重离子束适形放射治疗技术

重离子束适形放射治疗技术主要包括束流配送系统和治疗计划系统等 .前者是实现重离子束适形放射治疗的硬件设施 ,后者为适形治疗的软件支撑系统 ,两者缺一不可 .鉴于重离子束与物质相互作用在物理学及生物学效应上表现出的特殊性,重离子束治癌中特别引入了面向生物学效应的适形治疗和束流的正电子断层在线监控技术. The conformal radiotherapy techniques mainly include the two systems that are beam delivery and treatment planning. The formal is the hardware basis while the later is the software supplement for heavy ion conformal therapy, they are dependent on each other to realize the cancer conformal therapy with heavy ion beam. Because of the specificities of interaction between heavy ion and target on both physics and biological effects, the heavy ion cancer therapy especially involves...     

栅扫描重离子束治癌束流配送系统对运动靶区的适形放疗(Ⅱ)可行性实验

在栅扫描束流配送系统下, 进行了重离子束对运动靶体进行适形照射的可行性实验研究. 利用实时修正束流扫描参数的方法, 使得束流追踪靶体在横向上的运动; 在纵向上利用一个机械驱动的束流降能装置(称深度扫描器)迅速调节束流 能量, 使得重离子束高剂量的Bragg峰区落在运动靶体需治疗的断层之上. 实验结果表明: 栅扫描器主动补偿靶体横向运动及深度扫描器补偿靶体纵向运动是可行的.     

Proposal for muon and white neutron sources at CSNS

The China Spallation Neutron Source （CSNS） is a large scientific facility with the main purpose of serving multidisciplinary research on material characterization using neutron scattering techniques. The accelerator system is to provide a proton beam of 120 kW with a repetition rate of 25 Hz initially （CSNSⅠ）, progressively upgradeable to 240 kW （CSNS-Ⅱ） and 500 kW （CSNS-Ⅱ＇）. In addition to serving as a driving source for the spallation target, the proton beam can be exploited for serving additional functions both in fundamental and applied research. The expanded scientific application based on pulsed muons and fast neutrons is especially attractive in the overall consideration of CSNS upgrade options. A second target station that houses a muon-generating target and a fast-neutron-generating target in tandem, intercepting and removing a small part of the proton beam for the spallation target, is proposed. The muon and white neutron sources are operated principally in parasitic mode, leaving the main part of the beam directed to the spallation target. However, it is also possible to deliver the proton beam to the second target station in a dedicated mode for some special applications. Within the dual target configuration, the thin muon target placed upstream of the fast-neutron target will consume only about 5% of the beam traversed; the majority of the beam is used for fast-neutron production. A proton beam with a beam power of about 60 kW, an energy of 1.6 GeV and a repetition rate of 12.5 Hz will make the muon source and the white neutron source very attractive to multidisciplinary researchers.     

HIRFL-CSR实验环中束流损失机制及寿命研究

分析了在储存环中回旋的离子束与残余气体分子、 内靶和冷却电子束相互作用时的损失机制及相应的束流寿命, 针对兰州重离子加速器冷却储存环实验环内靶模式, 计算了50—500 MeV/u 12C6+, 36Ar18+, 132Xe54+和 238U92+等束流在各种损失机制影响下所对应的束流寿命和总的束流寿命。 结果表明: 影响束流寿命的主要因素是与内靶分子（原子）之间的电荷交换及与冷却电子束之间的辐射复合; 对于重离子束 132Xe54+和 238U92+, 与冷却电子束之间的辐射复合是影响其储存寿命的主要因素。The loss mechanism and lifetime of ion beams in collisions with residual gas, internal target and electrons in e cooler in heavy ion cooler storage rings were studied. The partial beam lifetimes resulting from various loss mechanisms and the total beam lifetimes of 50—500 MeV/u12C6+, 36Ar18+, 132Xe54+ and 238U92+ stored in the experimental ring of the Cooler Storage Ring at the Heavy Ion Research Facility in Lanzhou (HIRFL CSR) were calculated. The calculations indicate that the charge exchange process between ion beams and the internal target, as well as the radiative recombination process with the electrons in e cooler restrict the beam lifetime considerably. For heavy ion beams such as 132Xe54+ and 238U92+, the radiative recombination is the dominant loss mechanism     

