无机化学系列课程教学艺术初探

化学教师不仅应该是化学知识的传播者,还应该具有一定的教育理论造诣,一定的科学研究能力和一定的表演艺术才华.通过基础无机化学、无机材料化学、高等无机化学和无机化学实验等课程的教学,让学生在获得无机化学知识的同时,激发他们的学习兴趣,喜爱化学这门学科,并愿意为化学事业献身.为实现这一目的,我们在从事"高等无机化学"、"基础无机化学"、"无机材料化学"、"无机化学实验"、"无机合成化学"等课程教学的同时,进行了无机化学教学艺术的研究.本文将着重介绍我们在新课的导入艺术、讲授艺术、变化艺术和强化艺术等方面所做的工作.     

“四化”教学在无机化学理论课中的应用实践

在无机化学教学中采用通俗化、系统化、形象化和娱乐化的教学方式,使深奥的理论、抽象的概念变得容易理解和接受,使零散、枯燥的知识变得更易掌握。     

增加药学专业无机化学"药味"的思考与探索

无机化学是医学院校药学专业学生必修的专业基础课程。为了提高教学质量,增强学生的学习兴趣与专业素养,在药学专业无机化学教学中应强化与药学之间的紧密联系。文章结合教学实践,总结了增加药学专业无机化学"药味"的思考与探索。     

大学无机化学实验教学中“问题导学”教学法的探索

介绍了"问题导学"教学法在大学无机化学实验教学中的实施要点,并结合硫酸亚铁铵制备实验教学案例,详细探讨了这一教学法在大学无机化学实验课堂教学中的具体实施策略。     

演示视频在无机化学及实验教学中的应用

无机化学中如何合理地把实验教学和理论教学有机结合起来以达到理想的教学效果,是一个值得研究的课题。介绍了如何利用演示视频来诠释身边的化学知识、解释化学概念以及弥补实验教学的不足,从而提高无机化学及实验的教学效果。     

基于知识体系整合的元素无机化学教学改革

元素无机化学是大学化学及相关专业无机化学课程的核心内容。如何教好、学好元素无机化学的知识一直是教学工作者研究的课题。为改变教学现状，提高教学效果，培养学生的逻辑思维和科学创新能力，提出一种整合元素无机化学知识的思路，即：以化合物类型为主线对元素无机化学知识进行系统化整合，并以氧化物部分为例加以说明。     

无机化学教学中“课程思政”教育的探索与实践

结合无机化学特点,分析专业课教学中开展"课程思政"存在的问题,讨论如何挖掘无机化学课程所蕴含的思想政治教育元素,探索思想政治教育融入无机化学课程的实践途径,提出在专业课教学过程中,通过典型案例融入思政元素的具体方法,以实现价值引领、能力培养和知识传授的"三位一体"教育目标,培养德才兼备的高素质人才。     

无机化学系列课程教学艺术初探

化学教师不仅应该是化学知识的传播者,还应该具有一定的教育理论造诣,一定的科学研究能力和一定的表演艺术才华.通过基础无机化学、无机材料化学、高等无机化学和无机化学实验等课程的教学,让学生在获得无机化学知识的同时,激发他们的学习兴趣,喜爱化学这门学科,并愿意为化学事业献身.为实现这一目的,我们在从事“高等无机化学“、“基础无机化学“、“无机材料化学“、“无机化学实验“、“无机合成化学“等课程教学的同时,进行了无机化学教学艺术的研究.本文将着重介绍我们在新课的导入艺术、讲授艺术、变化艺术和强化艺术等方面所做的工作.……     

在药学院的无机化学教学中培养学生的科学思维能力

通过一些具体实例说明如何在药学院的无机化学课程教学中培养学生的科学思维能力,唤醒学生的求知欲,增强学生获取知识的独立性与主动性。     

压缩学时背景下无机化学教学改革

在无机化学教学学时压缩的背景下,综合考虑我国中学化学课程改革及目前无机化学教学所面临的问题,适度调整、拓宽和深化无机化学教学内容,并基于OBE理念,采用"模块化"教学、"分层化"教学及"专题研讨式"教学,培养学生自主学习能力、解决实际问题的能力以及创新能力,形成"知识-能力"一体化的教育理念。     

IPy2BF4-mediated rearrangements of 1,2-difunctionalized compounds and olefins

Acetal derivatives are easily obtained from 1,2-difunctionalized compounds by a new reaction mediated by IPy2BF4 with a mechanism based on a 1,2-migration of aryl or alkyl groups. A new oxidative rearrangement reaction of olefins is also described. Moreover, when this metal-free protocol is applied to cyclic olefins, interesting ring-contraction reactions are observed. The new methodologies described here are a clean and efficient alternative to known strategies that make use of potentially toxic metallic complexes.     

Brefeldin A全合成研究新进展

Brefeldin A(布雷菲德菌素甲)是一种天然抗生素, 最早发现于1958年, 许多种微生物中都能产生该化合物. 由于其有趣的结构和显著的抗真菌、抗病毒、抗肿瘤等生物活性, 该化合物很早就引起合成化学家们的注意. 到目前为止, 文献中有报道的全合成和表观合成已有30多种. 对近十年来的全合成及部分表观合成进行了综述, 对各路线的主要优缺点也进行了简要的分析. 一些类似物的合成也一并予以简介.     

