共查询到19条相似文献,搜索用时 125 毫秒
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中国番荔枝科植物抗癌有效成分研究 总被引:6,自引:0,他引:6
介绍了近年来我们实验室中国番荔枝科植物抗癌有效成分研究工作。从番荔枝科5种紫玉盘属植物,5种哥纳香属植物,1种番荔枝属植物,1种囊瓣木属植物中分离得到59种新的番荔枝内酯,32种新的多氧取代环己烯,12种新的苯乙烯吡喃酮和3种新的生物碱,并通过化学和光谱方法鉴定了它们的结构。大部分化合物显示了较强的抗癌活性。并对抗癌活性成分海南哥纳香醇甲进行了全合成。 相似文献
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景洪哥纳香和大叶紫玉盘化学成分研究 总被引:2,自引:0,他引:2
从景洪哥纳香和大叶紫玉盘根醇提物中,采用色谱分离方法,分别得到43个和 33个化合物,通过波谱技术和化学方法鉴定了这些化合物的结构。其中,从景洪哥 纳香根中得到1个新化合物,命名为8-乙酰基-9-去氧哥纳香吡喃吡喃酮(1); 从大叶紫玉盘根中得到1个新化合物,命名为大叶素A(2)。另外,从景洪哥纳香 根中,还分离得到一个神经鞘胺醇苷成分混合物asteriacerebrosides (3),并通 过GC-MS技术,鉴定了该混合物的脂肪酸部分(FAM)和长链胺部分(LCB)的种类 数目及碳链长度。结果表明,3中脂肪酸部分,含7个脂肪酸,碳链长度分别是16, 18, 19, 20, 21, 22和23个碳;其长链胺部分包含5个脂肪胺,对应链长度为21, 22,23,24和25个碳。 相似文献
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利用柱层析法(硅胶,C18)从日香桂根的乙酸乙酯提取物中分离出8个单体化合物[女贞苷(1),连翘苷(2),(+)-羟基松脂醇-1-O-β-D-葡萄糖(3),(+) 环橄榄树脂素(4), 2α,3β-二羟基乌苏-12-烯-28酸(5),对羟基苯乙醇(6),(-) 橄榄脂素(7)和橄榄树脂素-4-O-β-D-葡萄糖苷(8)],其结构经1H NMR和13C NMR确证。5为首次在木犀科植物中发现,4为首次在木犀属植物中发现,2, 3, 7和8为首次在日香桂植物中发现。 相似文献
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提出了基质固相分散一高效液相色谱法测定五味子中的尼哥纳乐酸的方法.将样品与硅胶以质量比1比4混合研磨后装入固相萃取柱,用纯的二氯甲烷以5 mL·min-1的流量淋洗,以除去共存干扰物.用二氯甲烷-丙酮(9+1)混合液将尼哥纳乐酸从固相萃取柱上洗脱,吹氮浓缩后,以ZORBAX Stable Bound C<,18>(4.6 mm× 100 mm,1.8μm)快速分离柱为固定相,甲醇-水(82+18)为流动相,用蒸发光散射检测器检测.峰面积与尼哥纳乐酸的质量浓度在2.0~400.0 mg·L-1范围内呈线性关系,检出限(3S/N)为20μg·L-1.用此法分析五味子样品,所得结果的相对标准偏差(n=7)小于2.0%,标准加入回收率在96.8%~101.5%之间. 相似文献
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乌骨藤中五环三萜类化合物的分离鉴定 总被引:2,自引:0,他引:2
利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法及半制备高效液相色谱法,从乌骨藤的正丁醇萃取物中分离得到4种五环三萜类化合物。利用核磁共振谱、质谱、红外光谱等分析方法对化合物结构进行了分析和表征,确定了4种化合物分别为β-香树脂醇(β-amyrin)、白桦酯醇(betulin)、白桦酯酸(betulinic acid)和羽扇豆醇(lupeol),它们为首次在牛奶菜属植物中发现,其中后3种化合物具有抗肿瘤活性。 相似文献
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九里香[Murraya paniculata(L.)Jack.]属芸香科(Rutaceae)植物,民间主要用于活血散瘀、消炎止痛.广东省阳山县和云南西双版纳产的九里香中所含的化学成分我们已有报道.在我们研究此植物的抗凝血活性成分的过程中,从海南九里香叶和细枝中得到四种香豆精化合物(1a~d)和一种黄酮化合物,其中海南九里香内酯(1a)(hainanmurpanin)为新化合物.本文报道它们的分离和结构鉴定. 化合物1a,C_(17)H_(18)O_6的紫外光谱显示7-甲氧基-8-烷基香豆精的特征吸收;红外光谱显示三个羰基和芳环的吸收;根据核磁共振谱提供的共振信号,可以推测1a的化学结构为 相似文献
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A new aristololactam, 5-methoxyaristololactam I (1), was isolated from an ethanol extract of the whole plant of Asarum ichangense C. Y. Cheng et C. S. Yang, together with twenty known compounds (2-21). The structure of 1 was elucidated by spectroscopic methods. Compounds 11, 13, 17, and 19 were isolated from Aristolochiaceae for the first time. Compounds 2, 14, and 15 are considered as common constituents of the genus Asarum. 相似文献
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On-line (HPLC-NMR) and off-line (HPLC, NMR and MS) methodologies were used to profile the constituents present in the crude extract of Lasiopetalum macrophyllum. On-flow and stop-flow HPLC-NMR supported the presence of trans-tiliroside and permitted partial identification of cis-tiliroside and 4'-methoxy-trans-tiliroside. Off-line isolation led to the unequivocal identification of four flavanoid glycosides including a new structural derivative, 4'-methoxycis-tiliroside. This is the first report of flavonoid glycosides occurring in this plant genus. In addition, a number of structure revisions have been proposed for previously reported flavonoid glycosides that were incorrectly assigned. 相似文献
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Chaudhary S Thomas V Todaro L Legendre O Pecic S Harding WW 《Natural product communications》2008,3(11):1747-1750
