| N-(2-氯乙基)-N'-2-(O~6-苄基-9-鸟嘌呤基)乙基-N-亚硝基脲的合成 |
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| 引用本文： | 王雅朦,任婷,宋秀庆,赵丽娇,钟儒刚.N-(2-氯乙基)-N'-2-(O~6-苄基-9-鸟嘌呤基)乙基-N-亚硝基脲的合成[J].合成化学,2016(3):215-218. |
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| 作者姓名： | 王雅朦 任婷 宋秀庆 赵丽娇 钟儒刚 |
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| 作者单位： | 北京工业大学生命科学与生物工程学院环境与病毒肿瘤学北京市重点实验室,北京,100124 |
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| 基金项目： | 国家自然科学基金资助项目(21277001) |
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| 摘 要： | 以O~6-苄基鸟嘌呤为原料,经取代反应和盖布瑞尔反应制得N9-(2-胺基)乙基-O6-苄基鸟嘌呤(4);4与异氰酸酯经取代反应和经亚硝化反应合成了N-(2-氯乙基)-N'-2-(O6-苄基-9-鸟嘌呤基)乙基-N-亚硝基脲(6)。4和6为新化合物,其结构经UV-Vis,1H NMR,13C NMR,IR和HR-ESI-MS表征。
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| 关 键 词： | O6-苄基鸟嘌呤 N-(2-氯乙基)-N′-2-( O6-苄基-9-鸟嘌呤基)乙基-N-亚硝基脲 联合亚硝基脲 合成 AGT抑制剂 |
Synthesis of N-(2-chloroethyl)-N′-2-(O6-benzyl-9-guanineyl) ethyl-N-nitrosourea |
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| Abstract: | N9-(2-amino)ethyl-O6-benzylguanine(4) was obtained through substitution and Gabriel re-action, using O6-benzylguanine as the starting material.N-( 2-chloroethyl )-N′-2-( O6-benzyl-9-gua-nine) ethyl-N-nitrosourea(6) was synthesized by isocyanate substitution of 4, followed by a nitrosation reaction.4 and 6 were new compounds.And their structures were characterized by UV-Vis, 1 H NMR, 13 C NMR, IR and HR-ESI-MS. |
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| Keywords: | O6-benzylguanine N-( 2-chloroethyl )-N′-2-( O6-benzyl-9-guanine ) ethyl-N-nitrosourea combi-nitrosourea synthesis AGT inhibitor |
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