Copper catalysed cross-dehydrogenative coupling (CDC) reaction of 4-thiazolidinone with terminal alkyne

Cross dehydrogenative coupling (CDC) strategy has been employed for C-alkynylation of 4-thiazolidinone with terminal alkyne under copper catalysis. Present reaction involves coupling of C(sp³) adjacent to sulfur of 4-thiazolidinone with C(sp) of terminal alkyne under CDC strategy is unprecedented to the best of our knowledge. Significant functional group tolerance, considerable yield and DFT study for mechanism make this synthetic task more interesting and compatible.     

Combination of DES and macrocyclic host molecules: Review and perspectives

Solvation in deep eutectic solvents (DESs) and encapsulation in macrocycles are efficient strategies for molecule's solubilization. Recently, new systems combining DES and macrocycles are being constructed using two approaches: a) solubilizing hosts in preformed DES or b) using hosts as a DES component. This strategy could evolve in new outcomes in DES properties, more precisely provide the solvents with supramolecular capacity, and translate into interesting performances. In the present review, we will give the reader an overview of the studies accomplished in this growing research area, with a focus on the experimental perspectives that we consider to be the most important in order to enlarge knowledge on the properties and behavior of these neoteric systems.     

Neutron activation analysis of Nigerian crude oils

Since the advent of the Nuclear Age mankind has been both fascinated by the potential of nuclear processes, and fearful of its destructive power. Nuclear technologies have undergone rapid development, while most of society is left with a poor understanding about the benefits and risks involved. Our Nuclear Society: from Chemobyl to PET Scans, and Energy, Technology and Risk are two courses developed at the University of Maryland in an effort to introduce students from all backgrounds to issues and applications of nuclear science. Course material and presentation strategies are geared toward keeping the course interesting and informative for all students.     

What Do We Know about the Deeper Layers of the Earth?

In the last twenty years modern chemical and physical methods have done much to extend our knowledge of the Earth. Some new questions have been raised, e.g. the question of the bonding relationships in the Earth's interior, which make the Earth an interesting object of research to chemists as well. This progress report attempts to give a survey of the Earth's structure as seen at the present day. Naturally, special emphasis has been placed on those aspects which concern the chemist.     

Bottom-up supramolecular assembly in two dimensions

The self-assembly of molecules in two dimensions (2D) is gathering attention from all disciplines across the chemical sciences. Attracted by the interesting properties of two-dimensional inorganic analogues, monomers of different chemical natures are being explored for the assembly of dynamic 2D systems. Although many important discoveries have been already achieved, great challenges are still to be addressed in this field. Hierarchical multicomponent assembly, directional non-covalent growth and internal structural control are a just a few of the examples that will be discussed in this perspective about the exciting present and the bright future of two-dimensional supramolecular assemblies.

The self-assembly of molecules in two dimensions (2D) is gathering attention from all disciplines across the chemical sciences. This perspective discusses the main strategies to direct the supramolecular self-assembly of organic monomers in 2D.     

Hen egg white fractionation by ion-exchange chromatography

Major hen egg white proteins have been widely studied for their functional properties but these studies still are unable to explain, alone, all of the biological properties of hen egg white. Hence, it is still interesting to produce pure and non-altered proteins to improve our knowledge on the biological properties of hen egg white. Presently, identification and characterization of both bioactive peptides and minor proteins from hen egg white is essential work for progressing in the understanding of hen egg white biological properties. With this objective in mind, a new process for a complete "mucin free" hen egg white fractionation based on ion exchange chromatography is proposed. "Mucin free" egg white is fractionated into six different fractions. Four of them are high-recovery yield purified fractions of lysozyme, ovotransferrin, ovalbumin and flavoprotein. The two other fractions are enriched in recently detected minor proteins in hen egg white.     

Ghrelin Detection Using Spiegelmer‐Capture Molecules

Abstract

The aim of this work was to review the development of aptamer‐based assay understanding for possible diagnostic applications. The use of new affinity ligands such as the single strand DNA is particularly suitable for large‐scale synthesis and overcomes the disadvantages of antibodies or enzymes, which are often unstable and expensive. The latest class of potential aptamers is enantiomeric aptamers composed of l‐nucleotides, the so‐called spiegelmers. Attributing to the unnatural sugars used, spiegelmers are resistant to host nucleases, exploring the possibility to work in a complex matrix‐like blood.

After analyzing the strategies reported in the literature for the detection of the aptamer‐target complex formation, we reported our experience in the realization of two bioassays, based on electrochemical or colorimetric detection, using the unusual aptamer for the detection of ghrelin.

This work can open interesting applications in biosensing technology. There are few analytical reports on bioassay using spiegelmers. The new field is extremely interesting, considering that these new analytical tools hold an enormous promise for a fast and simple diagnosis of genetic problems in real matrices.     

化学与社会课程授课方式探讨

重点讲述了北京科技大学“化学与社会”课程课堂讲授方式的改革与实践,并与传统授课模式的效果进行了比较,提出在教学大纲范畴内,以“教无定法”为思想宗旨,使得大学化学课堂的授课方式呈现多样性,并在实践中取得了很好的教学效果.