共查询到20条相似文献,搜索用时 265 毫秒
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温度和时间对有机合成反应影响的探讨 总被引:1,自引:0,他引:1
根据物理化学和有机合成原理,从动力学、热力学、反应机理及溶解度等各方面详细分析了反应温度和反应时间对有机合成反应的影响。通过这些分析,可以让同学们更好地在合成反应课程的学习中掌握和分析反应温度和反应时间对反应的影响。 相似文献
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微波在分析化学及有机合成中的应用 总被引:13,自引:0,他引:13
综述了近10年来微波技术在分析化学和有机合成中的应用,着重介绍了微波消解在分析化学和微波辐射在有机合成反应中的应用进展。 相似文献
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由徐家业主编、西北工业大学出版社出版(1997)的<有机合成化学及近代技术>与流行的同类书籍通常偏重于介绍有机合成反应或各类有机化合物的合成方法不同.该书在按化合物的分子骨架构成,和官能团的变换为纲简要地介绍有机合成反应的同时,较全面的介绍了各种近代有机合成方法和技术.包括有机合成设计、有机电化学合成、相转移催化技术、固相合成方法和干法合成等.除了通常的加热促进反应之外,还介绍了光促反应、微波促进反应和声波促进反应,以及生物催化剂的应用和仿生合成法等,展示了有机合成的新面貌.针对有机合成的实用性,还特意编写了"有机合成的化工过程开发"一章,是一本别具风格的有机化学参考书. 相似文献
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The major progress in organic synthesis since 2005 is briefly surveyed in two parts. The first part deals with some of the
most impressive advances in the synthetic methodology, which includes: (1) metal-mediated synthetic reactions, with an emphasis
on the olefin metathesis and gold-mediated reactions; (2) free radical-based organic synthesis; (3) synthetic transformations
performed in a “one-pot” manner involving either tandem reactions or multicomponent reactions; (4) asymmetric reactions catalyzed
by metal and organo-catalysts. The major advances in total synthesis of some complex natural products with significant biological
activities are presented in the second part, with detailed illustrations of ten selected molecules, including dragmacidin
F, abyssomicin C, 11-acetoxy-4-deoxyasbestinin D, pentacycloanammoxic acid, UCS1025A, (−)-merrilactone A, nigellamine A2, (+)-saxitoxin, and Tamiflu (an artificially designed natural product-like molecule). An array of complicated structures
of the natural products synthesized over the last two years is also listed to serve as a convenient lead to the original literature
for the prospective interested readers.
Translated from Progress in Chemistry, 2007, 19(1): 6–34 [译自: 化学 进展] 相似文献
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Córdova A Ibrahem I Casas J Sundén H Engqvist M Reyes E 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(16):4772-4784
Hexose sugars play a fundamental role in vital biochemical processes and their biosynthesis is achieved through enzyme-catalyzed pathways. Herein we disclose the ability of amino acids to catalyze the asymmetric neogenesis of carbohydrates by sequential cross-aldol reactions. The amino acids mediate the asymmetric de novo synthesis of natural L- and D-hexoses and their analogues with excellent stereoselectivity in organic solvents. In some cases, the four new stereocenters are assembled with almost absolute stereocontrol. The unique feature of these results is that, when an amino acid is employed as the catalyst, a single reaction sequence can convert a protected glycol aldehyde into a hexose in one step. For example, proline and its derivatives catalyze the asymmetric neogenesis of allose with >99 % ee in one chemical manipulation. Furthermore, all amino acids tested catalyzed the asymmetric formation of natural sugars under prebiotic conditions, with alanine being the smallest catalyst. The inherent simplicity of this catalytic process suggests that a catalytic prebiotic "gluconeogenesis" may occur, in which amino acids transfer their stereochemical information to sugars. In addition, the amino acid catalyzed stereoselective sequential cross-aldol reactions were performed as a two-step procedure with different aldehydes as acceptors and nucleophiles. The employment of two different amino acids as catalysts for the iterative direct aldol reactions enabled the asymmetric synthesis of deoxysugars with >99 % ee. In addition, the direct amino acid catalyzed C(2)+C(2)+C(2) methodology is a new entry for the short, highly enantioselective de novo synthesis of carbohydrate derivatives, isotope-labeled sugars, and polyketide natural products. The one-pot asymmetric de novo syntheses of deoxy and polyketide carbohydrates involved a novel dynamic kinetic asymmetric transformation (DYKAT) mediated by an amino acid. 相似文献
