N—取代三氯乙酰胺合成新脲类化合物及其生物活性的研究：Ⅳ.1—呋喃酰？…

用Ｎ－取代三氯乙酰胺与呋喃甲酰胺肼反应，合成了６个新的１－呋喃酰基－４－芳基氨基脲。其结构经元素分析，ＩＲ和＾１Ｈ ＮＭＲ所证实。生物活性测试表明，其中某些化合物具有一定的除草活性。     

5－O－苯甲酰基－2，3－二脱氧－3－硝基－D－呋喃戊糖甲苷的合成研究

５－Ｏ－苯甲酰基－２，３－二脱氧－３－硝基－Ｄ－呋喃戊糖甲苷的合成研究史达清，周龙虎，高原，戴桂元（徐州师范学院化学系，徐州，２２１００９）关键词呋喃戊糖苷，Ｄ－木糖，异构化，合成５－Ｏ－苯甲酰基－２，３－二脱氧－３－硝基－Ｄ呋喃戊糖甲苷１是合成河豚...     

新型N1-(2-呋喃烷基)-5-氟脲嘧啶的α-羟基(硫代)膦酸酯衍生物的合成

通过对N^1-(2－呋喃烷基）－5－氟脲嘧啶的氧化以及与O,O－二乙基硫代亚磷酸酯的加成反应合成了新型N^1-(2－呋喃烷基）－5－氟脲嘧啶的α-羟基（硫代）膦酸酯衍生物,进一步以间氯过氧苯甲酸氧化得到相应的α-羟基膦酸酯衍生物 。     

2—硫代磷酸酯基—3,4—二氢呋喃并喹啉化合物的合成和抑菌活性

６－取代基－２－氧－３，４－二氢呋喃并喹啉类化合物用氢化钠还原所生成的醇钠与硫代磷酰氯综合制备３，４－二氢呋喃并喹啉化合物，通过×１ＨＮＭＲ，ＭＳ和元素分析鉴定了它们的结构，并初步测试了它们的抑菌活性。     

2－硫代磷酸酯基－3，4－二氢呋喃并喹啉化合物的合成和抑菌活性

６－取代基－２－氧－３，４－二氢呋喃并喹啉类化合物用氢化钠还原所生成的醇钠与硫代磷酰氯缩合制备３，４－二氢呋喃并喹啉化合物，通过￣１ＨＮＭＲ，ＭＳ和元素分析鉴定了它们的结构，并初步测试了它们的抑菌活性．     

N-芳基-5-芳基-2-呋喃甲酰胺和N-5-芳基-2-呋喃甲酰基-N′-芳氧基乙酰基肼的合成及生物活性的研究

５－芳基－２－呋喃甲酸及其衍生物具有调节植物生长等作用［４］．我们通过大量的实验，选用ＰＴＣ法，利用５－芳基－２－呋喃甲酰氯与芳胺和芳氧基乙酰肼反应，合成了新化合物Ⅱ和Ⅳ：ＲＣＯＣｌＯ（Ⅰ）ＡｒＮＨ２／ＰＥＧ－４００→ＲＣＯＮＨＡｒ（Ⅱ）ＯＮａＯＨ／...     

二氯菊酸2－甲基－3－（2－呋喃基）－2－丙烯酯的合成

报导了一种新拟除虫菊酯的设计和合成。标题化合物是由二氯菊酰氯与新自制的２－甲基－３－（２－呋喃基）－２－丙烯－１－醇酯化合成。     

α-呋喃酯类化合物在EI电离条件下的质谱特征

总结和归属了α－呋喃甲酸酯、α－呋喃甲醇酯、α－呋喃丙烯酸酯以及α－呋喃环在电子电离质谱（ＥＩＭＳ）中的主要裂解方式和特征,给出各化合物主要碎片离子的来源和结构。上述３类不同α－呋喃酯在ＥＩＭＳ中的基峰离子分别为９５、８１和１２１。α－呋喃离子是３类α－呋喃酯的共同碎片离子,由其裂解产生的２９、３８和４１的碎片离子也是３类α－呋喃酯的共同特征离子     

从呋喃甲醛制备4－(1,2－亚乙二氧基)环己酮的系列合成

从呋喃甲醛制备４－（１，２－亚乙二氧基）环己酮的系列合成蒋本国，葛树丰，叶秀林（北京大学化学与分子工程学院１００８７１）４－（１，２－亚乙二氧基）环己酮（５）及其脱羧前的母体化合物４－（１，２－亚乙二氧基）环己酮－２－羧酸乙酯（４）都是反应性能很强的...     

二氯菊酸2—甲基—3—（2—呋喃基）—2—丙烯酯的合成

报导了一种新拟除虫菊酯的设计和合成，标题化合物是由二氯菊酰氯与新自制的２－甲基－３－（２－呋喃基）－２丙烯－１－醇酯化合成。     

1-(2-苯并呋喃酰基)愈创兰烃薁的合成

在路易斯酸作用下, 以氯乙酰氯为酰基化试剂, 对愈创兰烃薁进行了酰化反应研究, 将氯乙酰化产物与水杨醛在温和反应条件下进行缩合, 以较好的收率、高选择性地得到1-(2-苯并[b]呋喃酰基)兰烃薁类衍生物, 其结构经1H NMR, IR及元素分析等得以证实.     

3-(2-苯并呋喃酰基)薁-1-羧酸甲酯的有效合成

以苯基三甲铵三溴盐(PTAB)为溴化试剂, 对3-乙酰基薁-1-羧酸甲酯进行了溴代反应研究, 将其单溴代产物与水杨醛在温和反应条件下进行缩合, 以极优的收率高选择性得到3-(2-苯并[b]呋喃酰基)薁-1-羧酸甲酯类衍生物, 其结构经¹H NMR, IR及元素分析等得以证实.     