Proposal for muon and white neutron sources at CSNS

The China Spallation Neutron Source (CSNS) is a large scientific facility with the main purpose of serving multidisciplinary research on material characterization using neutron scattering techniques. The accelerator system is to provide a proton beam of 120 kW with a repetition rate of 25 Hz initially (CSNSⅠ), progressively upgradeable to 240 kW (CSNS-Ⅱ) and 500 kW (CSNS-Ⅱ'). In addition to serving as a driving source for the spallation target, the proton beam can be exploited for serving additional functions both in fundamental and applied research. The expanded scientific application based on pulsed muons and fast neutrons is especially attractive in the overall consideration of CSNS upgrade options. A second target station that houses a muon-generating target and a fast-neutron-generating target in tandem, intercepting and removing a small part of the proton beam for the spallation target, is proposed. The muon and white neutron sources are operated principally in parasitic mode, leaving the main part of the beam directed to the spallation target. However, it is also possible to deliver the proton beam to the second target station in a dedicated mode for some special applications. Within the dual target configuration, the thin muon target placed upstream of the fast-neutron target will consume only about 5% of the beam traversed; the majority of the beam is used for fast-neutron production. A proton beam with a beam power of about 60 kW, an energy of 1.6 GeV and a repetition rate of 12.5 Hz will make the muon source and the white neutron source very attractive to multidisciplinary researchers.     

ADS注入器II的5 MeV高能传输线的设计与搭建

ADS先导专项的注入器Ⅱ计划在将质子束通过一个Cryomodule加速到5 MeV后,进行10 mA连续束流的调试,以验证ADS低能段的强流超导直线加速器技术。为了将50 kW的束流功率沉积到束流垃圾站,需要搭建一条高能束流传输线,从超导段开始传输束流。采用两套三组合四极透镜控制束流包络及垃圾站的束流尺寸,利用诊断真空室进行水平和垂直发射度的测量。为避免束流产生的真空管道损伤,该传输线必须确保束流无损失地传输到垃圾站。A CW 10 mA,5 MeV beam commissioning of CADS Injector Ⅱ is planed recently to test the high power superconduction linac techniques.To transport 50 kW beam from linac to the beam dump,a high energy beam line (HEBT) line is designed and setup.Two Triplet are used to control the beam size along HEBT and at the beam dump.One diagnostics box is used for horizontal and vertical emittance measurement.To avoid damages to the vacuum pipe,beam should be transported to the beam dump without losses.The details of the HEBT design will be described in the paper.     

RIBLL次级束流强度的提高

为了提高兰州重离子加速器放射性次级束流线的束流强度,在现有的输运线基础上 ,设计了一个由一组超导螺线管和一个产生靶组成的次级束流增强系统.简要介绍了这个系统的束流光学设计原理和系统的初步设计.In order to meet the meeds of nuclear physic research, the beam intensity of RIBLL (Radioactivy Ion Beam Line in Lanzhou) should be improued. This can be carried out by two ways: increasing the primary beam intensity or improuing the transmission of the beam line. A system consisting of three superconducting solenoids and a new target frame is designed.     

Particle filter based visual tracking with multi-cue adaptive fusion

To improve the robustness of visual tracking in complex environments such as: cluttered backgrounds, partial occlusions, similar distraction and pose variations, a novel tracking method based on adaptive fusion and particle filter is proposed in this paper. In this method, the image color and shape cues are adaptively fused to represent the target observation; fuzzy logic is applied to dynamically adjust each cue weight according to its associated reliability in the past frame; particle filter is adopted to deal with non-linear and non-Gaussian problems in visual tracking. The method is demonstrated to be robust to illumination changes, pose variations, partial occlusions, cluttered backgrounds and camera motion for a test image sequence.     

Particle filter based visual tracking with multi-cue adaptive fusion

To improve the robustness of visual tracking in complex environments such as: cluttered backgrounds, partial occlusions, similar distraction and pose variations, a novel tracking method based on adaptive fusion and particle filter is proposed in this paper. In this method, the image color and shape cues are adaptively fused to represent the target observation; fuzzy logic is applied to dynamically adjust each cue weight according to its associated reliability in the past frame; particle filter is adopted to deal with non-linear and non-Gaussian problems in visual tracking. The method is demonstrated to be robust to illumination changes, pose variations, partial occlusions, cluttered backgrounds and camera motion for a test image sequence.     

Robust visual tracking based on multi-cue integration

Traditional color-based mean shift tracking algorithm is unable to accurately track the object. To address this problem, we present an improved tracking algorithm. The improved tracker integrates the color and motion cues which characterize the appearance and motion information of the object, respectively. These two visual cues can complement each other and make for more precise target localization. Experiments show that the proposed tracking algorithm has better performance than the traditional mean shift tracker.     

