Empirical likelihood inference for censored median regression model via nonparametric kernel estimation

An alternative to the accelerated failure time model is to regress the median of the failure time on the covariates. In the recent years, censored median regression models have been shown to be useful for analyzing a variety of censored survival data with the robustness property. Based on missing information principle, a semiparametric inference procedure for regression parameter has been developed when censoring variable depends on continuous covariate. In order to improve the low coverage accuracy of such procedure, we apply an empirical likelihood ratio method (EL) to the model and derive the limiting distributions of the estimated and adjusted empirical likelihood ratios for the vector of regression parameter. Two kinds of EL confidence regions for the unknown vector of regression parameters are obtained accordingly. We conduct an extensive simulation study to compare the performance of the proposed methods with that normal approximation based method. The simulation results suggest that the EL methods outperform the normal approximation based method in terms of coverage probability. Finally, we make some discussions about our methods.     

Empirical likelihood inference for median regression models for censored survival data

Recent advances in median regression model have made it possible to use this model for analyzing a variety of censored survival data. For inference on the model parameter vector, there are now semiparametric procedures based on normal approximation that are valid without strong conditions on the error distribution. However, the accuracy of such procedures can be quite low when the censoring proportion is high. In this paper, we propose an alternative semiparametric procedure based on the empirical likelihood. We define the empirical likelihood ratio for the parameter vector and show that its limiting distribution is a weighted sum of chi-square distributions. Numerical results from a simulation study suggest that the empirical likelihood method is more accurate than the normal approximation based method of Ying et al. (J. Amer. Statist. Assoc. 90 (1995) 178).     

Semiparametric inference for transformation models via empirical likelihood

Recent advances in the transformation model have made it possible to use this model for analyzing a variety of censored survival data. For inference on the regression parameters, there are semiparametric procedures based on the normal approximation. However, the accuracy of such procedures can be quite low when the censoring rate is heavy. In this paper, we apply an empirical likelihood ratio method and derive its limiting distribution via U-statistics. We obtain confidence regions for the regression parameters and compare the proposed method with the normal approximation based method in terms of coverage probability. The simulation results demonstrate that the proposed empirical likelihood method overcomes the under-coverage problem substantially and outperforms the normal approximation based method. The proposed method is illustrated with a real data example. Finally, our method can be applied to general U-statistic type estimating equations.     

Empirical likelihood inference for the accelerated failure time model

Accelerated failure time (AFT) models are useful regression tools for studying the association between a survival time and covariates. Semiparametric inference procedures have been proposed in an extensive literature. Among these, use of an estimating equation which is monotone in the regression parameter and has some excellent properties was proposed by Fygenson and Ritov (1994). However, there is a serious under-coverage problem for small sample sizes. In this paper, we derive the limiting distribution of the empirical log-likelihood ratio for the regression parameter on the basis of the monotone estimating equations. Furthermore, the empirical likelihood (EL) confidence intervals/regions for the regression parameter are obtained. We conduct a simulation study in order to compare the proposed EL method with the normal approximation method. The simulation results suggest that the empirical likelihood based method outperforms the normal approximation based method in terms of coverage probability. Thus, the proposed EL method overcomes the under-coverage problem of the normal approximation method.     

Empirical likelihood-based inferences for the area under the ROC curve with covariates

In the receiver operating characteristic (ROC) analysis,the area under the ROC curve (AUC) is a popular summary index of discriminatory accuracy of a diagnostic test.Incorporating covariates into ROC analysis can improve the diagnostic accuracy of the test.Regression model for the AUC is a tool to evaluate the effects of the covariates on the diagnostic accuracy.In this paper,empirical likelihood (EL) method is proposed for the AUC regression model.For the regression parameter vector,it can be shown that the asymptotic distribution of its EL ratio statistic is a weighted sum of independent chi-square distributions.Confidence regions are constructed for the parameter vector based on the newly developed empirical likelihood theorem,as well as for the covariate-specific AUC.Simulation studies were conducted to compare the relative performance of the proposed EL-based methods with the existing method in AUC regression.Finally,the proposed methods are illustrated with a real data set.     

