hz AC) on neurite outgrowth and cell division in rat PC12 pheochromocytoma cells were examined. The study involved two separate experimental series in which culture conditions during exposure to the magnetic fields differed. In series 1 (14 experiments in which culture conditions were not strongly conducive to cell differentiation [15% serum]), exposure to 4.5-8.25 microT for 23 h significantly inhibited neurite outgrowth by 21.5 +/- 1.3% (by Manova, p = 0.003). In contrast, in series 2 (12 experiments in which culture conditions promoted cellular differentiation [4% serum]), exposure to 4.35-8.25 microT for 23 h significantly stimulated neurite outgrowth by 16.9 +/- 1.1% (by Manova, p = 0.009). Thus, in both series, exposure to a narrow range of low EMF has significant, but opposite effects on neurite outgrowth. Exposure to higher fields, 8.25-12.5 microT (series 1) and 8.25-15.8 microT (series 2) had no significant effect on neurite outgrowth. These data, when considered with other reports, suggest that neuronal differentiation can be altered by low level EMF exposure. While this may not be detrimental, it merits further research. At present, the reasons for the significant changes in neurite outgrowth being confined to the same narrow field strength are unclear. As stated above, culture conditions in series 2 were more conducive to cell differentiation than those in series 1. This is reflected in the lower number of cells in control samples in series 2, at the end of the 23-h incubation, than in series 1 (- 16.9 +/- 1.7%, p = 0.003). As the same numbers were plated in both series, the medium used in series 1 allows more of the PC12 cells to divide; this is consistent with some cells reverting to a non-neuronal adrenal chromaffin phenotype [L. Greene, A. Tischler. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U. S. A., 73 (1976) 2424-2426]. Exposure to both ranges of magnetic fields (4.35-8.25 and 8.25-15.8 microT) has no effect on cell division. Thus, there is no evidence in this study that there is a mitogenic effect arising from low EMF exposure. 相似文献
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M. A. Ryashentseva Kh. M. Minachev V. V. Dorogov N. S. Prostakov 《Chemistry of Heterocyclic Compounds》1972,8(1):82-84
The corresponding substituted piperidines were obtained in yields from 40 to 99.5% by the hydrogenation of 2,5-dimethyl-4-phenylpyridine and 2,5-dimethyl-4-[p-methyl(p-ethyl)benzyl]pyridines in the presence of rhenium, platinum, and palladium sulfides.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 88–90, January, 1972. 相似文献
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[Co(p—Me—PPA)2(H2O)2]Cl的合成及其催化环己烯氧化反应的研究 总被引:5,自引:0,他引:5
环己烯的选择性氧化是一个较难的课题,原冈是环己烯存在两个活性部位易工发生氧化反应:一是烯两基位的氢易被氧化生成环己烯醇和环己烯酮的产物:二是双键易被氧化成环氧化物、环己酮或C—CXX键断裂生成难成酸等。因此人们一直在努力寻找具有高活性,高选择性的催化剂用以催化环己烯的氧化反应[’*’]。本文合成的K叶卜*卜呷A从比0)。厂1,在0。作氧源下m于催化环己烯氧化反应时呈现出较好的转化率和环己烯酮选择性。1【Co(P-Me-PPA)。(H。0)。」C!的合成采m2一毗咙甲酸和p一甲基本胺作原料合成了【… 相似文献