From an acetone extract of the aerial parts of Tidestromia oblongifolia (Amaranthaceae), a new drimane sesquiterpenoid bearing an 11,12,13-trihydroxydrimene skeleton (1) as well as the 11,12 acetonide of 1 were isolated. Three known stigmastane triterpenoids were also isolated. Structures were elucidated with the aid of 1D and 2D NMR spectroscopic techniques. The absolute configuration of 1 was confirmed by single-crystal x-ray crystallography. This is the first report on phytochemical constituents from any plant of the genus Tidestromia and is the first report of the occurrence of drimanes in the Amaranthaceae. 相似文献
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On-line (HPLC-NMR) and off-line (HPLC, NMR and MS) methodologies were used to profile the constituents present in the crude extract of Lasiopetalum macrophyllum. On-flow and stop-flow HPLC-NMR supported the presence of trans-tiliroside and permitted partial identification of cis-tiliroside and 4'-methoxy-trans-tiliroside. Off-line isolation led to the unequivocal identification of four flavanoid glycosides including a new structural derivative, 4'-methoxy-cis-tiliroside. This is the first report of flavonoid glycosides occurring in this plant genus. In addition, a number of structure revisions have been proposed for previously reported flavonoid glycosides that were incorrectly assigned. 相似文献
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SiWANG ShengJunDAI RuoYunCHEN ShiShanYU DeQuanYU 《中国化学快报》2003,14(5):487-488
Two new styryllactones,iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone,were isolated from the roots of Goniothalamus cheliensis.Their structure were elucidated on the basis of spectroscopic and chemical evidences. 相似文献
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《中国化学快报》1998,(11)
GoniothalamusgrghthiiHook.F.etThoms(Annonaceae)isatropicalplantdistributedinsouthChina,IndiaandThailand.InwiderangescreeningfOrantitumoragentsfromAnnonaceaeplants,thecthanolicextractofrhizomesofG.grghthiiwasfOundtohc-..activeagainstvarioushumancancercelllines.Furtherpuriflcationoftheextractyieldedthreenewalkaloids,griffithdionel,griffiazanoneA2andgriffiazanoneB3wh()scstructuresweree1ucidatedbyvariousNMRtechniques,includingHMBC,NOEexperiments.(R)-and(S)-MTPAderivativeswerepreparedtod… 相似文献
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Qing MU * Rong Wei TENG Chao Ming LI De Zu WANG Yu WU Han Dong SUN Chang Qi HU Phytochemistry Laboratory Kunming Institute of Botany Chinese Acadmy of Sciences Kunming School of Pharmacy Fudan University Shanghai 《中国化学快报》2001,(7)
Ongoing phytochemical studies on Goniothalamus species have led to the isolation of a number of annonaceous acetogenins and unusual new styryllactones which were found to possess significant cytotoxic activities against several hunan tumour cell lines1,2. Firstly, cyclopeptides were reported to be isolated from genus Goniothalamus in this paper.Goniothalamus leiocarpus is an evergreen tree which grows in the south of Yunnan, China. Four new anticancer styryllactones3,4 from the stem bark and… 相似文献
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Miao Miao Jiang Xue Zhang Yi Dai Hao Gao Hong Wei Liu Nai Li Wang Wen Cai Ye Xin Sheng Yao 《中国化学快报》2008,19(3):302-304
(3S)-2-Oxo-5,12-dimethoxy-3-hydroxy-3-methylbenz[f]indoline (1), a new benzoxindole alkaloid, along with two known alkaloids, was isolated from the root barks of Goniothalamus cheliensis Hu. The structure was elucidated by spectroscopic evidences, and the absolute configuration was determined by CD spectrum. 相似文献