热分析技术在药物研究中的应用

本文综述了热分析法在药物研究中的应用及发展趋势。由于热分析技术的发展和热分析仪的不断改进及自动化程度的提高,热分析法在药品检验、新药开发、剂型研究以及药物的热分解动力学研究等方面发挥越来越大的作用。     

热分析技术及其在高分子材料研究中的应用

简要介绍了热分析技术——热重法、差热分析、差示扫描量热法、热机械分析法和动态机械热分析法等及其在高分子材料领域的广泛应用。热分析技术的方法具有快速、方便等优点,在高分子材料的研究中发挥着重要作用。     

中国化学会第四届全国热分析动力学与热动力学学术会议(第一轮通知)

受中国化学会委托,由中国化学会化学热力学和热分析专业委员会主办,河北师范大学承办的第四届全国热分析动力学与热动力学学术会议将于2013年5月17-19日在石家庄召开。本次会议将就近年来热分析动力学和热动力学以及热分析与量热在理论研究、新仪器设计与分析技术方面的进展以及在无机、有机、高分子、新材料、生物医药等各个领域中的应用进行学术研讨和交流。会议将邀请国内从事热分析动力学和热动力学及热化学领域的著名专家、中青年学者和仪器生产厂商参加学术交流和技术探讨。会议期间还将展示一批国内外最新热分析仪器及相关产品,提供大量的最新技术、最新测试方法等资料。欢迎广大科技工作者踊跃投稿,积极参加。欢迎相关企业     

杉木热解及燃烧特性热天平模拟试验研究

对南方森林主要树种－杉木的变工况热解行为进行了热重分析（TG）和差热分析(DTG)研究。将试样分别加热到200 ℃、300 ℃、400 ℃和500 ℃做空气变氮气、氮气变空气热天平试验,模拟实际火场由于火势发展产生的局部缺氧状态及由缺氧状态转变为富氧的状态;在空气气氛下将试样分别加热到250 ℃、300 ℃、350 ℃、400 ℃和450 ℃,然后冷却到50 ℃再继续加热直到700 ℃,模拟火场中可燃物不完全燃烧后的回燃情况。通过试验结果分析,深入研究了环境气氛变化对试样热解的影响。给出了杉木热解的两阶段一级反应模型,通过模型计算得出在233.3 ℃～369.9 ℃、369.9 ℃～490.8 ℃热解二阶段的活化能分别为77.85 kJ·mol－1、138.18 kJ·mo－1,频率因子分别为1.95×106、 4.84×109。     

计算药物分析(计算分析化学)程序包

计算药物分析（计算分析化学）程序包安登魁，相秉仁，张尊建，郭寅龙（中国药科大学分析计算中心南京２１０００９）计算药物分析是计算机技术、应用数学和药物分析相互结合、相互渗透而孕育出的一门新的药学边缘学科，是研究将计算机技术应用于药学学科的方法学。虽然其...     

热重分析技术及其在高分子表征中的应用

热重分析技术(TGA)是在程序控制温度和设定气氛下表征材料受热过程中的质量随温度或时间变化的高精度研究工具,具有重复性好、灵敏度高和热过程控制精准等优点.近年来,TGA技术在高分子材料领域得到了广泛应用,促进了高分子材料热稳定性、组成分析以及热分解机理等材料细观热响应特性的深入研究.本文分别从热重分析基本原理、仪器校准...     

中国化学会第四届全国热分析动力学与热动力学学术会议(第一轮通知)

受中国化学会委托,由中国化学会化学热力学和热分析专业委员会主办,河北师范大学承办的第四届全国热分析动力学与热动力学学术会议将于2013年5月17-19日在石家庄召开。本次会议将就近年来热分析动力学和热动力学以及热分析与量热在理论研究、新仪器设计与分析技术方面的进展以及在无机、有机、高分子、新材料、生物医药等各个领域中的应用进行学术研讨和交流。会议将邀请国内从事热分析动力学和热动力学及热化学领域的著名专家、中青年学者和仪器生产厂商参加学术交流和技术探讨。会议期间还将展示一批国内外最新热     

固相萃取

近１０多年来,固相萃取作为试样预处理技术得到迅速的发展。评述了该技术的特点、装置、方法的建立,应用和前景。文中强调固相萃取在环境分析、药物分析等方面有广泛的应用前景,并总结了近年来固相萃取在药物分析中的应用。     

