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抗癌药物与DNA作用的电化学研究进展 总被引:13,自引:0,他引:13
针对当前电化学研究领域中的热门课题——DNA的电化学研究,阐述了与DNA的电化学研究相关的理论基础,其中包括作用机理和作用模式等,概述了其近几年的研究进展,并在此基础上对抗癌药物与DNA的相互作用的电化学研究工作特别是该研究的潜在应用,即抗癌药物的新型筛选方法——电化学筛选方法进行了介绍。 相似文献
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电化学免疫分析法研究进展 总被引:27,自引:8,他引:27
电化学免疫分析法是将免疫分析与电化学分析技术相结合的一种免疫分析新方法,近十多年来,电化免疫分析的研究有了迅速的发展。本文对电化学的免疫分析法的标记物、免疫方法、电化学检测技术进行了概括总结,并展望了电化学免疫分析的发展前景。 相似文献
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非线性光学方法在电化学研究中的应用杨勇,林祖赓(固体表面物理化学国家重点实验室,厦门大学化学系361005)近年来,由于大功率脉冲型激光器的发展,非线性光学方法在表面科学及电化学中的应用逐步得到重视并有了较快的发展。不少的实验事实已经表明,由于其独特... 相似文献
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对扫描电化学显微镜(Scanning Electrochemical Microscope,SECM)的发展及其在界面电化学中的研究应用进行了评述。介绍了SECM的工作原理以及常用的操作模式,并对SECM在液/液界面、固/液界面等方面的应用进行了总结。 相似文献
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不断创新的电化学研究方法:厦门大学电化学研究工作简介之二 总被引:2,自引:0,他引:2
不断创新的电化学研究方法(厦门大学电化学研究工作简介之二)林仲华,罗瑾,田中群,孙世刚,林昌健,毛秉伟,杨勇,林华水执笔(固体表面物理化学国家重点实验室,厦门大学化学系,厦门361005)1历史的回顾与自然科学的其它分支学科一样,电化学科学的建立和纵... 相似文献
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乙酰胆碱酯酶(AChE)是普遍存在于周围神经系统中的一种关键酶,可特异性催化底物乙酰胆碱发生水解反应,产生胆碱和醋酸盐,这一过程与阿尔兹海默症和炎症过程等相关疾病有着密切的关系.在本研究中通过硫代胆碱(TCh)与Cu(Ⅱ)反应合成了一种铜-巯基配位聚合物[命名为TCh-Cu(Ⅱ)CP],并发现该聚合物具有独特的电催化活性,基于此构建了一种用于AChE活性检测和抑制剂筛选的新型电化学生物传感平台.结果表明,该聚合物修饰在电极表面后可以催化邻苯二胺产生明显的电化学信号,信号强度与AChE浓度在0.05至100 mU·mL-1范围内具有良好的线性关系,检出限为0.03 mU·mL-1(S/N=3),通过该方法还实现了AChE抑制剂的筛选.和传统的检测方法相比,该传感方法具有制备简单、选择性高和灵敏度高等特点. 相似文献
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López-Vallejo F Caulfield T Martínez-Mayorga K Giulianotti MA Nefzi A Houghten RA Medina-Franco JL 《Combinatorial chemistry & high throughput screening》2011,14(6):475-487
Virtual screening is increasingly being used in drug discovery programs with a growing number of successful applications. Experimental methodologies developed to speed up the drug discovery processes include high-throughput screening and combinatorial chemistry. The complementarities between computational and experimental screenings have been recognized and reviewed in the literature. Computational methods have also been used in the combinatorial chemistry field, in particular in library design. However, the integration of computational and combinatorial chemistry screenings has been attempted only recently. Combinatorial libraries (experimental or virtual) represent a notable source of chemically related compounds. Advances in combinatorial chemistry and deconvolution strategies, have enabled the rapid exploration of novel and dense regions in the chemical space. The present review is focused on the integration of virtual and experimental screening of combinatorial libraries. Applications of virtual screening to discover novel anticancer agents and our ongoing efforts towards the integration of virtual screening and combinatorial chemistry are also discussed. 相似文献
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An integrated multireactor system for 2 x 2 parallel organic synthesis has been developed on a single glass microchip. Three-dimensional channel circuits in the chip were fabricated by laminating three glass plate layers. The fabrication method is a straightforward extension of the conventional one, and topological equivalence for any three-dimensional circuits can be constructed easily with it. 2 x 2 phase-transfer amide formation reactions, which constitute a simple model for combinatorial synthesis, were successfully carried out on the microchip, and the integrity of the three-dimensional circuits was confirmed. Combinatorial chemistry with multi-microreactors, in conjunction with a high-throughput screening method based on micro-TAS technologies, is expected to provide an efficient tool for drug discovery. 相似文献
