Global stability and periodic solution of the viral dynamics

It is well known that the mathematical models provide very important information for the research of human immunodeficiency virus-type 1 and hepatitis C virus (HCV). However, the infection rate of almost all mathematical models is linear. The linearity shows the simple interaction between the T cells and the viral particles. In this paper, we consider the classical mathematical model with saturation response of the infection rate. By stability analysis we obtain sufficient conditions on the parameters for the global stability of the infected steady state and the infection-free steady state. We also obtain the conditions for the existence of an orbitally asymptotically stable periodic solution. Numerical simulations are presented to illustrate the results.     

On the stability of hematopoietic model with feedback control

We propose and analyze a mathematical model of the production and regulation of blood cell population in the bone marrow (hematopoiesis). This model includes the primitive hematopoietic stem cells (PHSC), the three lineages of their progenitors and the corresponding mature blood cells (red blood cells, white cells and platelets). The resulting mathematical model is a nonlinear system of differential equations with several delays corresponding to the cell cycle durations for each type of cells. We investigate the local asymptotic stability of the trivial steady state by analyzing the roots of the characteristic equation. We also prove by a Lyapunov function the global asymptotic stability of this steady state. This situation illustrates the extinction of the cell population in some pathological cases.     

Mathematical model of hematopoiesis dynamics with growth factor-dependent apoptosis and proliferation regulations

We consider a nonlinear mathematical model of hematopoietic stem cell dynamics, in which proliferation and apoptosis are controlled by growth factor concentrations. Cell proliferation is positively regulated, while apoptosis is negatively regulated. The resulting age-structured model is reduced to a system of three differential equations, with three independent delays, and existence of steady states is investigated. The stability of the trivial steady state, describing cells dying out with a saturation of growth factor concentrations is proven to be asymptotically stable when it is the only equilibrium. The stability analysis of the unique positive steady state allows the determination of a stability area, and shows that instability may occur through a Hopf bifurcation, mainly as a destabilization of the proliferative capacity control, when cell cycle durations are very short. Numerical simulations are carried out and result in a stability diagram that stresses the lead role of the introduction rate compared to the apoptosis rate in the system stability.     

Equilibrium switching and mathematical properties of nonlinear interaction networks with concurrent antagonism and self-stimulation

Concurrent decision-making model (CDM) of interaction networks with more than two antagonistic components represents various biological systems, such as gene interaction, species competition and mental cognition. The CDM model assumes sigmoid kinetics where every component stimulates itself but concurrently represses the others. Here we prove generic mathematical properties (e.g., location and stability of steady states) of n-dimensional CDM with either symmetric or asymmetric reciprocal antagonism between components. Significant modifications in parameter values serve as biological regulators for inducing steady state switching by driving a temporal state to escape an undesirable equilibrium. Increasing the maximal growth rate and decreasing the decay rate can expand the basin of attraction of a steady state that contains the desired dominant component. Perpetually adding an external stimulus could shut down multi-stability of the system which increases the robustness of the system against stochastic noise. We further show that asymmetric interaction forming a repressilator-type network generates oscillatory behavior.     

Effect of time delay in an autotroph-herbivore system with nutrient cycling

In the present study we consider a mathematical model of a non-interactive type autotroph-herbivore system in which the amount of autotroph biomass consumed by the herbivore is assumed to follow a Holling type II functional response. We have also incorporated discrete time delays in the numerical response term to represent a delay due to gestation, and in the recycling term which represents the time required for bacterial decomposition. We have derived conditions for global asymptotic stability of the model in the absence of delays. Conditions for delay-induced asymptotic stability of the steady state are also derived. The length of the delay preserving stability has been estimated and interpreted ecologically.     

Stability Analysis of a Diffusive Predator-prey Model with Hunting Cooperation

In this paper, we are concerned with the dynamics of a diffusive predator-prey model that incorporates the functional response concerning hunting cooperation. First, we investigate the stability of the semi-trivial steady state. Then, we investigate the influence of the diffusive rates on the stability of the positive constant steady state. It is shown that there exists diffusion-driven Turing instability when the diffusive rate of the predator is smaller than the critical value, which is dependent on the diffusive rate of the prey, and the semi-trivial steady state and the positive constant steady state are both locally asymptotically stable when the diffusive rate of the predator is larger than the critical value. Finally, the nonexistence of nonconstant steady states is discussed.     

