共查询到20条相似文献,搜索用时 184 毫秒
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以取代苄氧基吲哚-3-甲醛和4-硝基苯肼为原料,乙醇为溶剂,通过缩合脱水反应合成了4个新化合物--取代苄氧基吲哚-3-甲醛-(4'-硝基)苯腙,其结构经1H NMR,IR,MS和元素分析表征. 相似文献
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以取代苄氧基吲哚-3-甲醛和4-硝基苯肼为原料,乙醇为溶剂,通过缩合脱水反应合成了4个新化合物——取代苄氧基吲哚-3-甲醛-(4′-硝基)苯腙,其结构经1H NMR,IR,MS和元素分析表征。 相似文献
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El-Emam AA Alrashood KA Al-Omar MA Al-Tamimi AM 《Molecules (Basel, Switzerland)》2012,17(3):3475-3483
The reaction of adamantane-1-carbohydrazide (1) with heterocyclic aldehydes, namely 5-(4-chlorophenyl)isoxazole-3-carboxaldehyde (2a), 5-(4-methylphenyl)isoxazole-3-carboxaldehyde (2b), 5-(4-methoxyphenyl)isoxazole-3-carboxaldehyde (2c), 1H-imidazole-2-carboxaldehyde and 2-butyl-4-chloro-1H-imidazole-5-carboxaldehyde, in ethanol, yielded the corresponding N'-heteroarylidene-1-adamantylcarbohydrazides 3a, 3b, 3c, 4 and 5, respectively, in good yields. The 4-acetyl-1,3,4-oxadiazoline analogues 6a?c were prepared in 48-55% yields by heating their corresponding N'-heteroarylidene-1-adamantylcarbohydrazides 3a-c with acetic anhydride for two hours. Compounds 3a-c, 4, 5 and 6a-c were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Compounds 4 and 5 displayed potent broad-spectrum antimicrobial activity, while compounds 3a-c showed good activity against the Gram-positive bacteria. 相似文献
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An efficient synthesis of 9H-xanthene-9-carboxaldehyde (3a), 9H-thioxanthene-9-carboxaldehyde (3b), and 9,10-dihydro-10-methyl-9-acridinecarboxaldehyde (3c) by a novel two-carbon homologation of xanthydrol (1a), thioxanthydrol (1b), and 9,10-dihydro-10-methyl-9-acridinol (1c), respectively, using N-vinylacetamides (2a,b) or ethyl vinyl ether (2c) as acetaldehyde anion equivalents, is described. 相似文献
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Wittig condensations of both stabilized and unstabilized ylides were successfully achieved with 2-acetamido-4-hydroxy-5-phenylbutylpyrimidine-6-carboxaldehyde (XI); functionalized Wittig reagents derived from dichloroacetone, ethyl 4-iodobutyrate, 4-bromobutyronitrile, phenylpropyl bromide, 3-bromopropylphthalimide, p - nitrobenzyl bromide, and p-nitrocinnamyl bromide were used. The resultant 6-substituted pyrimidines could be further transformed by reduction of the 6-side-chain double bond. Successful Wittig reactions were achieved with XI where the corresponding 2-amino-4-hydroxy-5-phenylbutylpyrimidine-6-carboxaldehyde (X) with its less electrophilic aldehyde group failed to give isolable yields of condensation products. 相似文献
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《Journal of Coordination Chemistry》2012,65(11):1914-1930
The zinc(II), copper(II), nickel(II), and cobalt(II) complexes of Schiff bases, obtained by the condensation of cefixime with furyl-2-carboxaldehyde, thiophene-2-carboxaldehyde, salicylaldehyde, pyrrol-2-carboxaldehyde, and 3-hydroxynaphthalene-2-carboxaldehyde, were synthesized and characterized by their elemental analyses, molar conductances, magnetic moments, IR, and electronic spectral measurements. Analytical data and electrical conductivity measurements indicated the formation of M?:?L (1?:?2) complexes, [M(L)2(H2O)2] or [M(L)2(H2O)2]Cl2 [where M?=?Zn(II), Cu(II), Ni(II), and Co(II)] in which ligands are bidentate via azomethine-N and deprotonated-O of salicyl and naphthyl, furanyl-O, thienyl-S, and deprotonated pyrrolyl-N. The magnetic moments and electronic spectral data suggest octahedral complexes. The synthesized ligands, along with their metal complexes, were screened for their antibacterial activity against different bacterial strains. The studies show the metal complexes to be more active against one or more species as compared to the uncomplexed ligands. 相似文献
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Vera L. M. Silva Artur M. S. Silva Diana C. G. A. Pinto José A. S. Cavaleiro Attila Vasas Tamás Patonay 《Monatshefte für Chemie / Chemical Monthly》2008,5(1):1307-1315
