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1.
The corresponding derivatives of 1,3,4-oxadiazoles have been synthesized by the reaction of monohydrazides of 2-aryl-4-methyl-4-cyclohexen-1,1-dicarboxylic acids with triethyl orthoformate or triethyl orthoacetate. 相似文献
2.
E. S. Nikitskaya E. I. Levkoeva V. S. Usovskaya M. V. Rubtsov 《Chemistry of Heterocyclic Compounds》1965,1(2):195-197
7-Hydroxy-3, 9-diazabicyclo[3.3.1]nonane is synthesized, starting from the dimethyl ester of the 4-hydroxypiperidine-2, 6-dicarboxylic acid, by preparing the N-benzyl derivative and cyclizing the latter with benzylamine to the benzylimide of the 1-benzyl-4-hydroxypiperidine-2, 6-dicarboxylic acid. On reduction of the given imide with lithium aluminum hydride and catalytic hydrogenolysis of the benzyl groups, the final 7-hydroxy-3,9-diazabicyclo[3.3.1]nonane is obtained, the three-dimensional structure of which (chair-chair type) is proved by comparison of its methyl derivative with a known compound of demonstrated three-dimensional structure. 相似文献
3.
Thephenolscontainingalkenylunitslarealargegroupofinterestingnaturalproductsexhibitingmanyphysiologicalfunctionssuchasantiflammatory,antibacterialandantioxidativeactivities2.Twonovelacetophenones1and2wererecentlyisolatedfromthefruitsofEvodiamerrillii,asmallfolkmedicinaltreewidelydistributedinTaiwan',andtheaerialpartsofBorroniaromosainAustraliangenusBoroniarespectively'.Theirstructureswereelucidatedas4-(l'-geranyl)-2,6-dihydroxyacet1and4-(l'-farnesyl)-2,6-dihydroxyacetophen2bymeansofspectrosco… 相似文献
4.
2-(6-Aryl-4-methylcyclohex-3-enecarbonyl)-4-ethoxycarbonylpyrazolin-1H-3-ones have been synthesized from 2′-N-(2,2-diethoxycarbonylvinyl)monohydrazides
of 6-aryl-4-methylcyclohex-3-ene-1,1-dicarboxylic acids by boiling in DMF, pyridine, or toluene in the presence of potassium
carbonate. Under analogous conditions, but without potassium carbonate, 2′-N-substituted hydrazides of cyclohexenecarboxylic
acids are obtained.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1007–1011, July, 2005. 相似文献
5.
A heteronuclear compound, K2[Co(Dipc)2]·7H2O (Dipc=pyridine-2,6-dicarboxylic acid) has been synthe- sized and characterized by IR, elemental analysis, and X-ray diffraction. Crystal data: orthorhombic system with space group Pnna and unite cell parameters: a=2.0645(3)nm, b=1.3484(2)nm, c=0.8204(1)nm; V=2.2838(6)nm3, Z=4, Dcald=1.726 g·cm-3, μ=1.193 mm-1, F(000)=1212, Gof=1.045, Δρ=339~-348 e·nm-3, the final R is 0.0295. In the molecule of the complex, Co(Ⅱ) ion is six-coordinate to form a dis-torted octahedron. The N atom and the carboxyl group of pyridine-2,6-dicarboxylic acid are coordinated with the central ions. One of the carboxyl groups of the pyridine-2,6-dicarboxylic acid connect K(Ⅰ) and Co(Ⅱ). The com- pound possesses approximate C2 symmetry. The compounds form a three-dimensional network of infinite length connection with crystal waters, potassium ions and hydrogen bonds. The result of kinetics of thermal decomposition indicated that the compound decomposition takes place in two steps. CCDC: 207078. 相似文献
6.
吡啶-2,6-二甲酸经酯化,肼解得吡啶-2,6-二甲酰肼(2),(2)与芳香醛缩合得到了3个新的酰腙配体:吡啶-2,6-二甲酰肼苯甲醛腙(3a)、吡啶-2,6-二甲酰肼水杨醛腙(3b)和吡啶-2,6-二甲酰肼呋喃甲醛腙(3c),其结构经元素分析、IR、1HNMR和MS进行了确认。制备了吡啶-2,6-二甲酰肼与这三种新型配体的Tb(III)和Eu(III)配合物,并对配合物的溶液态的荧光性质进行了研究。结果表明,吡啶-2,6-二甲酰肼苯甲醛腙(3a)和吡啶-2,6-二甲酰水杨醛腙(3b)作为荧光敏化剂,对Eu3+和Tb3+的荧光敏化性能比吡啶-2,6-二甲酰肼以及大多数吡啶-2,6-二甲酸衍生物要好,是较理想的稀土荧光敏化剂,它们的稀土配合物在分子偶极矩较小的溶剂中荧光强度较强。 相似文献
7.