Global stability of solutions to a free boundary problem of ductal carcinoma in situ

In the paper we present some remarks on the global stability of steady state solutions to a free boundary model studied by Xu (2004) and also prove some new results of global stability of steady state solutions to the model.     

Dynamics of a spatiotemporal model on populations in a polluted river

In this paper, we investigate the dynamics for a reaction–diffusion–advection system which models populations in a polluted river. More precisely, we study the stability of steady states, which yields sufficient conditions that lead to population persistence or extinction. Furthermore, some dependence of the stability of the toxicant-only steady state and the population-toxicant coexistence steady state on the model parameters are given.     

软件再生系统解的渐近稳定性分析

用补充变量的方法建立了各状态之间转移概率服从一般分布的软件再生系统的数学模型 .并用泛函分析中的 C0 半群理论对系统算子的谱点分布情况作了研究 ,证明了系统算子的谱点均位于复平面左半平面且在虚轴上除 0点外均为系统算子的正则点 ,作为线性算子半群稳定性的一个直接结果 ,得出了软件再生系统解的渐近稳定性     

Role of migratory bird population in a simple eco-epidemiological model

Migratory birds play a vital role in the spread of diseases such as West Nile Virus, Salmonella, etc. In this paper we propose and analyse (both analytically and numerically) a single-season mathematical model to observe the dynamical changes that take place due to the introduction of a disease by migratory birds. We observe that the force of infection and the predation rate play important roles in maintaining stability around the positive steady state. We also observe that proper predation may even result in the extinction of the infective migratory prey population from the system.     

Nonlinear dynamics of open marine population with space-limited recruitment: The case of mortality control

In this paper we develop a nonlinear extension for the open marine population model which has been proposed by Roughgarden et al. [Ecology 66 (1985) 54-67]. To avoid the negative population density, which is a drawback of the original model, we introduce a nonlinear mechanism that the mortality rate depends on the size of area occupied by the adult population. Then we give a rigorous mathematical framework to analyse the model equation, and we show sufficient conditions for stability and instability of the steady state. Our instability result suggests, as was proposed by Roughgarden et al., that there exists a sustained oscillation of the population density.     

Asymptotic behavior and stability switch for a mature–immature model of cell differentiation

We consider a nonlinear age-structured model, inspired by hematopoiesis modelling, describing the dynamics of a cell population divided into mature and immature cells. Immature cells, that can be either proliferating or non-proliferating, differentiate in mature cells, that in turn control the immature cell population through a negative feedback. We reduce the system to two delay differential equations, and we investigate the asymptotic stability of the trivial and the positive steady states. By constructing a Lyapunov function, the trivial steady state is proven to be globally asymptotically stable when it is the only equilibrium of the system. The asymptotic stability of the positive steady state is related to a delay-dependent characteristic equation. Existence of a Hopf bifurcation and stability switch for the positive steady state is established. Numerical simulations illustrate the stability results.     

Nonlinear dynamics of endothelial cells

We propose a mathematical model that governs endothelial cell pattern formation on a biogel surface. The model accounts for diffusion and chemotactic motion of the cells, diffusion of the growth factor and effective biochemical reactions. The model admits a basic steady state that corresponds to a spatially uniform distribution of both the cells and the growth factor. We perform a weakly nonlinear stability analysis of the basic state in order to determine whether spatially nonuniform steady patterns can appear in the system when the basic state becomes unstable. The main results can be summarized as follows. No steady patterns can bifurcate from the basic state if the rate of decay of the growth factor is small. Increasing the rate of decay of the growth factor allows one to observe steady patterns, provided that diffusion of the growth factor is sufficiently slow. Specifically, the work focuses on the occurrence of hexagons and stripes. Most often hexagons are observed. In order for stripes to occur, the chemotactic sensitivity of the endothelial cells and/or their biochemical activity have to be reduced.     

Temporal and spatiotemporal variations in a mathematical model of macrophage–tumor interaction

In the present paper we study a three-component mathematical model of tumor–immune system interaction. A number of solid tumors contain a high proportion of macrophages and these immune cells are known to have a remarkable impact on the progression and dormancy of such tumors. We assume these macrophages as the main immune system component facilitating tumor destruction. Stability criteria of the basic model around the steady state of coexistence are derived. Next, we consider the process of macrophage activation as non-instantaneous by using a distributed delay with a weak kernel and obtain a range for the macrophage death rate that ensures system stability. Finally, we incorporate the spatial irregularity of solid tumors by making the delay nonlocal. Analysis of the resulting spatiotemporal model gives a number of thresholds in terms of different system parameters that guarantee tumor stability. Numerical simulations are performed to justify analytical findings.     