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氮杂Wittig反应的最近进展 总被引:22,自引:2,他引:20
综述了最近几年氮杂Wittig反应的研究进展,包括分子间氮杂Wittig反应、分子内氮杂wittig反应及串联的氮杂Wittig反应。讨论了氮杂Wittig反应在一些含氮杂环、稠杂环及天然产物合成中的应用。 相似文献
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2(5H)-呋喃酮结构单元广泛存在于天然产物中,同时许多2(5H)-呋喃酮类化合物也是重要的有机合成中间体.因此,基于常见2(5H)-呋喃酮的有机合成研究近年来引起了人们的关注,尤其是金属催化的2(5H)-呋喃酮反应的地位日趋彰显重要,从而成为众多化学工作者的研究热点.按照反应类型的不同,对近年来金属催化的2(5H)-呋喃酮反应的研究进展进行了综述,主要包括Sonogashira,Suzuki,Stille等偶联反应,以及Michael加成反应、Friedel-Crafts烷基化反应、Baylis-Hillman反应、亲核取代反应、还原反应等. 相似文献
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In marked contrast to Michael reactions, oxa-Michael reactions have not been used as standard transformations in organic synthesis until quite recently. This was mainly due to a lack of reactivity and selectivity, although the potential products of such reactions are valuable intermediates. This tutorial review presents recent major advances in the field of oxa-Michael (sometimes called oxo-Michael or oxy-Michael) reactions and applications in the total synthesis of complex natural products. 相似文献
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本文按合成产物的结构类型,综述分子内 Diels-Alder 反应在有机合成方面的新进展。 相似文献
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The hydroamination of olefins is a long-standing goal for transition metal catalysis. And the metal-catalyzed addition of amines to carbon-carbon double bonds is an unsolved, synthetically important problem. Although recent advances have made using lanthanide and precious metal complexes, there are few excellent catalyst that display broad functional group tolerance and useful rates for an intermolecular aza-Michael addition. As such, the development of efficient synthetic methods leading to a-amino carbonyl compounds and derivatives has attracted much attention in organic synthesis. Although recent advances have made this route more attractive, development of cheaper, simpler, and more efficient metal catalyst is highly desirable. We also have been interested in developing a reaction that uses catalytic quantities of minimally toxic, readily available, economic reagent should greatly contribute to the creation of environmental benign processes.The recent interest in aqueous medium metal-mediated carbon-carbon and carbon-heteroatom and formations led to the contributors for such reactions. Furthermore, development of organic reactions in water will contribute to the progress of green and quasi-nature catalysis chemistry. Surprisingly however, there is few report on conjugate additions of amines to a,a-unsaturated carbonyl compounds in water.Herein, we report a new protocol that employs air stable copper salts as efficient catalyst in the aza-Michael reaction under mild reaction conditions. Advantages of the protocol include high-yielding reactions that can be conducted at ambient temperature; the use of readily available and stable copper salts as the catalyst, and the reaction was successfully performed in environmental benign solvent, water.Finally, we have utilized a variety of aliphatic amines successfully with different á,(a)-unsaturated compounds catalyzed by simple hydrophilic ionic liquid, bmimBF4 in water. Interestingly, all the aliphatic amines gave almost quantitative in yield with á,(a)-ethylenic compounds. The present reactions with its mild reaction conditions open a novel entry to synthesis of a-amino carbonyl compounds by simple procedure. 相似文献