Empirical likelihood for the contrast of two hazard functions with right censoring

In this paper, we consider the standard two-sample framework with right censoring. We construct useful confidence intervals for the ratio or difference of two hazard functions using smoothed empirical likelihood (EL) methods. The empirical log-likelihood ratio is derived and its asymptotic distribution is a standard chi-squared distribution. Bootstrap confidence bands are also proposed. Simulation studies show that the proposed EL confidence intervals have outperformed normal approximation methods in terms of coverage probability. It is concluded that the empirical likelihood methods provide better inference results.     

Empirical likelihood for median regression model with designed censoring variables

We propose a new and simple estimating equation for the parameters in median regression models with designed censoring variables, and then apply the empirical log likelihood ratio statistic to construct confidence region for the parameters. The empirical log likelihood ratio statistic is shown to have a standard chi-square distribution, which makes this method easy to implement. At the same time, another empirical log likelihood ratio statistic is proposed based on an existing estimating equation and the limiting distribution of the empirical likelihood ratio statistic is shown to be a sum of weighted chi-square distributions. We compare the performance of the empirical likelihood confidence region based on the new estimating equation, with that based on the existing estimating equation and a normal approximation method by simulation studies.     

部分函数线性模型的经验似然推断

本文考虑部分函数线性回归模型,研究了回归系数的经验似然推断,证明了所提出的经验对数似然比渐近于χ~2分布,此结果可以用来构造了相应兴趣参数的置信域.另外,本文也给出了系数函数的极大经验似然估计,并在适当条件下给出了所提出估计量的收敛速度.仅就置信域精度及其覆盖概率大小方面,通过模拟研究和实例分析比较了经验似然方法与最小二乘方法的优劣.     

缺失数据下半参数回归模型的经验似然推断

针对响应变量缺失下的半参数回归模型,构造模型中未知参数的经验对数似然比统计量,证明了所提出的统计量具有渐近χ2分布,由此构造未知参数的置信域,并就置信域的覆盖概率及区间长度方面,通过模拟研究与最小二乘法进行优劣比较.     

Empirical likelihood semiparametric nonlinear regression analysis for longitudinal data with responses missing at random

This paper develops the empirical likelihood (EL) inference on parameters and baseline function in a semiparametric nonlinear regression model for longitudinal data in the presence of missing response variables. We propose two EL-based ratio statistics for regression coefficients by introducing the working covariance matrix and a residual-adjusted EL ratio statistic for baseline function. We establish asymptotic properties of the EL estimators for regression coefficients and baseline function. Simulation studies are used to investigate the finite sample performance of our proposed EL methodologies. An AIDS clinical trial data set is used to illustrate our proposed methodologies.     

Quantile regression for right-censored and length-biased data

Length-biased data arise in many important fields, including epidemiological cohort studies, cancer screening trials and labor economics. Analysis of such data has attracted much attention in the literature. In this paper we propose a quantile regression approach for analyzing right-censored and length-biased data. We derive an inverse probability weighted estimating equation corresponding to the quantile regression to correct the bias due to length-bias sampling and informative censoring. This method can easily handle informative censoring induced by length-biased sampling. This is an appealing feature of our proposed method since it is generally difficult to obtain unbiased estimates of risk factors in the presence of length-bias and informative censoring. We establish the consistency and asymptotic distribution of the proposed estimator using empirical process techniques. A resampling method is adopted to estimate the variance of the estimator. We conduct simulation studies to evaluate its finite sample performance and use a real data set to illustrate the application of the proposed method.     

非线性EV回归模型中参数的经验似然置信域

本文考虑非线性EV回归模型，构造了未知参数的经验对数似然比统计量．此外，为了克服计算困难，提出了一个基于模拟的经验对数似然比统计量．在适当条件下，证明了所提出的这两种统计量都具有渐近X^2分布，所得结果可以用来构造未知参数的置信域。     

Likelihood ratio inference for mean residual life of length-biased random variable

In lifetime data analysis, naturally recorded observations are length-biased data if the probability to select an item is proportional to its length. Based on i.i.d. observations of the true distribution, empirical likelihood (EL) procedure is proposed for the inference on mean residual life (MRL) of naturally recorded item. The limit distribution of the EL based log-likelihood ratio is proved to be the chi-square distribution. Under right censorship, since the EL based log-likelihood ratio leads to a scaled chi-square distribution and estimating the scale parameter leads to lower coverage of confidence interval, we propose an algorithm to calculate the likelihood ratio (LR) directly. The corresponding log-likelihood ratio converges to the standard chi-square distribution and the corresponding confidence interval has a better coverage. Simulation studies are used to support the theoretical results.     

