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以聚乙烯醇(PVA)-戊二醛(GA)体系作为研究对象, 系统地研究了分子内环化对凝胶体系的影响, 为水凝胶体系的网络结构评价奠定了一定的实验基础. 相似文献
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Aeysha Sultan 《合成通讯》2014,44(3):417-423
An efficient free radical–mediated intramolecular cyclization strategy has been developed for the synthesis of 3-aryl-5-chloroindan-1-ones. Variously substituted 2,4-dichloroenones afforded 3-aryl-5-chloroindan-1-ones in quantitative yields upon intramolecular cyclization under free radical conditions. 相似文献
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A novel protocol for intramolecular ketyl-olefin radical cyclization with low-valent titanium reagent is outlined. It allows the formation of the benzopyran nucleus from ortho-allyloxy propiophenones as the sole product in moderate yields via intramolecular radical cyclization. 相似文献
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Em. O. Chukhadzhyan H. R. Gevorgyan K. G. Shahkhatuni El. O. Chukhadzhyan L. V. Ayrapetyan A. A. Khachatryan 《Russian Journal of Organic Chemistry》2018,54(4):517-525
The review discusses intramolecular cyclization of ammonium salts containing a 4-hydroxybut-2- yn-1-yl group in combination with various π4-fragments, as well as mechanisms of cyclization and intramolecular recyclization of the resulting 4-(hydroxymethyl)dihydroisoindolium salts and their fused analogs. The process is accompanied by neither ring expansion nor contraction, and a pharmacophoric 1,3-dihydrofuran ring is formed instead of dihydroisoindolium fragment. The effects of electronic and structural factors on the intramolecular cyclization and recyclization processes are considered. 相似文献
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F. Z. Galin I. M. Sakhautdinov S. N. Lakeev V. A. Egorov A. A. Fatykhov I. O. Maidanova 《Russian Chemical Bulletin》2005,54(12):2867-2872
Keto-stabilized sulfur mono-and bisylides were obtained from N-phthalylglutamic acid and their intramolecular cyclization was studied. The intramolecular cyclization of the ylide obtained
at the α-carboxy group gave a product of the pyrrolizidinedione structure; bisylide yielded a cycloheptene derivative as the
result of intramolecular recombination of intermediate dicarbene. The ylide obtained at the γ-carboxy group underwent no cyclization,
giving methylthio ketone and oxo benzoate.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2771–2776, December, 2005. 相似文献
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M. Damodiran 《Tetrahedron letters》2009,50(39):5474-5478
The intramolecular cyclization of amidoalkyl naphthols by Vilsmeier reagent produced 1,3-oxazines. The Vilsmeier reagent (chloromethylenedimethylammonium chloride) has been used as an efficient and cheap acid activator for the one-step synthesis of oxazine derivatives. A mechanism involving sequential haloformylation and intramolecular nucleophilic cyclization is proposed. 相似文献
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The intramolecular cyclization reactions of tri-1-hex-5-enyl Group III derivatives and of 1-hex-5-enyllithium have been investigated and it is proposed that the reactions may be depicted as internal addition across the terminal double bonds of the alkenyl species. The cyclization reaction proceeds more readily for the 1-hex-5-enyl derivatives than for any other chain length and is dependent on temperature, concentration and solvent. 1H NMR data and cryoscopic molecular weight data are presented for several diisobutyialkenyl- and diisobutylalkyl-aluminum derivatives. These data have been interpreted in terms of a direct intramolecular interaction between the metal center and the π-electron system of the olefinic site. The intramolecular cyclization reactions for the 1-hept-6-enyl, 1-oct-7-enyl- and 1-undec-10-enylaluminum derivatives also were investigated and it was found that cyclization occurred only for the 1-hept-6-enyl derivative. 相似文献
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[reaction: see text] A mild, efficient, one-pot protocol for the cyclization of nitro-aryl substrates using SnCl(2) has been described. The mechanistic course of the reaction suggests the involvement of a hydroxylamine intermediate leading to an intramolecular cyclization via N-N bond formation. The versatility of the methodology has been demonstrated by using two nitro-aryl substrates derived from dihydroisoquinolines and dihydro-beta-carbolines. The intramolecular cyclization led to the formation of indazoles in high yields and purities. 相似文献
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Liu X Xin X Xiang D Zhang R Kumar S Zhou F Dong D 《Organic & biomolecular chemistry》2012,10(29):5643-5646
A facile and efficient synthesis of substituted quinolin-2(1H)-ones is developed via intramolecular cyclization of penta-2,4-dienamides mediated by concentrated H(2)SO(4) (98%), and a mechanism involving the formation of a dicationic superelectrophile, and subsequent intramolecular nucleophilic cyclization reactions is proposed. 相似文献
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E. O. Chukhajian L. V. Ayrapetyan El. O. Chukhajian H. A. Panosyan 《Chemistry of Heterocyclic Compounds》2010,46(2):151-157
Dialkyl(4-hydroxybutyn-2-yl)[3-(p-tolyl)propyn-2-yl]ammonium chlorides undergo a diene synthesis type intramolecular cyclization
in aqueous base medium to give 2,2-dialkyl-4-hydroxymethyl-6-methyl-benzo[f]isoindolinium chlorides. Under conditions of aqueous
