[Ru6（CO）18]^2—在NaX分子筛超笼中的合成和表征

安脑定痛冲剂系小柴胡汤为基础方加川芎、白芷等组成。具有疏肝调气，行气活血，通络定痛的作用。临床治疗血管性头痛１００例，结果治愈４３例，显效３３例，有效１８例，无效６，总有效率９４％。从中医证候分型来看，本品对气滞血瘀形疗效最好，其次是痰浊血瘀型，对阴虚阳亢型疗效较差。     

针灸治疗面瘫临床疗效观察

目的分析研究针灸治疗面瘫的临床效果。方法将40例面瘫患者随机分成对照组和实验组各20例,对照组患者采用常规西医疗法治疗,实验组患者采用中医针灸方法治疗,两组均治疗3个疗程后统计疗效。结果治疗组总有效率为95%,对照组总有效率为80%,治疗组疗效优于对照组,具有非常显著性差异(P0.05)。结论在治疗过程中,较常规针刺疗法,针灸疗法使面神经恢复正常功能;治疗时病人痛苦小,疗程短,疗效显著,为治疗面瘫首选方法。     

中药当归芍药散治疗慢性肝炎的临床研究

目的 探讨中药当归芍药散治疗慢性乙型肝炎的临床疗效及作用机制。方法 用中药当归芍药散以疏肝健脾,活血化瘀,健脾利湿为法治疗慢性乙型肝炎肝郁脾虚证患者30例,并以健脾益肝汤为对照组进行比较。结果 治疗组显效率为43.33%,有效率为43.33%,总有效率为86.67%,对照组显效率为30.00%,有效率为46.67%,总有效率为76.67%,经统计学处理,两组显效率及总有效率均差异有显著性(P0.05),说明治疗组疗效优于对照组。此外,治疗组在减轻症状、体征,改善肝功能、肝脾B型超声等方面均明显优于对照组。结论 中药当归芍药散是《金匮要略论注》经验方,经临床观察及实验研究,有明显的疏肝健脾,活血化瘀,健脾利湿功效,临床用以治疗慢性乙型肝炎肝郁脾虚证收到很好的疗效。中药当归芍药散具有明显的保肝降酶、改善临床症状、体征的作用,临床观察疗效确切,无毒副作用,治疗慢性乙型肝炎极具研究价值及开发前景。     

氯氮平治疗难治性精神分裂症的效果探讨

目的探讨氯氮平治疗难治性精神分裂症的效果。方法选取88例难治性精神分裂症患者,随机分为实验组与对照组,每组44例,给予对照组利培酮治疗,给予实验组在利培酮治疗基础上使用氯氮平治疗,观察两组患者的治疗效果。结果实验组患者治疗总有效率为93.2%,对照组患者总有效率为79.5%;治疗后实验组患者的PANSS评分明显低于对照组,对比差异显著(P0.05),具有统计学意义。结论针对难治性精神分裂症患者,使用氯氮平治疗,可以有效地提高治疗效果,减轻患者的临床症状,提高生活质量,值得推广使用。     

急诊内科治疗老年重症心力衰竭的临床疗效观察

目的探析老年重症心力衰竭在急诊内科治疗的临床效果。方法选取佛山市第一人民医院2014年1月—2015年6月收治的98例老年重症心力衰竭患者,将其随机分为治疗组和对照组,各为49例,对照组给予利尿剂、强心剂等常规治疗,治疗组在对照组的基础上给予厄贝尔沙坦氢氯噻嗪与美托洛尔联合治疗,对比分析两组患者的治疗疗效及临床指标改善情况。结果治疗组33例显效,15例有效,1例无效,总有效率为97.96%,对照组20例显效,16例有效,13例无效,总有效率为73.47%,两组比较差异显著,P0.05;治疗前两组患者的临床指标差异不显著,P0.05,治疗后,治疗组在LVFE(左室射血分数)、NYHA(心功能分级)及BNP(B型利钠肽)上较对照组比较差异显著,P0.05。结论老年重症心力衰竭在急诊内科治疗中加以厄贝尔沙坦氢氯噻嗪与美托洛尔,临床疗效更加显著,患者的临床指标改善更明显,值得应用。     