The role of four regulatory hormones in controlling testicular function in a delay model

Our proposed mathematical model for the secretion in hypothalamus-pituitary-gonadal axis introduces four regulatory hormones viz. GnRH, FSH, Testosterone, and Inhibin. Here, we have considered four dimensional delay differential equations with multiple negative feedback loops which accounts for the pulsatile release of these hormones. We have derived the conditions for local asymptotic stability of the steady state and have estimated the length of delay to preserve the stability. Regions for stability and oscillations of the system are given in K − τ and m − τ plane, and the role of Inhibin in regulating the male fertility status by altering the FSH level has been clearly shown by computer simulation of the model.     

Travelling waves in an infectious disease model with a fixed latent period and a spatio–temporal delay

This paper is concerned with the existence of travelling waves to an infectious disease model with a fixed latent period and a spatio–temporal delay. By analyzing the corresponding characteristic equations, the local stability of a disease-free steady state and an endemic steady state to this model is discussed. By constructing a pair of upper–lower solutions, we use the cross iteration method and the Schauder’s fixed point theorem to prove the existence of a travelling wave solution connecting the disease-free steady state and the endemic steady state. Numerical simulations are carried out to illustrate the main results.     

The existence and stability of steady states for a prey-predator system with cross diffusion of quasilinear fractional type

This paper is concerned with the existence and stability of steady states for a prey-predator system with cross diffusion of quasilineax fractional type. We obtain a sufficient condition for the existence of positive steady state solutions by applying bifurcation theory and a detailed priori estimate. In virtue of the principle of exchange of stability, we prove the stability of local bifurcating solutions near the bifurcation point.     

The Existence and Stability of Steady States for a Prey-predator System with Cross Difusion of Quasilinear Fractional Type

This paper is concerned with the existence and stability of steady states for a prey-predator system with cross difusion of quasilinear fractional type.We obtain a sufcient condition for the existence of positive steady state solutions by applying bifurcation theory and a detailed priori estimate.In virtue of the principle of exchange of stability,we prove the stability of local bifurcating solutions near the bifurcation point.     

Nonlinear Eigenvalue Problems in the Stability Analysis of Morphogen Gradients

This paper is concerned with several eigenvalue problems in the linear stability analysis of steady state morphogen gradients for several models of Drosophila wing imaginal discs including one not previously considered. These problems share several common difficulties including the following: (a) The steady state solution which appears in the coefficients of the relevant differential equations of the stability analysis is only known qualitatively and numerically. (b) Though the governing differential equations are linear, the eigenvalue parameter appears nonlinearly after reduction to a problem for one unknown. (c) The eigenvalues are determined not only as solutions of a homogeneous boundary value problem with homogeneous Dirichlet boundary conditions, but also by an alternative auxiliary condition to one of the Dirichlet conditions allowed by a boundary condition of the original problem. Regarding the stability of the steady state morphogen gradients, we prove that the eigenvalues must all be positive and hence the steady state morphogen gradients are asymptotically stable. The other principal finding is a novel result pertaining to the smallest (positive) eigenvalue that determines the slowest decay rate of transients and the time needed to reach steady state. Here we prove that the smallest eigenvalue does not come from the nonlinear Dirichlet eigenvalue problem but from the complementary auxiliary condition requiring only to find the smallest zero of a rational function. Keeping in mind that even the steady state solution needed for the stability analysis is only known numerically, not having to solve the nonlinear Dirichlet eigenvalue problem is both an attractive theoretical outcome and a significant computational simplification.     

Travelling waves of a delayed SIRS epidemic model with spatial diffusion

This paper is concerned with the existence of travelling waves to an SIRS epidemic model with bilinear incidence rate, spatial diffusion and time delay. By analysing the corresponding characteristic equations, the local stability of a disease-free steady state and an endemic steady state to this system under homogeneous Neumann boundary conditions is discussed. By using the cross iteration method and the Schauder’s fixed point theorem, we reduce the existence of travelling waves to the existence of a pair of upper-lower solutions. By constructing a pair of upper-lower solutions, we derive the existence of a travelling wave solution connecting the disease-free steady state and the endemic steady state. Numerical simulations are carried out to illustrate the main results.