Synthesis of Isomeric (Methoxycarbonyl)furoyl Phosphonates and Their Reaction with Ethoxycarbonylmethylenetriphenylphosphorane

Addition of diethyl- and diisopropyl hydrogen phosphites to isomeric (methoxycarbonyl)-2- and 3-furaldehydes in the presence of sodium ethylate or potassium fluoride led to the formation of the corresponding hydroxyphosphonates. When treated with DMSO-acetic anhydride mixture at room temperature these compounds were selectively oxidized to the corresponding furoyl phosphonates. 2-Methoxycarbonyl-3- furoyl phosphonate was synthesized via the Arbuzov reaction from 2-methoxycarbonyl-3-furoyl chloride and triethyl phosphite. The obtained isomeric (methoxycarbonyl)furoylphosphonates regardless of the structure of heterocyclic fragment react with ethoxycarbonylmethylenetriphenylphosphorane to give ethyl 3-(furyl)-3-(dialkoxyphosphoryl) acrylates with trans-location of phosphoryl and carbonyl groups against the double bond.     

Synthesis and Bioactivity of Novel N,N′‐Diacylhydrazine Derivatives Containing Furan(I)

The furan ring system possesses electron‐rich properties and exhibits various biological activities, which was introduced into diacylhydrazine to create novel leading compounds that may serve as improved pesticides and pharmaceuticals. A series of novel diacylhydrazine derivatives containing a furan ring were synthesized by the reaction of 5‐fluorophenyl‐2‐furoyl chloride with substituted benzoylhydrazide in anhydrous dichloromethane under reflux. The structures of the resultant compounds were confirmed by IR, ¹H NMR, MS and elemental analysis. Insecticidal and anti‐tumor activities of these new compounds were evaluated.     

Furoylation of alkylbenzenes

The acylation of alkylbenzenes with furoyl chloride in the presence of catalytic amounts of FeCl₃ requires a relatively high reaction temperature (150°C) and is accompanied by the elimination of alkyl groups. It is shown by the method of competitive reactions of furoyl and benzoyl chlorides with aromatic compounds that the activity of furoyl chloride is higher when small amounts of the catalyst are present.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1608–1610, December, 1979.Original article submitted November 9, 1978.     

2-(Fur-2-yl)naphtho[2,1-d]oxazole. Synthesis and some transformations

The condensation of 1-hydroxy-2-aminonapnthalene with furoyl chloride in 1-methyl-2-pyrrolidone medium afforded 2-(fur-2-yl)naphtho[2,1-d]oxazole. It was involved in reactions of electrophylic substitution like nitration, bromination, sulfonation, formylation, and acylation. In all cases the substituent enters in position 2 of the furan ring.     

Simple Approach to the Highly Stereoselective Synthesis of trans-1,2-Cyclopropane Derivatives

In the presence of KF·2H2O, furoylmethyltriphenylarsonium bromide （1a） or thienoylmethyltriphenylarsonium bromide （1b） reacted with 2-[（un）substituted benzylidene]malononitrile （2） in chloroform at room temperature to give trans-3,3-dicyano-1-furoyl-2-[（un）substituted phenyl]cyclopropane （3a） or trans-3,3-dicyano-1-thienoyl-2- [（un）substituted phenyl]cyclopropane （3b） respectively in good yield with high stereoselectivity. The structures of product 3 were confirmed by IR, MS, 1^H NMR, 1^H-1^H COSY and microanalysis. The relative configuration of product 3 was determined by 1^H-1^H NOESY technique. The mechanism for the formation of product 3 was also proposed.     

Synthesis of 4-functionalyzed 2,3-bis(diethoxyphosphorylmethyl)furans

Using alkyl 4,5-bis(diethoxyphosphorylmethyl)furan-3-carboxylate as examples, we have demonstrated the possibility of synthesis of a phosphorylated analog of aglycone of the glycoside regulator of cellulose and callose synthesis, bis(phosphorylated) furoyl derivatives of natural amino acids, and phosphorus-containing derivatives of N-furyl-N′-hydroxyethylurea; these compounds are of interest for pharmacology.     

Synthesis and some transformations of 2-(2-furyl)naphtho[1,2-<Emphasis Type="Italic">d</Emphasis>]oxazole

By condensation of 1-amino-2-hydroxynaphthalene with furoyl chloride in 1-methyl-2-pyrrolidone 2-(2-furyl)naphtho[1,2-d]oxazole was synthesized and brought into electrophylic substitution reactions: nitration, bromination, sulfonation, formylation, and acylation. The substituent commonly was introduced into the position 5 of the furan ring, but at the nitration and bromination electrophilic attack was directed both at the furan ring and the naphthalene fragment.     

Synthesis and properties of 2-(2-furyl)-and 2-(2-Thienyl)-1,3-benzoxazoles

Condensation of o-aminophenol with furoyl and thenoyl chlorides in 1-methylpyrrolidin-2-one gave, respectively, 2-(2-furyl)- and 2-(2-thienyl)-1,3-benzoxazoles in which the furan and thiophene rings showed no acidophobic properties. Reactions of 2-(2-furyl)- and 2-(2-thienyl)-1,3-benzoxazoles with electrophilic reagents (acylation, bromination, nitration, and sulfonation) afforded products of hydrogen replacement in both hetaryl and benzene rings, depending on the conditions.