固定义齿与活动义齿用于牙周病修复治疗临床疗效

目的总结对比固定义齿与活动义齿用于牙周病修复治疗的临床疗效和差异。方法选择2008年1月—2013年12月期间佛山市顺德区第一人民医院收治的55例牙周病患者,随机分为实验组和对照组。对照组25例采用固定义齿修复治疗,实验组30例采用活动义齿修复治疗。观察记录两组患者的基牙出血指数以及患者治疗满意度。结果实验组治疗后的出血指数(1.02±0.39)明显低于对照组治疗后的出血指数(1.51±0.63),差异具有统计学意义(P0.05);实验组的治疗满意度93.33%明显高于对照组治疗满意度72.00%,差异具有统计学意义(P0.05)。结论采用活动义齿修复治疗牙周病的临床疗效好,患者满意度高,值得临床推广应用。     

综合疗法治疗慢性盆腔炎60例临床观察

目的观察综合治疗慢性盆腔炎的疗效,方法 60例患者均采用中医中药、物理疗法配合抗生素治疗,1个月为1疗程,连续治疗3个疗程。结果治愈37例,显效13例,有效8例,无效2例,总有效率为96.66%。结论综合治疗法治疗慢性盆腔炎疗效显著。     

可吸收螺钉内固定治疗骨折的疗效及临床优势分析

目的分析可吸收螺钉内固定治疗内踝关节骨折的疗效及临床优势。方法研究对象选取2012年6月至2014年5月86例内踝关节骨折患者,根据随机原则分成对照组和实验组。其中对照组患者采用金属螺钉内固定治疗,实验组患者采用可吸收螺钉内固定治疗。术后随访1年,对比两组患者踝关节功能恢复情况的差异。结果经过数据统计发现,对照组患者术后1年时踝关节功能为优22例、良15例、可4例、差2例,优良率为86.05%;实验组患者术后1年时踝关节功能为优26例、良16例、可1例,优良率为97.67%。实验组患者术后踝关节功能优良率明显高于对照组,组间有显著的统计学差异(P0.05)。结论可吸收螺钉内固定治疗骨折的疗效确切,且避免了二次手术的创伤,可将其作为内踝关节骨折治疗的有效方案推广应用。     

高压氧治疗糖尿病足的疗效分析

为观察高压氧(HBO)治疗糖尿病并发糖尿病足的临床疗效,HBO组36例患者在使用抗生素及局部换药等治疗的同时,采用HBO治疗;对照组34例患者仅使用抗生素及局部换药等治疗。结果表明,HBO组患者总的有效率为91.7%,而对照组总有效率为67.5%,两组的疗效有显著性差异(P<0.05)。HBO对糖尿病足有显著的疗效,值得临床进一步研究和应用。     

非ST段抬高急性冠脉综合征68例危险分层和药物治疗

为探讨非ST段抬高型急性冠状动脉综合征(ACS)的危险分层和药物治疗方法,回顾分析了68例非ST段抬高ACS患者的临床资料。根据患者的危险因素分为低危组和高危组,两组均予阿司匹林、β受体阻滞剂、硝酸甘油、他汀类药等,高危组加用低分子肝素钙治疗一周,观察了治疗后胸痛和心电图的变化。结果表明,全组68例患者中[低危组32例(47.1%),高危组36例(52.9%)],低危组临床疗效总有效率93.7%,高危组总有效率88.9%,两组比较,P>0.05。提示根据危险分层合理选择用药是对非ST段抬高ACS药物治疗的有效方法。     

利用手持技术改进测定乙醇分子结构实验

利用压强传感器代替排水集气法,改进测定乙醇分子结构实验的仪器装置,并探索最佳反应条件。另外,设计两个空白实验,结合压强变化曲线对实验误差进行相关讨论。     

Neutral diterpenoids of oleoresins of five species of conifers of Transcarpathia

The compositions of the neutral diterpenoids of the oleoresins of five species of conifers growing in the Transcarpathia have been studied. It has been found that the oleoresins ofAbies alba M.,Larix decidua M., andPicea excelsa L. contain more than 50% of neutral diterpenoids. The group and qualitative compositions of the oxygen-containing diterpenoids have been determined. In the oleoresins ofAbies alba,Picea excelsa, andPicea abies tertiary alcohols — cis-abienol and isocembrol — predominate, while inLarix decidua the main component is the hydroxy ester larixyl acetate. Primary alcohols related to the resin acids have been found in all the oleoresins investigated. Features of the distribution of diterpenoids according to the species of conifers have been revealed. The results obtained are necessary for the chemotaxonomy of conifers of the family Pinceae.Novosibirsk Institute of Organic Chemistry, Siberian Branch, Academy of Sciences of the USSR. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 812–816, November–December, 1988.     