同步热分析技术在煤炭品质评价和分类鉴别的应用研究

采用经典法(GB/T 212-2008)、常量热重法(Marco-TG)和同步热分析三种方法分析了多种产地的煤炭产品,结果表明,在煤炭样品制备良好的条件下,常量热分析法与经典法的煤炭工业分析值基本吻合,同步热分析(STA)法的结果波动相对较大,可作为半定量的快速评价煤炭品质检测方法;根据褐煤、烟煤和无烟煤燃烧时的差示扫描量热曲线热力学特征,初步探讨了三种煤炭的分类鉴别技术,促进煤炭产品的进出口贸易。     

差示扫描量热法中相变潜热公式的推导

通过考虑热分析过程中存在于试样内的温度梯度,就相变前后试样的比热容发生变化、并且是温度的函数这一普遍情况,推导得到了普遍的用差示扫描量热法求相变潜热的公式     

薄膜基荧光传感检测的研究进展

薄膜基荧光传感器是继离子迁移谱之后,业界公认的一种最具发展潜力的微痕量物质探测技术.由于其具有灵敏性、便携性、实时检测、响应速度快、易于制造、不污染待测体系等优点,在食品检测、环境监测、质量控制和生物医学分析等领域引起了广泛的关注和研究.本文主要综述了近年来薄膜基荧光传感在挥发性气体检测、有毒化学品检测、爆炸物检测、溶液相离子检测以及生物监测等领域的研究进展,并提出了薄膜基荧光传感所面临的挑战与未来的发展方向.     

高效液相色谱法测定氨基酸的研究进展

氨基酸是构成生物体的基础物质,氨基酸分析是生命科学研究中最重要的领域之一。高效液相色谱法因分析速度快、操作简便、检测灵敏、适用范围广等优点而广泛应用于食品工业、制药工业、生命科学研究等领域。该文综述了高效液相色谱分析氨基酸的方法,包括柱后衍生法、柱前衍生法、高效阴离子交换色谱-积分脉冲安培检测法和高效液相色谱-蒸发光散射检测法。并对上述方法进行了比较,为日常的氨基酸分析提供了参考。     

Breath figures-mediated microprinting allows for versatile applications in molecular biology

Softlithographic processes are currently applied in different fields ranging from microelectronics to biology. One of the main advantages of these techniques stands in the low cost and in its easy use without the need of expensive apparatus. The available procedure is simple and particularly suitable for biological tests: a biomolecule is printed on a suitable substrate and its presence can be further recognized with a given reactants. The use of polydimethylsiloxane (PDMS) is a key step in this technology because printing from PDMS mould is an easy process. We have recently shown that the hexagonal ordered pattern which is obtained by breath figure method on a polystyrene film, generated by arrangements of micrometric holes on the film surface, can be reproduced by PDMS obtaining a positive mould, formed by regularly arranged micrometric protuberances. This mould can be “inked” with a suitable biomolecule solution which is subsequently printed on the desired substrate. With this method no photolithographic step is necessary; regular spots of a few microns can be easily produced without the need of sophisticated apparatus. We report some examples of printing with different molecules which are then recognized by specific reactants. A further advantage of the method we present in this work is related to the multiple printing of the same labelled molecule with the same mould onto several substrates without significant loss of signal.     

通过一步萃取将组蛋白分为多个亚组分的蛋白质组预分离方法的建立

将基于正丙醇、氯化钠和水的双水相体系用于蛋白质组的预分离研究, 并考察了体系酸度及在不同浓度的盐、正丙醇及蛋白质存在时该双水相体系对蛋白质的分离效果. 将经该双水相体系预分离过的蛋白质组样品在未与成相试剂分离的条件下直接用于凝胶电泳分析. 结果表明, 该双水相体系可通过一步萃取将蛋白质组样品分为3个亚组群. 该蛋白质组预分离方法简单、快速、成本低, 并具有生物相容性、可连续操作性、无需昂贵复杂仪器以及在进行电泳分析前无须(或易于)将目标蛋白与成相试剂分离等优点. 该蛋白质组预分离方法的建立在蛋白质组学和方法学方面均有着极为重要的意义.     