base fission intramolecular cyclization of the latter gives 4-dialkylaminomethyl-8-methyl-1,3-dihydronaphtho[1,2-c]furans. 相似文献
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用高分子反应统计理论研究了硅酸聚合反应.利用三甲基硅烷化-气相色谱法跟踪测定了聚合反应过程中各低聚态硅酸的含量变化,得到了分子数量分数分布.该分布符合含有内环化因子校正的A1型缩聚反应统计理论,内环化反应是硅酸聚合反应的重要特征. 相似文献
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Tokutaro Ogata Misae Doe Aya Matsubara Eri Torii Chiaki Nishiura Arisa Nishiuchi Yusuke Kobayashi Tetsutaro Kimachi 《Tetrahedron》2014
The oxidative intramolecular cyclization of 3-hydroxyalkyl-1,2,4-trimethoxynaphthalenes was investigated. A series of 1,2-naphthoquinone fused cyclic ethers were synthesized directly from 3-hydroxyalkyl-1,2,4-trimethoxynaphthalenes by exposure to diammonium cerium (IV) nitrate. To understand the reaction mechanism, the intramolecular cyclization of 3-hydroxyalkyl-naphthoquinones that were formed as reaction intermediates was also examined. The results suggested that the reaction proceeds by a stepwise oxidation–cyclization mechanism. Using this methodology, five-step synthesis of rhinacanthone was achieved with high yield. 相似文献
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New chiral aminoamidoximes were prepared from (L)-proline, (L)-alanine, and (L)-isoleucine by treatment of the corresponding aminonitriles with hydroxylamine in the presence of triethylamine. The intramolecular cyclization with α-bromoacid chlorides and aldehydes was investigated to give new 1,2,4-oxadiazin-6-ones and 1,2,4-oxadiazoles, respectively. These compounds were likely to undergo an intermolecular cyclization through oxygen and nitrogen. However, intramolecular cyclization through two nitrogens did not occur even after changing reaction conditions. 相似文献
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Mitsuaki Yamashita Kazunori UedaKoichi Sakaguchi Akira Iida 《Tetrahedron letters》2011,52(36):4665-4670
A mild strategy for constructing indolequinone motifs is described on the basis of the Sonogashira reaction and a copper-catalyzed intramolecular cyclization cascade reaction. The first step involves the palladium- and copper-catalyzed reaction between halogenated naphthoquinone and terminal acetylene to generate a coupling product, which then reacts in a copper-catalyzed intramolecular cyclization with the nitrogen functional group adjacent to the carbon-carbon triple bond. 相似文献
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Jing Lyu Yongsheng Gao Zidan Zhang Udo Greiser Hongyun Tai Wenxin Wang 《中国科学:化学(英文版)》2018,61(3):319-327
The conventional free radical polymerization (FRP) of multivinyl monomers (MVMs) inevitably leads to gelation even at low monomer conversion resulting in difficulties to control and monitor the reaction process. Flory and Stockmayer (F-S theory) studied it based on two fundamental assumptions: (1) independent and equivalent vinyl groups; (2) no intramolecular cyclization. However, until now its applicability to FRP of MVMs (especially regarding the extent of intramolecular cyclization) is still controversial. In this paper, Monte Carlo simulations are used to study FRP of divinyl monomers by two kinetic models: with/without cyclization models. The results of the simulations are compared with the calculated gel points based on F-S theory and the experimental data. It is found that the intramolecular cyclization has a negligible impact on the polymerization process and the gel point before gelation, which are in agreement with the prediction by F-S theory, but the effect becomes significant above the gel points. 相似文献
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Click Chemistry, a modular, rapid, and one of the most reliable tool for the regioselective 1,2,3-triazole forming [3+2] reaction of organic azide and terimal alkyne is widely explored in various emerging domains of research ranging from chemical biology to catalysis and medicinal chemistry to material science. This regioselective reaction from a diverse range of azido-alkyne scaffolds has been well performed in both intermolecular as well as intramolecular fashions. In comparison to the intermolecular metal (Cu/Ru/Ni) variant of ‘Click Chemistry’, the intramolecular click tool is little addressed. The intramolecular click chemistry is exemplified as a mordern tool of cyclization which involves metal-catalyzed (CuAAC/RuAAC) cyclization, organo-catalyzed cyclization, and thermal-induced topochemical reaction. Thus, we report herein the recent approaches on intramolecular azide-alkyne cycloaddition ‘Click Chemistry‘ with their wide-spread emerging applications in the developement of a diverse range of molecules including fused-heterocycles, well-defined peptidomemics, and macrocyclic architectures of various notable features. 相似文献
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Hiromu Aoyama Michiro Ohnota Masami Sakamoto Yoshimori Omote 《Tetrahedron letters》1984,25(31):3327-3330
N-Akyl and N,N-Dialkylimidazolidinetriones undergo intramolecular hydrogen abstraction on irradiation to give elimination, intramolecular disproportionation, and cyclization products. 相似文献
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Hamed E. O. Assy M. G. Shalaby A. M. Sayed R. E. 《Russian Journal of Organic Chemistry》2020,56(11):2005-2013
Russian Journal of Organic Chemistry - The intermolecular cyclization of N-benzyl-2-cyanoacetamide with carbon disulfide followed by intramolecular cyclization gave thioxothiazinone 3. This... 相似文献