光谱仪测试范围的扩展

由于石化行业的生产需要，其材质的使用具有多样性和广泛性，经常会出现顾客委托的测试样品的一个或几个元素跨越光谱仪现有测试程序测量范围的情况。本法通过对光谱仪测试原理的认识，根据光谱仪的测试能力及标样的采集，实现了一个或几个元素测量范围的扩展，并对其测量的影响因素进行了研究。     

Influence of viscosity of medium on processes of oxygen quenching of excited states of mesoporphyrin

The oxygen quenching rate constants for singlet and triplet excited states of the dimethyl ester of mesoporphyrin IX increase with decreasing viscosity of the medium and reach a maximum at a viscosity of approximately 0.4 mPa·sec, after which the rate constants begin to decrease. The drop in rate constant with increasing fluidity of the medium may be related to a nonequilibrium character of the elementary act in the interaction of the reactants in the solvent cage. In viscous media such as isopropyl alcohol, isobutyl alcohol, and isoamyl alcohol, the reaction radius is greater than the sum of the radii of the reacting particles. The long-range character of these processes is due to the relatively weak dependence of the quenching probability on distance.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 25, No. 2, pp. 161–167, March–April, 1989.     

Dichroism of absorption and polarization of phosphorescence of molecules of the closed form of nitrobenzospirothiopyran

The spectral-polarization characteristics of absorption and phosphorescence of molecules of the initial form of nitro-substituted indolinospirobenzothiopyran were studied in oriented polyethylene films and in solutions with different polarity. An oscillator model of the electron transitions responsible for the formation of absorption and luminescence spectra was suggested. It was established that the principal differences in the spectral and photophysical properties of the compound studied and its oxygen-containing analog are associated with the fact that the electronegativity of the S atom is lower than that of the O atom. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1143–1146, June, 1997.     

Determination of heats of detonation and influence of components of composite explosives on heats of detonation of high explosives

The heats of detonation of 20 simple high explosives and explosive mixtures were determined by means of an adiabatic detonation calorimeter designed by the authors. The results indicated that the performance of the instrument was reliable and the experimental data were very accurate. For explosive mixtures, there was a linear accumulative relationship between the heats of detonation of the explosive mixture and its components. Accordingly, the heats of detonation of explosive mixtures could be calculated directly from the heats of detonation of simple explosives and the characteristic heats of other components. The experiments showed that the gold or brass shell of the cylindrical charge could be substituted by a thick-walled porcelain shell, which had the advantage of cheapness.

     

物质分配系数的测定实验改进

实验教学目的是从解决实际问题出发,以实验技术训练和实验设计思想培养为目标。介绍了将单一的物质分配系数测定实验改进为综合实验,提高了实验效果及实验资源利用率。     

Calculation of enthalpies of hydrogenation of hydrocarbons

Sets of hydrogen molecule equivalents have been developed which permit the calculation of hydrogenation of different types of carbon-carbon bonds from ab initio total energies (3-21G and 6-31G* basis sets, and, to a more limited extent, for MP2/6-31G* data) of reactants and products. The calculated enthalpies of hydrogenation are in good agreement with experiment for unstrained molecules, with average errors on the order of 2 kcal/mol. The 6-31G* equivalents allow the enthalpies for strained molecules to be calculated accurately, but the 3-21G equivalents do not. The equivalents for both basis sets have been tested by calculating the enthalpies of hydrogenation of carbon-carbon bonds in nitrogen- and oxygen-containing organic molecules, free radicals, and classical carbocations. The results are in good agreement with experiment in most cases.     

非那雄胺合成工艺改进

非那雄胺能抑制5α-还原酶的活性,明显降低二氢睾酮水平,是一种治疗良性前列腺增生的有效药品。该合成工艺以甾烯酮酸为原料,将其与氯化亚砜反应,无须分离即与叔丁胺反应得17β-酰胺化合物,再氧化开环,环合,氢化,脱氢合成了非那雄胺。经元素分析、IR、1HNMR、13CNMR、MS分析表征了其结构。该法无须使用昂贵的2,2-二吡啶二硫化物和剧毒药品苯亚硒酸酐,且以乙酸铵代替氨气,降低了对设备的要求和腐蚀,更适用于工业生产。