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Pd微电极阵列表面纳米薄膜的方波电位制备及其特殊的红外性能 总被引:1,自引:0,他引:1
制备了单根可寻址Pd微电极阵列,运用方波电位法对阵列上每根Pd微电极处理不同时间,诱导生成一系列不同纳米结构的Pd薄膜.以CO为探针分子,结合原位显微傅里叶变换红外反射光谱进行表面组合电化学研究,一次性地获得CO吸附在不同纳米结构Pd薄膜上的红外光谱.观察到随方波电位法处理时间的逐步增加,桥式吸附态CO的红外光谱峰从正常吸收光谱到类Fano光谱,再到异常红外光谱的转变过程.结合扫描电子显微镜观察纳米薄膜的形貌,发现不同红外光谱特征都对应着特定的纳米结构. 相似文献
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Combinatorial synthesis and screening were used to identify methanol-tolerant non-platinum cathode electrocatalysts for use in direct methanol fuel cells (DMFCs). Oxygen reduction consumes protons at the surface of DMFC cathode catalysts. In combinatorial screening, this pH change allows one to differentiate active catalysts using fluorescent acid-base indicators. Combinatorial libraries of carbon-supported catalyst compositions containing Ru, Mo, W, Sn, and Se were screened. Ternary and quaternary compositions containing Ru, Sn, Mo, Se were more active than the "standard" Alonso-Vante catalyst, Ru(3)Mo(0.08)Se(2), when tested in liquid-feed DMFCs. Physical characterization of the most active catalysts by powder X-ray diffraction, gas adsorption, and X-ray photoelectron spectroscopy revealed that the predominant crystalline phase was hexagonal close-packed (hcp) ruthenium, and showed a surface mostly covered with oxide. The best new catalyst, Ru(7.0)Sn(1.0)Se(1.0), was significantly more active than Ru(3)Se(2)Mo(0.08), even though the latter contained smaller particles. 相似文献
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Stafslien SJ Bahr JA Feser JM Weisz JC Chisholm BJ Ready TE Boudjouk P 《Journal of combinatorial chemistry》2006,8(2):156-162
Combinatorial, high-throughput capabilities have been established to aid in the rapid development of new and effective antifouling marine coatings for naval applications. A biological screening process involving marine bacteria was developed that allows for rapid and effective quantification of bacterial biofilm growth and retention on large numbers of coating surfaces in parallel. The screening process involves (1) multiwell plate modifications for coating deposition, (2) deposition of combinatorial coating libraries via an automated liquid dispensing robot, (3) coating thickness measurements of cured coatings, (4) preconditioning of coatings via immersion in deionized water, (5) bacterial incubation, (6) plate processing, and (7) data analysis for identification of promising candidates. The details of the method developed are described in this document. 相似文献
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Jun WANG Kai Ying LIU Li WANG Ji Ling BAI 《中国化学快报》2006,17(1):49-52
The techniques of combinatorial chemistry have recently been applied to the discovery of new asymmetric catalyst for a variety of organic transformations1-3. Using combina- torial methods, it is straightforward to generate thousands of potential asymmetri… 相似文献