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Abstract Reaction of 4,5-dibromobicyclo[6.1.0]non-4-ene with anhydrous AlBr3 forms (1R?,2S?,5R?,6R?)-1-methyl-2,5,6-tribromocyclooctane and 3-methyl-6,7-dibromocyclooctene. 相似文献
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Synthesis and Crystal Structure of 5(R)-(1R,2S,5R)-Menthoxy-4(R)- N-cyclohexylaminobutyrolactone 总被引:1,自引:0,他引:1
1INTRODUCTION Substitutedγ-butyrolactones are a group of impor-tant compounds containing unique carbon skeleton of butyrolactone which is widely present in many natural products and have received considerable interest because of their biological and medicinal properties[1~4].Therefore,much attention has been paid to the new asymmetric methods for synthesi-zing these interesting compounds[5~11].The prece-ding results led us to explore the possibility of using cyclohexylamine to convert5(… 相似文献
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1INTRODUCTIONIntheearly1970'sthreegroupsofinvestigatorsL,~,'foundthatlow-valenttita-nium,preparedbythereactionofstrongreducingagentswithtitaniumtrichlorideortitaniumtetrachlorideintetrahydrofuran,canabstractoxygenfromketonesoraldehydes,leadingtotheforma-tionofolefins.Theinterestinthereactioninducedbylow--valenttitaniumreagentsisincreasingandalargenumberoffunctionalgroupscanbereduceds4-6).Recent-ly,wefoundthatthetitlecompoundisObtainedbycy-cllzatlonreactionof(3--oxo-1,3-diphenyl)propyl-pro… 相似文献
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The clusters Fe3(CO)9(RC2
R
1) (R=R
1=Ph, Et; R=Me, R
1=Ph), complexes 1a, 1b, 1c, containing an alkyne bound in perpendicular fashion with respect to a cluster edge, catalyze the hydrogenation of some acetylenes either under homogeneous and solid–gas conditions. We hypothesize that cluster catalysis occurs and that the catalytic activity is related to the coordinating ability of the alkynic substrates. Competition between hydrogenation and formation of metallacyclic byproducts occurs. The new metallacyclic derivatives Fe3(CO)6(-CO)2{(RC2
R
1)(R
2C2
R
3)}, Fe2(CO)6{(RC2
R
1)(R
2C2
R
3)} {R=R
1=Et, R
2=R
3=H, Ph; R
2=Me, R
3=Et, Ph; R
2=H, R
3=Bu
t
. R=R
1=Ph, R
2=Me, R
3=Et, Ph} (complexes 2, 3) were found both in the homogeneous reaction mixtures and after the solid–gas reactions. The formation of these products lowers the catalytic activity. 相似文献
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《Comptes Rendus Chimie》2003,6(2):189-191
Chiral ammonium cations of the type [R1R2R3R4N]+, new templates for a new family of bimetallic oxalate bridged networks. This work deals with the obtention of a new family of bimetallic [R1R2R3R4N][MnCr(C2O4)3] oxalate bridged 2D networks templated by chiral ammonium cations of the type [R1R2R3R4N]+, in which R stands for n-alkyl groups from methyl to dodecyl. To cite this article: M. Gruselle et al., C. R. Chimie 6 (2003). 相似文献
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《Tetrahedron: Asymmetry》1999,10(12):2337-2342
1α,24(R)-Dihydroxycholesterol, which is the key intermediate for the synthesis of 1α,24(R)-dihydroxyvitamin D3, was effectively synthesized via stereoselective esterification of the 24(R)-hydroxy group using a lipase in combination with inversion of configuration of the 24(S)-hydroxy group using the Mitsunobu reaction (R:S=99:1). 相似文献
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本文采用基于R基团搜索技术的Topomer CoMFA方法对41个人类免疫缺陷病毒(HIV-1)逆转录酶抑制剂进行了三维定量构效关系(3D-QSAR)分析。所得优化模型的拟合、交互验证及外部验证的复相关系数分别为0.995、0.859和0.945。采用Topomer Search技术对ZINC数据库进行R基团的虚拟筛选,得到R贡献高的基团,以活性最高的13号分子为模板进行过滤得到1个Ra基团和20个Rb基团。并以此设计得到20个新化合物分子,其中有19个化合物的预测活性值高于13号分子。研究结果表明,所建立的Topomer CoMFA模型具有良好的稳定性和预测能力,基于R基团的Topomer Search技术可以有效筛选并设计出新的HIV-1逆转录酶抑制剂,为抗艾滋病新药设计提供了理论依据。 相似文献
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H. Zettler 《Fresenius' Journal of Analytical Chemistry》1954,142(4):282-283
Ohne Zusammenfassung 相似文献
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H. Zettler 《Analytical and bioanalytical chemistry》1954,143(4):282-283
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