栅扫描重离子束治癌束流配送系统对运动靶区的适形放疗(Ⅰ)模拟计算

从理论上研究了在主动型栅扫描束流配送系统下,靶体运动对靶区剂量均匀性以及重离子治疗适形程度的影响.模拟计算了在实验测量得到的脉冲束流照射下,栅扫描系统引导束流对运动靶体实施照射后,靶体运动模式与靶区各等能量断层剂量分布均匀性的关系.由这些模拟计算结果,得到了一些针对运动靶体提高靶区剂量分布均匀性的策略.模拟计算提供了一种评估运动靶体上剂量分布的有效手段,其结果及内涵为今后该方向上的可行性实验研究奠定了坚实的基础.     

栅扫描重离子束治癌束流配送系统对运动靶区的适形放疗冰(Ⅰ)模拟计算

从理论上研究了在主动型栅扫描束流配送系统下,靶体运动对靶区剂量均匀性以及重离子治疗适形程度的影响.模拟计算了在实验测量得到的脉冲束流照射下,栅扫描系统引导束流对运动靶体实施照射后,靶体运动模式与靶区各等能量断层剂量分布均匀性的关系.由这些模拟计算结果,得到了一些针对运动靶体提高靶区剂量分布均匀性的策略.模拟计算提供了一种评估运动靶体上剂量分布的有效手段,其结果及内涵为今后该方向上的可行性实验研究奠定了坚实的基础.     

低能离子束横向发射度的测量及分析

The transverse emittance of an ion beam describes its transverse size as the particles are transported from a source to a target.It allows for predicting beam losses in limiting apertures and the beam focus size at the target.Various definitions and issues are discussed.The most common and emerging measuring techniques are presented,including their advantages.Several methods of emittance data analysis,their accuracy and trustworthiness,are discussed.     

Formation,Dynamics, and Characterization of Nanostructures by Ion Beam Irradiation

Ion beam irradiation is a potential tool for phase formation and material modification as a non-equilibrium technique. Localized rise in temperature and ultra fast (～10^?12 s) dissipations of impinging energy make it an attractive tool for metastable phase formation. As a matter of fact, a major component of materials science is dominated by ion beam methods, either for synthesis of materials or for its characterization. The synthesis of nanostructures, and their modification by ion beam technique will be discussed in this review article. Formation of nanostructures using ion beam technique will be discussed first. Depending on species (e.g., mass and charge state) and energy range, there are various modes for an energetic ion to dissipate its energy. The role of the electron will also be covered in this article as a basic principle of its interaction with matter, which is same as for an ion. By using a simple reactive ion beam or electron induced deposition, a secondary phase can be nucleated by ion beam mixing techniques, either by using inert gas irradiation or reactive gas implantation on any desired substrate. Nucleation of secondary phase can also be executed by electron irradiation and direct implantation of either negative or positive ions. Post implantation annealing processes are required for the complete growth of clusters formed in most of these ion irradiation techniques. Implantation processes being inherently a non-equilibrium technique, defects always have a role to play in phase formation, amorphization, and beyond (blister formation). When implanted with large energy, even electrons, one of the lightest charged particles, also manifest these properties. Electronic and nuclear energy losses of the impinging charged particle play a crucial role in material modification. Doping a nanocluster, however, is still a controversial topic. Some light will be shed on this topic with a discussion of focused ion beam.     

HIRFL辐照终端照射野均匀度与离子通量的关系

采用固体核径迹探测器聚碳酸脂膜,测定了兰州重离子研究装置提供的55MeV/u40Ar和80MeV/u20Ne离子束经辐照终端束流均匀化扫描装置后照射野均匀度与离子通量之间的关系.结果表明:对于40Ar和20Ne离子束,离子通量小于1×106和2×107ions/cm2时,横向照射野均匀度缓Ne离子束照射慢增加;当离子通量分别介于1×106—1×107和2×107—1×108ions/cm2时,40Ar和20野均匀度逐渐增加;离子通量达到1×107和1×108ions/cm2时,40Ar和20Ne离子束照射野均匀度分别约为58%和61%.从而说明,辐照终端束流扫描装置对束流的均匀化程度目前并不能满足辐照生物效应、辐射育种和重离子治癌等研究工作的需要,须对其性能做进一步的提高. Using 55 MeV/u 40Ar and 80 MeV/u20Ne ion beams delivered by the Heavy Ion Research Facility at Lanzhou (HIRFL), the relationships between the irradiation homogeneities in irradiation fields generated by the beam scanning device located at the irradiation terminal of the HIRFL and ion fluence were measured respectively with 100 μm polycarbonate films by means of nuclear track detection. The results show that the homogeneity increases when the ion fluence are lower than ........     