Several (E)- and (Z)-3-styrylchromones were prepared by two different methodologies, the Wittig reaction of chromone-3-carboxaldehyde with benzylic ylides and the Knoevenagel condensation of chromone-3-carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under microwave irradiation. The Knoevenagel reaction followed by a decarboxylation offered an efficient and diastereoselective method for preparing (E)-3-styrylchromones in a shorter reaction time. It was also demonstrated that phenylacetic acid can also be substituted with
success by phenylmalonic acid. The stereochemistry of all products was assigned by NMR experiments. 相似文献
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Nehad A. Abd El-Latif Abd El-Galil E. Amr Alhusain A. Ibrahiem 《Monatshefte für Chemie / Chemical Monthly》2007,138(6):559-567
Summary. A series of substituted pyridine derivatives were prepared from 3-acetylpyridine, which was prepared from the corresponding
nicotinic acid as a natural starting material. Reaction of 3-acetylpyridine with indole-3-carboxaldehyde afforded the corresponding
3-β-(3-indolyl)acryloylpyridine, which was reacted with hydroxylamine hydrochloride in pyridine or acetic acid in the presence
of sodium acetate to afford 3-β-(3-indolyl)acryloylpyridine oxime and oxazole derivatives. The oxime was treated with ethyl
isothiocyanate or toluene-3,5-diisocyanate in refluxing dioxane to give the corresponding ethyl thiosemicarbazide and 3,5-bissemicarbazide
derivative. 3-β-(3-Indolyl)acryloylpyridine was condensed with malononitrile in refluxing ethanol in the presence of piperidine
as a catalyst to give cyanoaminopyrane, while it was condensed with ethyl cyanoacetate or malononitrile in the presence of
ammonium acetate to yield cyanopyridone and cyanoaminopyridine derivatives. Cyclization of acryloylpyridine with o-phenylenediamine in refluxing butanol led to the formation of the corresponding benzodiazipine via the intermediate A. Finally, cycloaddition reaction of acryloylpyridine with thiourea yielded thioxopyrimidine, which was treated with chloroacetic
acid to yield thiazolopyrimidine. An arylmethylene derivative was prepared by reacting thiazolopyrimidine with indole-3-carboxaldehyde
or by reacting thioxopyrimidine with indole-3-carboxaldehyde and chloroacetic acid in one step. The pharmacological screening
showed that many of these obtained compounds have good analgesic and anticonvulsant activities comparable to Valdecoxib? and Carbamazepine? as reference drugs. 相似文献
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Jianming Cheng Padmanabhan Sekher Sukhwindar P. Singh James E. Gano Alan R. Morgan 《合成通讯》2013,43(4):673-680
1,2-Bis(2-pyrryl)ethenes were synthesized in high yields by the low-valent titanium mediated reductive coupling of pyrrole-2-carboxaldehydes. The reactions of pyrrole-2-carboxaldehyde under lowvalent titanium conditions were different from those of pyrrole-3-carbonyl compounds. 相似文献
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Vera L. M. Silva Artur M. S. Silva Diana C. G. A. Pinto José A. S. Cavaleiro Attila Vasas Tamás Patonay 《Monatshefte für Chemie / Chemical Monthly》2008,139(11):1307-1315
Several (E)- and (Z)-3-styrylchromones were prepared by two different methodologies, the Wittig reaction of chromone-3-carboxaldehyde with benzylic ylides and the Knoevenagel condensation of chromone-3-carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under microwave irradiation. The Knoevenagel reaction followed by a decarboxylation offered an efficient and diastereoselective method for preparing (E)-3-styrylchromones in a shorter reaction time. It was also demonstrated that phenylacetic acid can also be substituted with
success by phenylmalonic acid. The stereochemistry of all products was assigned by NMR experiments.
Correspondence: Artur M. S. Silva, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal. 相似文献