非线性半参数回归模型中参数的经验似然置信域

该文考虑非线性半参数回归模型,构造了模型中未知参数的经验对数似然比统计量,证明了所提出的统计量具有渐近Χ²分布,由此结果可以用来构造未知参数的置信域.另外,该文也构造了未知参数 的最小二乘估计量,并证明了它的渐近性质.仅就置信域精度及其覆盖概率大小方面,通过模拟研究比较了经验似然方法与最小二乘法的优劣.     

长度偏差右删失数据剩余寿命的分位数回归

本文研究长度偏差数据下剩余寿命分位数模型的估计方法,充分考虑有偏抽样机制对模型估计的影响.如果忽略这种有偏性会导致估计产生严重偏差甚至错误的结果.本文首先针对长度偏差右删失数据的剩余寿命分位数提出了对数形式的线性回归模型,对删失变量与协变量独立和不独立的两种情况利用估计方程给出了模型参数的估计.其次,通过经验过程和弱收敛理论给出了参数估计的相合性和渐近正态性.最后,本文对提出的估计方法进行了数值模拟并用该方法对奥斯卡奖数据进行分析.     

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This paper is focused on testing the parameters of the quantile regression models. For complete observation, it is shown in literature that the test statistics, based on empirical likelihood (EL) method and smoothed empirical likelihood (SEL) method, both converge weakly to the standard Chi-square distribution $\chi_M^2$ under the null hypothesis. For right censored data, the statistics in literature, by the EL method, have a weighted Chi-square limiting distribution, but the weights are unknown. In this paper, we show that the statistics based on the EL method and the SEL method also converge weakly to $\chi_M^2$ under the null hypothesis, so there is no need to estimate any weights. As its estimating function is smoothed, the SEL method can be Bartlett corrected. Numerical results show that the SEL method, via Bartlett correction, outperforms some recent methods.     

Empirical likelihood for single-index models

The empirical likelihood method is especially useful for constructing confidence intervals or regions of the parameter of interest. This method has been extensively applied to linear regression and generalized linear regression models. In this paper, the empirical likelihood method for single-index regression models is studied. An estimated empirical log-likelihood approach to construct the confidence region of the regression parameter is developed. An adjusted empirical log-likelihood ratio is proved to be asymptotically standard chi-square. A simulation study indicates that compared with a normal approximation-based approach, the proposed method described herein works better in terms of coverage probabilities and areas (lengths) of confidence regions (intervals).     

右删失数据下非线性回归模型的经验似然推断

考虑随机右删失数据下非线性回归模型,提出了模型中未知参数的调整的经验对数似然比统计量.在一定的条件下,证明了.所提出的的统计量具有渐近χ~2分布,由此结果构造了兴趣参数的置信域.通过模拟研究,对经典的经验似然、调整的经验似然和非线性最小二乘方法在有限样本下进行了比较,并对氯离子浓度试验数据进行了分析.     

MA$(q)$模型的经验似然推断

In this article we study the empirical likelihood inference for MA（q） model. We propose the moment restrictions, by which we get the empirical likelihood estimator of the model parameter, and we also propose an empirical log-likelihood ratio based on this estimator. Our result shows that the EL estimator is asymptotically normal, and the empirical log-likelihood ratio is proved to be asymptotical standard chi-square distribution.     

双侧截断数据的中位数回归(英文)

在很多实际应用中,个体寿命时间可能被同时左截断与右截断.本文在左右截断变量都能被观察到的假设下,提出了一种半参数推断方法,来分析协变量对于相应寿命时间或其某种变换的中位数的影响,并讨论了所得估计量的渐近性质.此外,本文还提供了一种基于经验似然的回归参数推断方法,并讨论了将这些方法推广到经典双侧截断数据的可能性.一些模拟计算被用于展示这些方法的有效性.