基于自适应背景的目标跟踪算法研究

随着现在的社会发展以及经济进步,我国的科学技术方面发展迅速,特别是在技术监控方面更是突飞猛进。为了更好的对目标遮挡影响进行降低,我国在这方面主要依据自适应的技术发展背景下提出目标跟踪计算法,用来完善我国的监督控制技术。这种计算方式第一是根据对观察目标的基本外观形态进行的鉴定与跟踪,将其自身的运动量进行平均计算;其次是根据时空的运行方向与特征进行跟踪目标的计算,建立比较完善整体的运行模型,再根据这个运动模型以及整体的状态对监督目标进行检测与控制,这期间就会形成一种遮挡掩膜。对于掩膜是一种将程序数据等绘制成光刻板,在程序使用期间非常可靠,并且制造成本比较低,使用方便;最后是在不同的使用情况下将不同参数进行收集,自动的适应运动模型的运行。针对这种计算方式的实验主要是利用两种在国际上经常使用的CAVIAR、York数据进行测试,并且根据这两种数据对测试的精准度与多重目标跟踪等进行评定,检测跟踪的整体性能。通过多方面的研究表明这种方式的跟踪的性能非常好,并且还能很好的将跟踪目标的鲁棒性进行遮挡。     

基于运动检测的多车辆跟踪方法研究

针对交通监控场景中多目标粘连造成跟踪上的困难和前后两帧车辆关联困难,提出了区域运动相似性分割方法和相似度关联矩阵的解决方案;在运动目标检测过程中, 首先使用背景差分法提取运动区域,经过消除缺口、空洞和分离等处理,在运动区域所在范围内进行块匹配搜索和局部光流计算区域运动矢量,然后使用模糊聚类方法对运动矢量区域融合,完整的分割出粘连运动目标;在目标跟踪部分,目标跟踪建立在目标关联的基础上,提出建立连续两帧目标间距离和局部二元模式相似度关联矩阵的方法进行运动目标标定,从而实现多目标关联;使用公共视频库的图像序列进行测试,所提算法都能实现连续的跟踪和准确的运动目标分割,且处理速度快,表明了算法具有鲁棒性和适用性。     

强脉冲离子束辐照薄金属靶的热力学过程研究

在回顾和总结现有强脉冲离子束诊断技术和能量沉积模型的基础上, 结合红外成像诊断分析, 基于能量平衡, 提出了强脉冲离子束在固体靶中功率密度分布模型, 并采用蒙特卡罗方法对其进行计算. 以该功率密度模型作为源项, 使用有限元分析方法模拟强脉冲离子束入射100 μm不锈钢靶后内部温度场在毫秒时间范围内的分布和演化. 结果显示, 在微秒时间范围内, 热场以存在于近表面区域数倍于离子射程范围内的冲击热场为主要特征; 而在毫秒时间范围内, 靶的前后表面(纵向)已达到温度平衡, 且靶后表面温度场和入射前表面的离子束横截面能量密度具有空间分布的相似性. 这证明了, 在采用具有毫秒响应速度的红外拍摄系统的情况下, 背面红外诊断技术可以实现以较高的精度对强脉冲离子束横截面的能量分布进行诊断和分析.     

Active spot-scanning test with heavy ions at HIRFL-CSR

An active spot beam delivery system for heavy ion therapy has been developed based on the Cooling Storage Ring at HIRFL-CSR, where the pencil carbon-ion beams were scanned within a target volume transversely by a pair of orthogonal (horizontal and vertical) dipole magnets to paint the slices of the target volume and longitudinally by active energy variation of the synchrotron slice by slice. The unique techniques such as dose shaping via active energy variation and magnetic deflection constitute a promising three-dimensional conformal even intensity-modulated radiotherapy with heavy ions at HIRFL-CSR. In this paper, the verification of active energy variation and the calibration of steerable beam deflection are shown, as the basic functionality components of the active spot-scanning system. Additionally, based on the capability of creating homogeneous irradiation fields with steerable pencil beams, a radiobiological experiment like cell survival measurement has been performed aiming at comparison of the radiobiological effects under active and passive beam deliveries.