8.
The dihydrazones, bis(diphenylhydrazones), and bis (2,4-dinitrophenylhydrazones) of adamantanone-2-carboxylic acid, dimethyl adamantane-2,6-dione-1,5-dicarboxylate, and tetramethyl adamantane-2,6-dione-1,3,5,7-tetracarboxylate and the pyrazolones of the corresponding acids were synthesized. It is shown that the methyl esters of adamantane-2,6-dione-1,5-dicarboxylic and -1,3,5,7-tetracarboxylic acids and their hydrazones cannot be converted to adamantane-1,5-dicarboxylic and -1,3,5,7-tetracarboxylic acids under the conditions of the Huang-Minlon and Locke reactions.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 528–531, April, 1982. 相似文献
9.
Z. Tetere D. Zicane I. Ravina M. Petrova E. Gudrinece U. Kalejs 《Chemistry of Heterocyclic Compounds》2002,38(6):677-681
1-(1-Carboxy-2-R-4-methylcyclohex-4-enyl)carbonyl- and 1-(2-R-4-methylcyclohex-4-enyl)carbonyl-3,5-dimethyl(diphenyl)pyrazoles have been obtained from the reaction of monohydrazides of 2-R-methyl-4-cyclohexen-1,1-dicarboxylic acids and hydrazides of 2-R-4-methyl-4-cyclohexen-1-monocarboxylic acids with acetylacetone and dibenzoylmethane. The conditions for the formation of the pyrazoles depend on the nature of the substituents in the hydrazide starting materials and the structure of the 1,3-diketone used. 相似文献
10.
11.
Esters of substituted quinoxaline-2,3-dicarboxylic acids (Table 1), which are intermediates in the synthesis of heterocyclic analogs of phthalocyanin [2,3], were synthesized by the condensation of aromatic o-diamines with esters of diketosuccinic acid [1]. A similar condensation is described only in the case of a heterocyclic o-diamine — 2,3-diaminoquinoxaline [4], 2,3-Dihydroxyquinoxaline was isolated instead of the expected ester of quinoxalinedicarboxylic acid in [5] by the reaction of o-phenylenediamine with diethyl diketosuccinate; however, we were able to obtain the normal condensation products by using pure starting ester.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 280–281, February, 1971. 相似文献
12.
The optimum route for the synthesis of methyl esters of N-[(4-substituted amino)-5-cyano-2-methylthiopyrimidin-6-yl]amino acids (which are starting materials for preparing the methyl esters of the corresponding 5-amino-4-(substituted amino)pyrrolo[2,3-d]pyrimidine-6-carboxylic acids) is via subsequent reactions of 4,6-dichloro-2-methylthiopyrimidine-5-carbonitrile with amines and methyl glycinate. In some examples, the reaction of methyl N-(4-chloro-2-methylthio-6-pyrimidinyl)aminoacetate with amines occurs to give the corresponding acid amides. The previously unknown synthesized derivatives of pyrimidin-6-yl amino acids and 4,5-diaminopyrrolo[2,3-d]pyrimidine- 6-carboxylic acids possess fungicidal properties.Vilnius University, Vilnius 2006, Lithuania. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No 7, pp. 955–961, July, 2000. 相似文献
13.
Substituted 5-oxa-6-azaspiro[2.4]heptane-1,2-dicarboxylic acid esters synthesized by reaction of nitrones with dimethyl 3-methylidenecyclopropane-1,2-dicarboxylate were reduced with lithium tetrahydridoaluminate to the corresponding bis(hydroxymethyl)cyclopropanes. Alkaline hydrolysis of the title compounds gave substituted cyclopropane-1,2-dicarboxylic acids. In both cases, the 5-oxa-6-azaspiro[2.4]heptane fragment remained intact. 相似文献
14.
15.
