长度偏差右删失数据剩余寿命的分位数回归

本文研究长度偏差数据下剩余寿命分位数模型的估计方法,充分考虑有偏抽样机制对模型估计的影响.如果忽略这种有偏性会导致估计产生严重偏差甚至错误的结果.本文首先针对长度偏差右删失数据的剩余寿命分位数提出了对数形式的线性回归模型,对删失变量与协变量独立和不独立的两种情况利用估计方程给出了模型参数的估计.其次,通过经验过程和弱收敛理论给出了参数估计的相合性和渐近正态性.最后,本文对提出的估计方法进行了数值模拟并用该方法对奥斯卡奖数据进行分析.     

右删失长度偏差数据分位数差的非参数估计

利用长度偏差数据所特有的辅助信息,对带右删失的长度偏差数据的分位数差提出了一种新的非参数估计.该方法提高了估计的有效性,所得的估计量形式简洁,便于计算.同时,本文用经验过程理论建立了该分位数差估计的相合性及渐近正态性,并给出方差估计的重抽样方法.本文还通过数值模拟考察了该估计量在有限样本下的表现,并将其应用到一个关于老年痴呆的实际数据中.     

Quantile regression of right-censored length-biased data using the Buckley–James-type method

Length-biased data are encountered frequently due to prevalent cohort sampling in follow-up studies. Quantile regression provides great flexibility for assessing covariate effects on survival time, and is a useful alternative to Cox’s proportional hazards model and the accelerated failure time (AFT) model for survival analysis. In this paper, we develop a Buckley–James-type estimator for right-censored length-biased data under a quantile regression model. The problem of informative right-censoring of length-biased data induced by prevalent cohort sampling must be handled. Following on from the generalization of the Buckley–James-type estimator under the AFT model proposed by Ning et al. (Biometrics 67:1369–1378, 2011), we propose a Buckley–James-type estimating equation for regression coefficients in the quantile regression model and develop an iterative algorithm to obtain the estimates. The resulting estimator is consistent and asymptotically normal. We evaluate the performance of the proposed estimator on finite samples using extensive simulation studies. Analysis of real data is presented to illustrate our proposed methodology.     

Nonparametric estimation of a conditional distribution from length-biased data

In this paper we consider the problem of estimating a conditional distribution function in a nonparametric way, when the response variable is nonnegative, and the observational procedure is length-biased. We propose a proper adaptation of the estimate to right-censoring provoked by limitation in following-up. Large sample analysis of the introduced estimator is given, including rates of convergence, limiting distribution, and efficiency results. We show that the length-bias model results in less variance in estimation, when compared to methods based on observed truncation times. Practical performance of the proposed estimator is explored through simulations. Application to unemployment data analysis is provided.     

Smoothing estimation of rate function for recurrent event data with informative censoring

This paper proposes kernel estimation of the occurrence rate function for recurrent event data with informative censoring. An informative censoring model is considered with assumptions made on the joint distribution of the recurrent event process and the censoring time without modeling the censoring distribution. Under the validity of the informative censoring model, we also show that an estimator based on the assumption of independent censoring becomes inappropriate and is generally asymptotically biased. To investigate the asymptotic properties of the proposed estimator, the explicit form of its asymptotic mean squared risk and the asymptotic normality are derived. Meanwhile, the empirical consistent smoothing estimator for the variance function of the estimator is suggested. The performance of the estimators are also studied through Monte Carlo simulations. An epidemiological example of intravenous drug user data is used to show the influence of informative censoring in the estimation of the occurrence rate functions for inpatient cares over time.     

Estimation of the extreme value index and extreme quantiles under random censoring

In this paper, we consider the estimation of the extreme value index and extreme quantiles in the presence of random right censoring. The generalization of the peaks over threshold method is discussed and an adaptation of the moment estimator is proposed. The corresponding extreme quantile estimators are also introduced. We make a start with the analysis of the asymptotic properties of the moment estimator and the corresponding extreme quantile estimator. The finite sample behaviour is illustrated with a small simulation study and through practical examples from survival data analysis.      

