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5,6-Dihydro-OSW-1 (1) was synthesized following our previous procedure for the total synthesis of OSW-1. This compound demonstrated slightly stronger potency than that of OSW-1 against the growth of cancer cells. 相似文献
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细胞内超过50%的蛋白质为糖蛋白,糖基在很大程度上影响着蛋白质的折叠、稳定性、信号传导、生物活性、免疫原性及药代动力学等.化学糖基化是获得糖基结构和糖基化位置确定的糖蛋白的有效方法.本文以糖蛋白合成技术的发展和应用为导向,围绕糖-肽键的形成,概述了蛋白的化学糖基化研究进展. 相似文献
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Propyl O-(α-L-rhamncpyranosyl)-(1→3)-[2,4-di-O-(2s-methylbutyryl)-α-L-rham-nopyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside (1), the tetrasac-charide moiety of Tricolorin A, was synthesized in total 23 steps with a longest linear sequence of 10 steps, and overall yield of 3.7% from D-Glucose. The isomerization of the dioxolane-type berzyli-dene in the presence of NIS/AgOTf was observed. Tetrasaccharide 1 exhibited no activity against the cultured P388 cell as Tricolorin A did. 相似文献
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A new method for the preparation of 1,6-anhydrohexopyranoses was developed,which mainly involved a "one pot" condensation of 1,6-hydroxyls of the corresponding hexopyranoses under N,N'-sulfuryldiimidazole and sodium hydride. 相似文献
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The protected apiose-containing disaccharide, benzyl O-(2,3, 3'-tri-O-acetyl-β-D-apiofuranosyl)-( 1→3)-2, 4-di-O-benzoyl-α-D-xylopyranoside, was synthesized and its X-ray structure provided. 相似文献
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发展了一条合成苯丙素苷类化合物的通用路线,并依据此路线完成了苯丙素苷毛蕊花糖苷(Acteoside)和异毛蕊花糖苷(Isoacteoside)的全合成及紫茎女贞苷J(Ligupurpuroside J)的首次全合成.其中的关键步骤是应用金(Ⅰ)催化的鼠李糖邻炔基苯甲酸酯给体与多羟基裸露的2-苯乙基葡萄糖苷进行区域选择性糖苷化反应,成功构建天然苯丙素苷中常见的α-(1→3)糖苷键.该合成路线减少了保护基的使用,简洁高效. 相似文献