Al Majid AM Islam MS Al-Othman ZA Al-Salhoob AF Barakat A 《Molecules (Basel, Switzerland)》2012,17(5):5550-5563
The hemilabile chiral C2 symmetrical bidentate substituted amide ligands (1R,2R)-5(a-d) and (1S,2S)-6(a-d) were synthesized in quantitative yield from (1R,2R)-(+)-3-methylenecyclo-propane-1,2-dicarboxylic acid (1R,2R)-3 and (1S,2S)-(-)-3-methylene-cyclopropane-1,2-dicarboxylic acid (1S,2S)-3, in two steps, respectively. The chiral Feist's acids (1R,2R)-3 and (1S,2S)-3 were obtained in good isomeric purity by resolution of trans-(±)-3-methylene-cyclopropane-1,2-dicarboxylic acid from an 8:2 mixture of tert-butanol and water, using (R)-(+)-α-methylbenzyl amine as a chiral reagent. This process is reproducible on a large scale. All these new synthesized chiral ligands were characterized by 1H-NMR, 13C-NMR, IR, and mass spectrometry, as well as elemental analysis and their specific rotations were measured. These new classes of C2 symmetric chiral bisamide ligands could be of special interest in asymmetric transformations. 相似文献
16.
Oxidation of the corresponding 3, 6-diacetylcarbazoles gives 9-n-butyl- and 9-isoamylcarbazole-3, 6-dicarboxylic acids. 9-Alkylcarbazole-3, 6-dicarboxylic acids are converted to acid chlorides, which are esterified with allyl alcohol without being isolated pure. Allyl 9-ethyl-, 9-n-butyl- and 9-isoamylcarbazole-3, 6-dicarboxylates are synthesized. The ability of these esters to polymerize and to undergo copolymerization with methyl mercaptan is demonstrated with the example of diallyl 9-ethylcarbazole-3, 6-dicarboxylate.For Part XII see [8]. 相似文献
17.
WANG Zhi-Cai ZHENG Qi-Huang GAO BiDepartment of Chemistry Zhongshan University Guangzhou Guangdon ChinaFAN Shi-YanInstrumentation Analysis Research Centre Zhongshan University Guangzhou Guangdon China 《中国化学》1994,12(4):372-377
Two key intermediates of cembranolides- (2E,6E,10E)-3,7,11,15-tetramethyl-9-phenylsulfonyl-2,6,10,14-tetraen-1-hexadecanol (1) and (2E,6E,10E,14E)-2,6,10,14-tetramethyl-8-phenylsulfonyl-2,6,10,14-tetraen-1,16-hexadecanediol (2) were synthesized starting from geraniol and linalool and some improved synthetic methods were used. 相似文献
18.
Z. Tetere D. Zicane I. Ravina M. Petrova E. Gudriniece 《Chemistry of Heterocyclic Compounds》2003,39(9):1178-1181
Monohydrazides of 2-aryl-4-methyl-4-cyclohexene-1,1-dicarboxylic acids react with 2-thiophene-, 3-pyridine-, and 4-pyridinecarbaldehydes to form the corresponding acylhydrazones of hydrazides of mono- or dicarboxylic acids of the cyclohexene series depending on the temperature. 相似文献
19.
The reaction of ethyl 2-(dimethylamino)methylene-3-oxobutanoate with diethyl oxalate in the presence of sodium hydride in THF gave diethyl 4-oxo-4H-pyran-2,5-dicarboxylate, from which 4-oxo-4H-pyran-2,5-dicarboxylic and 4-oxo-1-phenyl-1,4-dihydropyridine-2,5-dicarboxylic acids and their derivatives were obtained in good yields. 相似文献
20.
Syntheses of 2- or 6-Substituted Chromones and Chromone Ring-opening Reaction in Polyphosphoric Acid
HEXun-gui YOUQi-dong LIZhi-yu 《高等学校化学研究》2004,20(3):299-304
In an attempt to find new antitumor agents, a novel class of chromone compounds with a benzimidazoleor a benzoxazole ring in positions 2 or 6 were synthesized νia condensation in polyphosphoric acid(PPA) byusing chromone acids as the starting materials. During the preparation process, it was found that PPA couldcleave the chromone ring to produce a ring-opening compound(6). The molar ratio of the chromone com-pound (5) to the ring-opening compound (6) varied with the change of reaction temperature and time. Basedon MTT protocol, the antitumor activity of each of the compounds obtained was evaluated against three hu-man cancer cell lines: KB(oral epidermal), A2780(ovary) and Be17402 (liver). The IC50 varied from 54.7μmol/L to more than 180 μmol/L. 相似文献