Semiparametric quantile regression with random censoring

This paper considers estimation and inference in semiparametric quantile regression models when the response variable is subject to random censoring. The paper considers both the cases of independent and dependent censoring and proposes three iterative estimators based on inverse probability weighting, where the weights are estimated from the censoring distribution using the Kaplan–Meier, a fully parametric and the conditional Kaplan–Meier estimators. The paper proposes a computationally simple resampling technique that can be used to approximate the finite sample distribution of the parametric estimator. The paper also considers inference for both the parametric and nonparametric components of the quantile regression model. Monte Carlo simulations show that the proposed estimators and test statistics have good finite sample properties. Finally, the paper contains a real data application, which illustrates the usefulness of the proposed methods.

     

响应变量删失时函数型部分线性分位数回归模型的估计

最近几年,函数型数据分析的理论和应用飞速发展.在许多实际应用里,响应变量往往存在随机右删失的情况.考虑利用函数型部分线性分位数回归模型来刻画函数型和标量预测量与右删失响应变量之间的关系.基于函数型主成分基函数来逼近未知的斜率函数,通过极小化逆概率加权分位数损失函数得到未知系数的估计量.文章的估计方法容易通过加权分位数回归程序实现.在一定的假设条件下,给出了有限维参数估计量的渐近正态性与斜率函数估计量的收敛速度.最后,通过模拟计算与应用实例证明了所提方法的有效性.     

Efficient estimation and variable selection for infinite variance autoregressive models

In this paper, a self-weighted composite quantile regression estimation procedure is developed to estimate unknown parameter in an infinite variance autoregressive (IVAR) model. The proposed estimator is asymptotically normal and more efficient than a single quantile regression estimator. At the same time, the adaptive least absolute shrinkage and selection operator (LASSO) for variable selection are also suggested. We show that the adaptive LASSO based on the self-weighted composite quantile regression enjoys the oracle properties. Simulation studies and a real data example are conducted to examine the performance of the proposed approaches.     

Variable selection in censored quantile regression with high dimensional data

We propose a two-step variable selection procedure for censored quantile regression with high dimensional predictors. To account for censoring data in high dimensional case, we employ effective dimension reduction and the ideas of informative subset idea. Under some regularity conditions, we show that our procedure enjoys the model selection consistency. Simulation study and real data analysis are conducted to evaluate the finite sample performance of the proposed approach.     

A bootstrap approach to model checking for linear models under length-biased data

In this paper, we propose two bootstrap-based model checking tests for a parametric linear model when data are affected by length-bias. These tests are based on the measure of the discrepancy between nonparametric and parametric estimators for the regression function when the data are drawn under a length-biased mechanism. We consider two different discrepancy measures: the supremum and the integral of the quadratic difference between the parametric and nonparametric estimators.     

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We extend the instrumental variable method for the mean regression models to linear quantile regression models with errors-in-variables. The proposed estimator is consistent and asymptotically normally distributed under some fairly general conditions. Moreover, this approach is practical and easy to implement. Simulation studies show that the finite sample performance of the estimator is satisfactory. The method is applied to a real data study of education and wages.     

Weighted composite quantile estimation and variable selection method for censored regression model

This paper considers the weighted composite quantile (WCQ) regression for linear model with random censoring. The adaptive penalized procedure for variable selection in this model is proposed, and the consistency, asymptotic normality and oracle property of the resulting estimators are also derived. The simulation studies and the analysis of an acute myocardial infarction data set are conducted to illustrate the finite sample performance of the proposed method.     

Joint modeling for mixed-effects quantile regression of longitudinal data with detection limits and covariates measured with error,with application to AIDS studies

It is very common in AIDS studies that response variable (e.g., HIV viral load) may be subject to censoring due to detection limits while covariates (e.g., CD4 cell count) may be measured with error. Failure to take censoring in response variable and measurement errors in covariates into account may introduce substantial bias in estimation and thus lead to unreliable inference. Moreover, with non-normal and/or heteroskedastic data, traditional mean regression models are not robust to tail reactions. In this case, one may find it attractive to estimate extreme causal relationship of covariates to a dependent variable, which can be suitably studied in quantile regression framework. In this paper, we consider joint inference of mixed-effects quantile regression model with right-censored responses and errors in covariates. The inverse censoring probability weighted method and the orthogonal regression method are combined to reduce the biases of estimation caused by censored data and measurement errors. Under some regularity conditions, the consistence and asymptotic normality of estimators are derived. Finally, some simulation studies are implemented and a HIV/AIDS clinical data set is analyzed to to illustrate the proposed procedure.     