Progress of Sonic-Spray Ionization Mass Spectrometry and Its Applications

Sonic-spray ionization (SSI) is a previously developed soft ionization technique which does not need auxiliary methods such as voltage, heating, laser, or corona discharge. Spray ionization can be achieved under normal temperature and atmospheric pressure by inputting high-speed gas coaxial within the capillary. As an atmospheric pressure ion source, this technique was widely used as the interface of liquid chromatography-mass spectrometry at the beginning of its development. Based on the principles of sonic-spray ionization, a variety of easy ambient sonic-spray ionization derived techniques have been developed, which can be used for the in-situ, rapid and real-time analysis of samples with little or without any sample pretreatment. In this paper, the principless and characteristics of sonic-spray ionization were elaborated, and the progress of its application in life sciences, food safety, forensic chemistry, reaction monitoring, and other related fields were summarized.     

SugarDrawer: A Web-Based Database Search Tool with Editing Glycan Structures

In life science fields, database integration is progressing and contributing to collaboration between different research fields, including the glycosciences. The integration of glycan databases has greatly progressed collaboration worldwide with the development of the international glycan structure repository, GlyTouCan. This trend has increased the need for a tool by which researchers in various fields can easily search glycan structures from integrated databases. We have developed a web-based glycan structure search tool, SugarDrawer, which supports the depiction of glycans including ambiguity, such as glycan fragments which contain underdetermined linkages, and a database search for glycans drawn on the canvas. This tool provides an easy editing feature for various glycan structures in just a few steps using template structures and pop-up windows which allow users to select specific information for each structure element. This tool has a unique feature for selecting possible attachment sites, which is defined in the Symbol Nomenclature for Glycans (SNFG). In addition, this tool can input and output glycans in WURCS and GlycoCT formats, which are the most commonly-used text formats for glycan structures.     

微萃取技术在环境分析中的应用

微萃取技术是近年来出现的绿色样品前处理技术。它具有操作简便、环境友好等优点,并且在环境、医药及食品等领域得到广泛的应用。本文仅就固相微萃取和液相微萃取在环境分析中的应用作一简要综述。     

Criteria in Chromatography and Mass Spectrometry – a Comparison Between Regulations in the Field of Residue and Doping Analysis

Residue analysis and doping control aim at the detection of prohibited substances (often registered drugs) in biological matrices and are hence related fields of analysis. In both fields, the detection of such a prohibited substance has legal and economical implications for the persons involved (farmer, horse-owner, trainer or athlete). Hence, the necessary precautions need to be taken to ensure that the unequivocal presence of a substance has indeed been established. In each of these fields of analysis, chromatography and mass spectrometry are the primary techniques used in the identification process and, not surprisingly, the criteria to which these techniques must comply depend on the regulatory authority. It seems illogical that different sets of criteria exist for fields of analysis that are so closely related. However, because of the complexity encountered in these analyses, the creation of an “ideal” set of criteria encompassing and foreseeing all possible difficulties met by the analyst during his work seems impossible. This paper tries to give an overview of the similarities and differences in each set of regulations, while critically pointing out and illustrating pitfalls and positive aspects of each set of regulations in an attempt to aid the analyst in the decision process when regulations leave room for interpretation. The need for the analyst to critically evaluate the regulations is illustrated in two examples.     

Click chemistry-inspired design,synthesis, and molecular docking studies of biscoumarin derivatives using carbon-based acid catalyst

A green and eco-benign synthesis of biscoumarin derivatives using carbon sulfonic acid, a solid support catalyst has been described. The reaction involved a one-pot two-component reaction of 4-hydroxycoumarin and aldehyde using carbon sulfonic acid involving Knoevenegal-Michael condensation. A series of aromatic (bearing electron withdrawing and releasing group) and heteroaromatic aldehydes has been converted to biscoumarins with excellent isolated yields. The reaction is in compliance with green principles, that is, inexpensive catalyst, easy to prepare, nontoxic, easy handling, reusable up to five recycle runs, easy separation, short reaction time, no need of time consuming column purification, high yielding, and so on. The synthesized catalyst and biscoumarin derivatives were well characterized by spectral analysis. The molecular modeling studies showed that the designed molecular scaffolds (3a-j) showed outstanding interaction with methylenetetrahydrofolate reductase (MTHFR) and cytochrome P450 3A4 (CYP3A4) proteins. It was noticed that 3f (−17.55 kJ/mol) and 3d (−26.23 kJ/mol) showed the highest docking score against CYP3A4 and MTHFR proteins, respectively.     

整体柱的制备方法及其应用

整体柱具有渗透性好、制备简单、无需塞了制作等优点,从而避免了由塞了所引起的问题,已引起人们越来越多的关注。本文对整体柱的制备方法、结构表征及其应用作一评述。