Quantile regression based on counting process approach under semi-competing risks data

In this paper, we investigate the quantile regression analysis for semi-competing risks data in which a non-terminal event may be dependently censored by a terminal event. The estimation of quantile regression parameters for the non-terminal event is complicated. We cannot make inference on the non-terminal event without extra assumptions. Thus, we handle this problem by assuming that the joint distribution of the terminal event and the non-terminal event follows a parametric copula model with unspecified marginal distributions. We use the stochastic property of the martingale method to estimate the quantile regression parameters under semi-competing risks data. We also prove the large sample properties of the proposed estimator, and introduce a model diagnostic approach to check model adequacy. From simulation results, it shows that the proposed estimator performs well. For illustration, we apply our proposed approach to analyze a real data.     

Fixed Design Nonparametric Regression with Truncated and Censored Data

In this paper we consider a fixed design model in which the observations axe subject to left truncation and right censoring. A generalized product-limit estimator for the conditional distribution at a given covaxiate value is proposed, and an almost sure asymptotic representation of this estimator is established. We also obtain the rate of uniform consistency, weak convergence and a modulus of continuity for this estimator.Applications include trimmed mean and quantile function estimators.     

左截断双删失数据下可加可乘风险率模型的估计

在生存分析中,可加可乘风险率模型常用来研究协变量对初始事件和终止事件之间持续时间的影响效应。在本文中,我们考虑了在初始事件存在部分区间删失,同时终止事件存在左截断右删失的情形下,持续时间的可加可乘风险率模型的估计问题。我们提出了一个两阶段估计过程来估计模型的回归参数。并通过模拟分析验证了估计的大样本性质。最后利用该方法分析了恶性黑色素瘤手术治疗数据。     

Optimal subsampling for large-scale quantile regression

To deal with massive data sets, subsampling is known as an effective method which can significantly reduce computational costs in estimating model parameters. In this article, an efficient subsampling method is developed for large-scale quantile regression via Poisson sampling framework, which can solve the memory constraint problem imposed by big data. Under some mild conditions, large sample properties for the estimator involving the weak and strong consistencies, and asymptotic normality are established. Furthermore, the optimal subsampling probabilities are derived according to the A-optimality criterion. It is shown that the estimator based on the optimal subsampling asymptotically achieves a smaller variance than that by the uniform random subsampling. The proposed method is illustrated and evaluated through numerical analyses on both simulated and real data sets.     

Proportional Mean Residual Life Model with Varying Coefficients for Length-Biased and Right-Censored Data

Length-biased data are encountered in many fields,including economics,engineering and epidemiological cohort studies.There are two main challenges in the analysis of such data:the assumption of independent censoring is violated and the assumed model for the underlying population is no longer satisfied for the observed data.In this paper,a proportional mean residual life varyingcoefficient model for length-biased data is considered and a local pseudo likelihood method is proposed for estimating the coefficient functions in the model.Asymptotic properties are investigated for the proposed estimators.The finite sample performance of the proposed methodology is demonstrated by simulation studies.Finally,the method is applied to a real data set concerning the Academy Awards.     

失混合效应模型的分位回归及变量选择

纵向数据常常用正态混合效应模型进行分析.然而,违背正态性的假定往往会导致无效的推断.与传统的均值回归相比较,分位回归可以给出响应变量条件分布的完整刻画,对于非正态误差分布也可以给稳健的估计结果．本文主要考虑右删失响应下纵向混合效应模型的分位回归估计和变量选择问题．首先,逆删失概率加权方法被用来得到模型的参数估计．其次,结合逆删失概率加权和LASSO惩罚变量选择方法考虑了模型的变量选择问题.蒙特卡洛模拟显示所提方法要比直接删除删失数据的估计方法更具优势．最后,分析了一组艾滋病数据集来展示所提方法的实际应用效果．